Schiff bases in heterocyclic synthesis: synthesis of some new heterocycles of pharmaceutical interest was written by El-Ablak, F. Z.;Etman, H. A.;Metwally, M. A.. And the article was included in Zhonghua Yaoxue Zazhi in 1993.Reference of 6318-74-7 This article mentions the following:
Treating aminothiazoles I (R1 = H, Ph, R2 = H, Ph, substituted Ph) with salicylic acid derivative II gave intermediate Schiff bases which underwent reductive cyclization with NaNB4 to give thiazoloquinazolines III. Amination of II by R2NH2 (R2 = Ph, Et) gave the corresponding Schiff bases which were cyclized by HSCH2CO2H to give thiazolidinones IV and by ClCH2COCl to give azetidinone V. Addnl. obtained were benzoisoquinoline and pyridoquinazoline derivatives In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Reference of 6318-74-7).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Reference of 6318-74-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica