Encinas, Lourdes et al. published their research in Journal of Medicinal Chemistry in 2014 | CAS: 55661-33-1

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Application In Synthesis of Thiazol-2-ylmethanamine

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA was written by Encinas, Lourdes;O’Keefe, Heather;Neu, Margarete;Remuinan, Modesto J.;Patel, Amish M.;Guardia, Ana;Davie, Christopher P.;Perez-Macias, Natalia;Yang, Hongfang;Convery, Maire A.;Messer, Jeff A.;Perez-Herran, Esther;Centrella, Paolo A.;Alvarez-Gomez, Daniel;Clark, Matthew A.;Huss, Sophie;O’Donovan, Gary K.;Ortega-Muro, Fatima;McDowell, William;Castaneda, Pablo;Arico-Muendel, Christopher C.;Pajk, Stane;Rullas, Joaquin;Angulo-Barturen, Inigo;Alvarez-Ruiz, Emilio;Mendoza-Losana, Alfonso;Ballell Pages, Lluis;Castro-Pichel, Julia;Evindar, Ghotas. And the article was included in Journal of Medicinal Chemistry in 2014.Application In Synthesis of Thiazol-2-ylmethanamine This article mentions the following:

Tuberculosis (TB) is one of the world’s oldest and deadliest diseases, killing a person every 20 s. InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis, is the target of the frontline antitubercular drug isoniazid (INH). Compounds that directly target InhA and do not require activation by mycobacterial catalase peroxidase KatG are promising candidates for treating infections caused by INH resistant strains. The application of the encoded library technol. (ELT) to the discovery of direct InhA inhibitors yielded compound I endowed with good enzymic potency but with low antitubercular potency. This work reports the hit identification, the selected strategy for potency optimization, the structure-activity relationships of a hundred analogs synthesized, and the results of the in vivo efficacy studies performed with the lead compound II. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Application In Synthesis of Thiazol-2-ylmethanamine).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Application In Synthesis of Thiazol-2-ylmethanamine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica