Novel 12N-substituted matrinanes as potential anti-coxsackievirus agents was written by Li, Ying-Hong;Tang, Sheng;Li, Yu-Huan;Cheng, Xin-Yue;Zhang, Xin;Wang, Yan-Xiang;Su, Feng;Song, Dan-Qing. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Electric Literature of C6H7ClN2O3S2 This article mentions the following:
A series of novel 12N-substituted matrinane derivatives were synthesized and evaluated for their activities against coxsackievirus type B3 (CVB3) taking compound I as the lead. SAR anal. indicated that the introduction of a suitable heteroaromatic ring on the 12N-atom might be beneficial for the activity. Among them, compound II exhibited the highest potency against all CVB serotypes as well as CVA16 with IC50 values ranging from 2.02 μM to 7.41 μM, indicating a broad-spectrum anti-coxsackieviruse effect. Furthermore, compound II demonstrated a good safety profile in vivo. Thus, we consider 12N-substituted matrinanes to be a promising family of anti-coxsackievirus agents, and compound II to be a promising drug candidate in the treatment of various diseases related to coxsackievirus infection. In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9Electric Literature of C6H7ClN2O3S2).
2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Electric Literature of C6H7ClN2O3S2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica