Tsuruoka, Akihiko published the artcileSynthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives, Recommanded Product: 5-Chlorothiazolo[5,4-b]pyridin-2-amine, the publication is Chemical & Pharmaceutical Bulletin (1998), 46(4), 623-630, database is CAplus and MEDLINE.
A series of novel thiazole-containing triazole antifungals, I (R1 = Ph, 4-FC6H4, Q, etc.) and II (X = CH, N, Y = Cl, F, CSNH2, etc.), was synthesized and evaluated for antifungal activity against a variety of clin. isolated pathogenic fungi in vitro and against systemic candidosis in vivo. These compounds showed potent antifungal activities in vitro and in vivo. In particular, (2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1H-1 ,2,4-triazol-1-yl)-2-butanol (ER-30346) showed potent and well-balanced in vitro activities and potent in vivo efficacy, and had a good safety profile.
Chemical & Pharmaceutical Bulletin published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C9H21NO3, Recommanded Product: 5-Chlorothiazolo[5,4-b]pyridin-2-amine.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica