Behrens, Otto K. et al. published their research in Archives of Biochemistry in 1950 | CAS: 55661-33-1

Inhibitors for penicillinase was written by Behrens, Otto K.;Garrison, Lynette. And the article was included in Archives of Biochemistry in 1950.SDS of cas: 55661-33-1 This article mentions the following:

One of the mechanisms by which bacteria overcome or prevent the inhibitory action of penicillin (I) involves penicillinase (II) which forms penicilloic acid. Hence, inhibitors for II might be capable of extending the antibiotic action of I to some organisms not susceptible to the antibiotic. Tests on anti-II activity have been performed manometrically (cf. C.A. 43, 3489i) with compounds structurally related to a portion of the I mol. 2-Benzylimidazole (III), 2-methylimidazole (IV), 2-aminomethylthiazole (V), benzylpenicillic acid, p-chlorobenzoyl-DL-seryl-DL-valine, histamine, 2-propyl-4-thiazolidinecarboxylic acid, pencillamine (VI), thiolthreonine and cysteine exhibited marked anti-II activity. When certain of these compounds were tested for their ability to enhance the effectiveness of I on a II-producing organism, their efficacy did not parallel that in the anti-II test. VI markedly potentiated the activity of I but III, IV, and V had little or no effect. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1SDS of cas: 55661-33-1).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.SDS of cas: 55661-33-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica