New explortion of 120237-76-5

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: 5-Methylthiazole-4-carboxylic acid. In my other articles, you can also check out more blogs about 120237-76-5

120237-76-5, Name is 5-Methylthiazole-4-carboxylic acid, molecular formula is C5H5NO2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 120237-76-5, name: 5-Methylthiazole-4-carboxylic acid

This Letter describes the further lead optimization of the VU0486321 series of mGlu1 positive allosteric modulators (PAMs), focused on addressing the recurrent issue of plasma instability of the phthalimide moiety. Here, we evaluated a number of phthalimide bioisosteres, and ultimately identified isoindolinones as the ideal replacement that effectively address plasma instability, while maintaining acceptable mGlu1 PAM potency, DMPK profile, CNS penetration and mGluR selectivity.

This Letter describes the further lead optimization of the VU0486321 series of mGlu1 positive allosteric modulators (PAMs), focused on addressing the recurrent issue of plasma instability of the phthalimide moiety. Here, we evaluated a number of phthalimide bioisosteres, and ultimately identified isoindolinones as the ideal replacement that effectively address plasma instability, while maintaining acceptable mGlu1 PAM potency, DMPK profile, CNS penetration and mGluR selectivity.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: 5-Methylthiazole-4-carboxylic acid. In my other articles, you can also check out more blogs about 120237-76-5

Reference£º
Thiazole | C3H6526NS – PubChem,
Thiazole | chemical compound | Britannica