CP6679, a new injectable cephalosporin. Part 1: Synthesis and structure-activity relationships was written by Tsushima, M.;Iwamatsu, K.;Umemura, E.;Kudo, T.;Sato, Y.;Shiokawa, S.;Takizawa, H.;Kano, Y.;Kobayashi, K.;Ida, T.;Tamura, A.;Atsumi, K.. And the article was included in Bioorganic & Medicinal Chemistry in 2000.Recommanded Product: 55661-33-1 This article mentions the following:
A series of cephalosporins bearing a 5,5-fused ring system, an (imidazo[5,1-b]thiazolium-6-yl)methyl group, at the C-3 position were synthesized and evaluated for in vitro antibacterial activities. CP6679 (I) and its analogs showed potent antibacterial activities against Gram-pos. and Gram-neg. bacteria, including Pseudomonas aeruginosa. They were also highly active against methicillin-resistant Staphylococcus aureus (MRSA). I showed more potent antibacterial activity than ceftazidime (CAZ) or cefpirome (CPR) against Pseudomonas aeruginosa and MRSA. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Recommanded Product: 55661-33-1).
Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Recommanded Product: 55661-33-1
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica