Plumbophosphates as oxidizing agents in the preparation of benzimidazoles, benzothiazoles, and benzoxazoles was written by El-Meligy, Mahmoud S. A.;Mohamed, Saoud A.. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1974.COA of Formula: C13H10N2S This article mentions the following:
H2[Pb(H2PO4)2(HPO4)2] or its mixture with Pb-(H2PO4)2 were used as oxidizing agents in the cyclization of the Schiff bases I [Rn = e.g. H, 5-Cl, 5,4-Cl(O2N), or 3,5-(O2N)2; R1 = e.g. Me, Ph, NHPh, or C6H4NO2-4] or 2-H2NC6H4N:C-HPh or of R2C6H4NHCSR3 (R2 = H, 2- or 4-Br, 2-Me, 2-or 4-O2N, or 4-Cl; R3 = NH2, C1-6 alkylamino, NHPh, NHC6H4-Cl-2, NMe2, or Ph) to give benzoxazoles (II), 2-phenylbenzimid-azole (III), or benzothiazoles (IV), resp. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6COA of Formula: C13H10N2S).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.COA of Formula: C13H10N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica