Leiris, Simon et al. published their research in ACS Medicinal Chemistry Letters in 2021 | CAS: 55661-33-1

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Application of 55661-33-1

Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors was written by Leiris, Simon;Davies, David T.;Sprynski, Nicolas;Castandet, Jerome;Beyria, Lilha;Bodnarchuk, Michael S.;Sutton, Jonathan M.;Mullins, Toby M. G.;Jones, Mark W.;Forrest, Andrew K.;Pallin, T. David;Karunakar, Paduri;Martha, Sathish Kumar;Parusharamulu, Battu;Ramula, Ramesh;Kotha, Venkatesh;Pottabathini, Narender;Pothukanuri, Srinivasu;Lemonnier, Marc;Everett, Martin. And the article was included in ACS Medicinal Chemistry Letters in 2021.Application of 55661-33-1 This article mentions the following:

Novel therapies are required to treat chronic bacterial infections in cystic fibrosis (CF) sufferers. The most common pathogen responsible for these infections is Pseudomonas aeruginosa, which persists within the lungs of CF sufferers despite intensive antibiotic treatment. P. aeruginosa elastase (also known as LasB or pseudolysin) is a key virulence determinant that contributes to the pathogenesis and persistence of P. aeruginosa infections in CF patients. The crucial role of LasB in pseudomonal virulence makes it a good target for the development of an adjuvant drug for CF treatment. Herein we discuss the discovery of a new series of LasB inhibitors by virtual screening and computer assisted drug design (CADD) and their optimization leading to compounds 29 and 39 (Ki = 0.16μM and 0.12μM, resp.). In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Application of 55661-33-1).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Application of 55661-33-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica