Synthesis of some thiazole Schiff bases and their derivatives was written by Dash, B.;Patra, M.;Mohapatra, P. K.. And the article was included in Journal of the Indian Chemical Society in 1985.Category: thiazole This article mentions the following:
Twenty-six thiazole Schiff bases I [R1, R2 = (un)substituted Ph; R3 = (un)substituted Ph, 2-hydroxynaphthyl] were prepared in 58-78% yield by refluxing a mist. of the appropriate aminothiazole and aldehyde in EtOH in the presence of piperidine. Cycloaddition of the Schiff bases with thioglycolic acid in C6H6 at reflux gave the thiazolidinones II in 65-77% yield (17 compounds). Reaction of I with cyclohexanone in EtOH at reflux in the presence of HCl gave the [(oxocyclohexy)methyl]amino derivatives III in 58-76% yields (13 compounds). All the compound prepared showed antifungal activity against Curvularia species. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Category: thiazole).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Category: thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica