Yanachkov, Ivan published the artcileSelf-neutralizing oligonucleotides with enhanced cellular uptake, Product Details of C5H7N3S3, the publication is Organic & Biomolecular Chemistry (2017), 15(6), 1363-1380, database is CAplus and MEDLINE.
There is tremendous potential for oligonucleotide (ON) therapeutics, but low cellular penetration due to their polyanionic nature is a major obstacle. We addressed this problem by developing a new approach for ON charge neutralization in which multiple branched charge-neutralizing sleeves (BCNSs) are attached to the internucleoside phosphates of ON by phosphotriester bonds. The BCNSs are terminated with pos. charged amino groups, and are optimized to form ion pairs with the neighboring phosphate groups. The new modified ONs can be prepared by standard automated phosphoramidite chem. in good yield and purity. They possess good solubility and hybridization properties, are not involved in non-standard intramol. aggregation, have low cytotoxicity, adequate chem. stability, improved serum stability, and above all, display significantly enhanced cellular uptake. Thus, the new ON derivatives exhibit properties that make them promising candidates for the development of novel therapeutics or research tools for modulation of the expression of target genes.
Organic & Biomolecular Chemistry published new progress about 1192027-04-5. 1192027-04-5 belongs to thiazole, auxiliary class Other Aliphatic Heterocyclic,Amine, name is N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, and the molecular formula is C8H5IO, Product Details of C5H7N3S3.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica