Akerfeldt, Stig’s team published research in Journal of Medicinal Chemistry in 13 | CAS: 92-36-4

Journal of Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Akerfeldt, Stig published the artcileIn vivo antiviral effects of benzothiazole derivatives against various influenza A2 strains, Application In Synthesis of 92-36-4, the publication is Journal of Medicinal Chemistry (1970), 13(5), 1012-13, database is CAplus and MEDLINE.

Seventeen derivatives of benzothiazole were investigated for antiviral activity against various influenza A2 strains in mice. Aminoadamantane was used as an internal standard in the experiments 2-Aminobenzothiazole and 2-amino-4-chlorobenzothiazole gave a protective effect comparable to, or better than, that found for aminoadamantane. Small variations in the structure of these 2 compounds caused a complete disappearance of the antiviral effect. To be effective the active compounds had to be administered in near-toxic doses. All 17 compounds were also tested for antiviral effect against rhino virus 33342, adeno virus 3, and herpes simplex virus. Significant antiviral effect could not be demonstrated for any compound in vitro.

Journal of Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica