Feng, Zewang published the artcileSynthesis of 2-(2-benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid, COA of Formula: C6H8N2O2S, the publication is Zhongguo Kangshengsu Zazhi (2007), 32(10), 604-607, 635, database is CAplus.
2-(2-Benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid (1), the key intermediate of ceftibuten, was prepared from Me (2-aminothiazol-4-yl) acetate, which could be easily bought in China through a three-step reaction of amino group protection, Michael addition elimination and selective esterification with an overall yield of 63.0%. This facile and lower-cost process was suitable for industrial production
Zhongguo Kangshengsu Zazhi published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, COA of Formula: C6H8N2O2S.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica