35272-15-2, 2-Methylthiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General Procedure: To a 100 mL round bottom flask equipped with a stir bar were added 2- methyl-l,3-thiazole-4-carboxylic acid (1.0 g, 6.98 mmol), potassium carbonate (3.86 g, 27.9 mmol), N,N-dimethylformamide (20 mL) and iodomethane (0.52 mL 8.38 mmol). The reaction mixture was stirred at room temperature over the weekend, diluted with ethyl acetate (100 mL) and washed with water (100 mL). The aqueous layer was then extracted with ethyl acetate (3×75 mL). The combined organic layer was washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified on silica gel using hexanes:ethyl acetate = 80:20 to 50:50 in a gradient fashion, to give the desired product as an off-white solid (1.06 g, 97 percent). 1H NMR (300 MHz, CDCl3): delta 8.06 (s, IH), 3.95 (s, 3H), 2.78 (s, 3H).
As the paragraph descriping shows that 35272-15-2 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/87135; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica