Karskela, Marika published the artcileSynthesis and Cellular Uptake of Fluorescent Labeled Multivalent Hyaluronan Disaccharide Conjugates of Oligonucleotide Phosphorothioates, HPLC of Formula: 1192027-04-5, the publication is Bioconjugate Chemistry (2008), 19(12), 2549-2558, database is CAplus and MEDLINE.
Clustered hyaluronan disaccharides were studied as mediators of cellular delivery of antisense oligonucleotides through receptor-mediated endocytosis. For this purpose, a synthetic route for preparation of an appropriately protected hyaluronic acid dimer bearing an aldehyde tether I was devised. Up to three non-nucleosidic phosphoramidite building blocks, each bearing two phthaloyl protected aminooxy groups, were then inserted into the 3′-terminus of the desired phosphorothioate oligodeoxyribonucleotide, and 6-FAM phosphoramidite was introduced into the 5′-terminus. After completion of the chain assembly, the aldehyde-tethered sugar ligands were attached to the deprotected aminooxy functions by on-support oximation. Three fluorescein-labeled phosphorothioate oligonucleotide glycoconjugates containing two, four, or six hyaluronan disaccharides were prepared The influence of the hyaluronan moieties on the cellular uptake of the thiolated oligonucleotides was tested in a cell line expressing the hyaluronan receptor CD44. Specific uptake was not detected with this combination of multiple hyaluronan disaccharides.
Bioconjugate Chemistry published new progress about 1192027-04-5. 1192027-04-5 belongs to thiazole, auxiliary class Other Aliphatic Heterocyclic,Amine, name is N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, and the molecular formula is C5H7N3S3, HPLC of Formula: 1192027-04-5.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica