A new and efficient synthesis of 2-aminobenzothiazoles derivatives from o-nitroaniline was written by Mirza, Behrooz;Mirzazadeh, Roghieh;Zeeb, Mohsen. And the article was included in Journal of Chemical Research in 2013.Computed Properties of C13H10N2S This article mentions the following:
A novel synthesis of 2-aminobenzothiazoles from a transition-metal-free reaction between aryl isothiocyanates and o-nitroaniline in the presence of K2CO3 was reported. The newly developed method is an efficient and cost-effective approach to synthesize 2-aminobenzothiazoles. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Computed Properties of C13H10N2S).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Computed Properties of C13H10N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica