Kumar, Nag S. published the artcileDesign and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group for photo-affinity labeling, Product Details of C4H5NS2, the publication is Bioorganic & Medicinal Chemistry (2009), 17(15), 5388-5395, database is CAplus and MEDLINE.
A novel radioisotope-free photo-affinity probe containing the 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group was designed and synthesized. This very compact functionality is envisaged to allow photochem.-induced coupling of a compound to its target followed by click reaction coupling with an azido-biotin reagent in order to facilitate purification of the labeled target. In a proof-of-concept study we have shown that 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group could be photolyzed to efficiently furnish its methanol adduct and that the generated highly unstable carbene does not react with the neighboring acetylene moiety. A subsequent click reaction with biotin N-(2-azidoethyl) amide proceeded smoothly to give a triazole regioselectively. This chem. probe should thus be of unique value for facilitating identification of the mol. structure of the target of a bioactive compound
Bioorganic & Medicinal Chemistry published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Product Details of C4H5NS2.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica