Brands, Michael et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2005 | CAS: 74704-39-5

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Electric Literature of C5H6BrNS

Novel, selective indole-based ECE inhibitors: Lead optimization via solid-phase and classical synthesis was written by Brands, Michael;Ergueden, Jens-Kerim;Hashimoto, Kentaro;Heimbach, Dirk;Schroeder, Christian;Siegel, Stephan;Stasch, Johannes-Peter;Weigand, Stefan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Electric Literature of C5H6BrNS The following contents are mentioned in the article:

A novel class of indole-based endothelin-converting enzyme (ECE) inhibitors was identified by high throughput screening. Systematic optimization of this compound class by means of classical and solid-phase chem. is reported. Optimized compounds with a bisarylamide side chain at the 2-position of the indole skeleton exhibit low-nanomolar activity on ECE. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Electric Literature of C5H6BrNS).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Electric Literature of C5H6BrNS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica