Asymmetric Synthesis of Heterocyclic Chloroamines and Aziridines by Enantioselective Protonation of Catalytically Generated Enamines was written by McLean, Liam A.;Ashford, Matthew W.;Fyfe, James W. B.;Slawin, Alexandra M. Z.;Leach, Andrew G.;Watson, Allan J. B.. And the article was included in Chemistry – A European Journal in 2022.Category: thiazole This article mentions the following:
A method for the synthesis of chiral vicinal chloroamines RCH(Cl)CH2NHR1 [R = 2-quinolyl, quinazolin-2-yl, 1,3-benzothiazol-2-yl, etc.; R1 = Ph, 4-MeC6H4, benzothiophen-5-yl, etc.] via asym. protonation of catalytically generated prochiral chloroenamines using chiral Bronsted acids was reported. The process was highly enantioselective, with the origin of asymmetry and catalyst substituent effects elucidated by DFT calculations The utility of the method showed as an approach to the synthesis of a broad range of heterocycle-substituted aziridines I [R2 = 2-quinolyl, quinoxalin-2-yl, 5-cyano-2-pyridyl, etc.; Ar = Ph, 4-MeOC6H4, 3-BrC6H4, etc.] by treatment of the chloroamines with base in a one-pot process, as well as the utility of the process to allow access to vicinal diamines II [R3 = 4-tert-butoxycarbonylpiperazin-1-yl, morpholino, thiomorpholino]. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Category: thiazole).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Category: thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica