A Novel Route to Substituted 2-(N-Arylamino)benzothiazoles via Iron-Promoted C-S Bond Formation was written by Pinapati, Srinivasa Rao;Mandapati, Usha Rani;Tamminana, Ramana;Rudraraju, Ramesh Raju. And the article was included in ChemistrySelect in 2019.Computed Properties of C13H10N2S This article mentions the following:
The synthesis of 2-(N-arylamino)benzothiazoles I (R = Bu, cyclohexyl, 2-nitrophenyl, etc.; R1 = H, 5-Me, 7-NO2, etc.) has been demonstrated in the presence of transition metal under mild reaction conditions. In this paper, disubstituted thioureas R2NHC(S)NHR (R2 = 2-iodo-4-methylphenyl, 2-iodo-6-nitrophenyl, 4,5-dimethyl-2-iodophenyl, etc.) have also been reported from isothiocyanates R2NCS at room temperature Subsequently, C-S cross-coupling reaction was described for the construction of benzothiazoles I using cheap, readily available and air stable iron catalyst. Moreover, no other byproducts could be observed except target products. Furthermore, control experiments were performed for reveal the mechanism. In addition, a broad range of substrate scope has been explored. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Computed Properties of C13H10N2S).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Computed Properties of C13H10N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica