Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K was written by Barrett, David G.;Catalano, John G.;Deaton, David N.;Long, Stacey T.;Miller, Larry R.;Tavares, Francis X.;Wells-Knecht, Kevin J.;Wright, Lois L.;Zhou, Hui-Qiang Q.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Electric Literature of C4H6N2S This article mentions the following:
An orally available series of ketoamide-based inhibitors of cathepsin K has been identified. Starting from a potent inhibitor with poor oral bioavailability, modifications to P1 and P1‘ elements led to enhancements in solubility and permeability. These improvements resulted in orally available cathepsin K inhibitors. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Electric Literature of C4H6N2S).
Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Electric Literature of C4H6N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica