Diphenylthiazole-induced changes in renal ultrastructure and enzymology: toxicologic mechanisms in polycystic kidney disease? was written by Hjelle, J. T.;Hjelle, J. J.;Maziasz, T. J.;Carone, F. A.. And the article was included in Journal of Pharmacology and Experimental Therapeutics in 1987.Recommanded Product: 6318-74-7 This article mentions the following:
Renal cystic disease was chem. induced in rats by feeding 2-amino-4,5-diphenylthiazole (DPT)(I) for up to 4 wk. After 4 days of feeding, DPT had induced a 4-fold increase in total urine output relative to diet-restricted control groups. Both groups maintained, but did not gain, weight during the feeding schedule. Cyst formation was localized to the medullary collecting tubules. Relative to diet-restricted controls, rats fed DPT exhibited diminished renal and hepatic catalase activity, but elevated activity for UDP-glucuronosyltransferase. Medulla showed an increase in the specific activities of the enzymes galactosyltransferase and sulfatase B. These enzymol. findings correlated with ultrastructural observations of a loss of peroxisomes, proliferation of endoplasmic reticulum, and enlargement of the Golgi apparatus Serum and urinary levels of inorganic sulfate were significantly increased in DPT-fed rats relative to controls. Tissue levels of UDP-glucuronic acid and adenosine 3′-phosphate 5′-phosphosulfate were not depressed by DPT feeding. Thus, DPT-induced cyst formation and loss of staining for glycosaminoglycans does not involve gross depletions of UDP-glucuronic acid and adenosine 3′-phosphate 5′-phosphosulfate, mutual cosubstrates for Phase II drug conjugation reactions, and glycosaminoglycan synthesis. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Recommanded Product: 6318-74-7).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 6318-74-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica