Large-scale screening of molecules involved in virus-host interaction by specific compounds in Cherax quadricarinatus hematopoietic tissue cells was written by Lin, Wenyang;Guo, Guangran;Zou, Chenchen;Shi, Hong;Ruan, Lingwei. And the article was included in Aquaculture in 2020.Related Products of 315703-52-7 The following contents are mentioned in the article:
White spot syndrome virus is one of the major pathogens that seriously threaten crustacean aquaculture. However, knowledge about the mol. mechanism of virus-host interaction remains limited. In the present study, a library containing 303 compounds targeting specific mols. was used for large-scale screening for the first time. Cherax quadricarinatus hematopoietic tissue cells were used in the present study. Combining the anal. of viral infection and cell toxicity test, 30 compounds were demonstrated to be effective. Their targeted mols. were involved in the regulation of a variety of cell signaling pathways and participated in several cellular processes, such as Hedgehog and NF-κB cell signaling pathway and regulation of cellular ions. The present study provides valuable insights into the mol. mechanism of the viral pathogenesis and host immunity, and will help to advance disease control. This study involved multiple reactions and reactants, such as N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7Related Products of 315703-52-7).
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Related Products of 315703-52-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica