Mechri, Sondes published the artcileAnti-Biofilm, Antioxidant and Cytotoxic Potential of F5, a Peptide Derived from Waste Generated During the Processing of the White Shrimp, Metapenaeus monoceros (Fabricius, 1798), Computed Properties of 30931-67-0, the publication is Waste and Biomass Valorization (2022), 13(7), 3233-3244, database is CAplus.
In previous research works, we have described the production of 7 kDa F5 peptide after a hydrolysis of the white shrimp, Metapenaeus monoceros (Fabricius, 1798) byproduct, using a serine alk. protease (SPVP) purified from Aeribacillus pallidus strain VP3. The present study aims to explore the antioxidative potentials of F5 peptide by both in vitro and in vivo assays. The anti-biofilm activity was performed, showing 50% inhibition at 2μg/mL, 3μg/mL, 19μg/mL, and 45μg/mL for Staphylococcus aureus, Escherichia coli, Bacillus cereus, and Pseudomonas aeruginosa, resp. Consistently, the antioxidative capacity was tested in vitro against 2,2′-azino-bis-(3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS) cation radical, β-caroten-linoleic acid bleaching, chelating capacity of ferrous ion, and ferric reducing power assays. The cytotoxic effects of F5 peptide on the Human embryonic kidney HEK293 cells were subsequently tested. Remarkably, the F5 peptide was able to improve significantly HEK293 cell viability. To further assess this bioactivity, an in vivo study was performed on adult mice models. The animals were divided into three groups: controls, 100 mg and 200 mg of F5/kg per bodyweight. Indeed, the F5 peptide could prevent the lipid and protein oxidation damage in kidney cells, improving the antioxidative enzymic and non-enzymic capacities.
Waste and Biomass Valorization published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Computed Properties of 30931-67-0.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica