Zhao, Yu-Qin et al. published their research in Journal of Functional Foods in 2019 | CAS: 63208-82-2

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Related Products of 63208-82-2

Fucoxanthin attenuates doxorubicin-induced cardiotoxicity via anti-oxidant and anti-apoptotic mechanisms associated with p38, JNK and p53 pathways was written by Zhao, Yu-Qin;Zhang, Lun;Zhao, Guo-Xu;Chen, Yin;Sun, Kun-Lai;Wang, Bin. And the article was included in Journal of Functional Foods in 2019.Related Products of 63208-82-2 The following contents are mentioned in the article:

Doxorubicin (DOX) is a commonly used anthracycline in treatments of leukemia, lymphoma and breast cancer in humans and has been limited by its cardiotoxicity, which is manifested congestive heart failure in the worst condition. The present study showed that the marine carotenoid of fucoxanthin could exert cardioprotective effect against the DOX-induced injury in ICR mice. And then, the protective effects and mechanisms of fucoxanthin on DOX-induced injury of neonatal rat cardiomyocytes were investigated. The results demonstrated that fucoxanthin significantly reduced mice toxic death triggered by DOX. The protective effects were also showed by the suppression of apoptotic cell death in cardiomyocytes. Further study revealed that fucoxanthin-produced suppression of MAPK activated by DOX was involved in the cardioprotection. The findings confirmed the cardioprotective effect of fucoxanthin against DOX-induced cardiotoxicity by protecting myocardial cells from lipid peroxidation and apoptosis, which would likely result in an increased therapeutic window of DOX in cancer therapy. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Related Products of 63208-82-2).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Related Products of 63208-82-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica