Mor, Satbir published the artcileSynthesis, Type II diabetes inhibitory activity, antimicrobial evaluation and docking studies of indeno[1,2-c]pyrazol-4(1H)-ones, HPLC of Formula: 95-24-9, the publication is Medicinal Chemistry Research (2020), 29(1), 46-62, database is CAplus and MEDLINE.
A convenient and efficient synthesis of indeno[1,2-c]pyrazol-4(1H)-ones I (R1 = Me, i-Pr, i-butyl; R2 = H, Me, Cl, etc.) by the reaction of a variety of 2-acyl-(1H)-indene-1,3(2H)-diones and 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substitutedbenzo[d]thiazoles in the presence of glacial acetic acid in good yields is reported. All the synthesized indeno[1,2-c]pyrazol-4(1H)-ones I were assayed for their in vitro Type II diabetes inhibitory activity by using Acarbose as standard drug and in vitro antimicrobial activity utilizing Streptomycin and Fluconazole as reference drugs. Among the synthesized derivatives, I (R1 = Me; R2 = Br) (IC50 = 6.71 μg/mL) was found to be more potent against α-glucosidase enzyme as compared with the standard Acarbose (IC50 = 9.35 μg/mL) and I (R1 = i-propyl; R2 = Cl) (IC50 = 11.90 μg/mL) exhibited good inhibitory activity against α-amylase enzyme as compared with the standard Acarbose (IC50 = 22.87 μg/mL). Also, all the titled compounds showed good antimicrobial activity. In addition, in vitro α-glucosidase and α-amylase inhibition were supported by docking studies performed on the derivatives I (R1 = Me, i-butyl; R2 = Br) resp.
Medicinal Chemistry Research published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 95-24-9.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica