Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C was written by Storer, R. Ian;Takemoto, Toshiyasu;Jackson, Philip S.;Brown, Dearg S.;Baxendale, Ian R.;Ley, Steven V.. And the article was included in Chemistry – A European Journal in 2004.Recommanded Product: 4-(Bromomethyl)-2-methylthiazole The following contents are mentioned in the article:
The total synthesis of the cytotoxic antitumor natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatog. purification The enantioselective preparation of 3 key fragments heptanone I, (S)-2-methyl-6-heptenal, and thiazole II along with their elaboration via diastereoselective coupling into epothilone C is presented. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Recommanded Product: 4-(Bromomethyl)-2-methylthiazole).
4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Recommanded Product: 4-(Bromomethyl)-2-methylthiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica