A rat model of chemical-induced polycystic kidney disease with multistage tumors was written by Ito, Fumio;Toma, Hiroshi;Yamaguchi, Yutaka;Nakazawa, Hayakazu;Onitsuka, Shiro;Hashimoto, Yasunobu. And the article was included in Nephron in 1998.Application In Synthesis of 4,5-Diphenylthiazol-2-amine This article mentions the following:
The effect was examined of N-nitrosomorpholine (NNM) in rats bearing diphenylthiazole (DPT)-induced renal cysts. Sprague-Dawley rats were divided into 4 groups: DPT/NNM, DPT, NNM, and nontreated groups. DPT was administered throughout the exptl. period and NNM was given from wk 4-7 after the start of the experiment At wk 39-48, multiple cystic changes were observed in all the DPT-treated rats in DPT and DPT/NNM groups and were absent in almost all other rats. Solid adenomatous lesions were observed in 77.7% rats in the DPT/NNM and in 30% rats in the NNM group. Cystic adenomatous lesions were found in 44.4% in the DPT/NNM group exclusively. Combined DPT and NNM administration to rats produced an animal model showing neoplastic changes in renal cysts resembling microscopically renal cancer lesions in human acquired cystic disease of the kidney (on hematoxylin and eosin staining). In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Application In Synthesis of 4,5-Diphenylthiazol-2-amine).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Application In Synthesis of 4,5-Diphenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica