Evers, Britta et al. published their research in Bioorganic & Medicinal Chemistry in 2005 | CAS: 74704-39-5

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Related Products of 74704-39-5

Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues was written by Evers, Britta;Ruehter, Gerd;Berg, Martina;Dodge, Jeffrey A.;Hankotius, Dirk;Hary, Ulrike;Jungheim, Louis N.;Mest, Hans-Juergen;de la Nava, Eva-Maria Martin;Mohr, Michael;Muehl, Brian S.;Petersen, Soenke;Sommer, Birgit;Riedel-Herold, Grit;Tebbe, Mark J.;Thrasher, Kenneth J.;Voelkers, Silke. And the article was included in Bioorganic & Medicinal Chemistry in 2005.Related Products of 74704-39-5 The following contents are mentioned in the article:

A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-D-Ser-aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the Ph ring has been investigated, as well as replacements for the benzyl group and for the AIB residue. A number of modifications resulted in enhanced potency over the parent benzyl-D-Ser-AIB derivative This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Related Products of 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Related Products of 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica