Zhao, Haiwei published the artcile[Ph4P]+[Cu(CF2H)2]–: A Powerful Difluoromethylating Reagent Inspired by Mechanistic Investigation, Category: thiazole, the publication is Angewandte Chemie, International Edition (2022), 61(42), e202210151, database is CAplus and MEDLINE.
The quest of the active species in copper-mediated difluoromethylation of aryl halides led to the discovery of a powerful difluoromethylating reagent [Ph4P]+[Cu(CF2H)2]–. [Ph4P]+[Cu(CF2H)2]– complex was able to difluoromethylate a variety of electrophiles including electron-deficient and electron-rich aryl iodides, heteroaryl iodides, activated heteroaryl bromides, chloride and aryl bromides with a directing group, as well as other electrophiles such as alkenyl iodide, benzyl bromides, allyl bromides, alkyl iodide, allyl carbonates and acid chloride. In addition, in the presence of an oxidant, [Ph4P]+[Cu(CF2H)2]– complex reacted with various lithium nbutyl arylboronic acid pinacol esters, alkyne and heteroarene. Moreover, [Ph4P]+[Cu(CF2H)2]– complex could transmetalate the difluoromethyl reagent to other metals such as [Ph4P]+[CuCl2]– complex and [(DPPF)PdCl2].
Angewandte Chemie, International Edition published new progress about 791614-90-9. 791614-90-9 belongs to thiazole, auxiliary class Boronate Esters,Boronic acid and ester,Boronic acid and ester, name is 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole, and the molecular formula is C14H14N2O2, Category: thiazole.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica