One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles was written by Guo, Shanshan;Zhao, Donghong;Zhu, Yue;Yu, Yongping;Chen, Wenteng;Zhang, Guolin. And the article was included in Synthetic Communications in 2017.Recommanded Product: 6318-74-7 This article mentions the following:
Substituted 2-aminothiazoles have been synthesized from α-nitro-epoxides, cyanamide, and sodium sulfide through a facile, three-component, and ecofriendly protocol with good to excellent yields [e.g., nitro epoxide I + cyanamide + Na2S.9H2O → thiazole II (up to 88%)]. This reaction was achieved at room temperature without any additives. A possible mechanism has also been proposed. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Recommanded Product: 6318-74-7).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Recommanded Product: 6318-74-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica