Muri, Estela Maris F. published the artcileDesign and synthesis of heterocyclic hydroxamic acid derivatives as inhibitors of Helicobacter pylori urease, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate, the publication is Synthetic Communications (2003), 33(12), 1977-1995, database is CAplus.
Helicobacter pylori produces ammonia to help counter the acidic environment in the human stomach. The production of ammonia, essential for the microorganism’s survival and virulence, is the product of enzymic conversion of urea by the H. pylori’s urease. Inhibition of urease activity by dipeptide hydroxamic acids has previously been demonstrated using a variety of fluorides, thiols and hydroxamic acids. Studies employing computer-aided drug design techniques have been utilized to suggest a novel series of heterocyclic hydroxamic acid derivatives as potential urease inhibitors. Heterocyclic compounds such as I, II, III, and IV have been designed, synthesized, and preliminarily tested as dipeptide mimics which offer a structure that is more biol. stable than that of the reported dipeptide inhibitors.
Synthetic Communications published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica