Gao, Ping et al. published their research in Chemical Biology & Drug Design in 2019 | CAS: 69812-29-9

2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 69812-29-9

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors was written by Gao, Ping;Wang, Xueshun;Sun, Lin;Cheng, Xiqiang;Poongavanam, Vasanthanathan;Kongsted, Jacob;Alvarez, Mar;Luczkowiak, Joanna;Pannecouque, Christophe;De Clercq, Erik;Lee, Kuo-Hsiung;Chen, Chin-Ho;Liu, Huiqing;Menendez-Arias, Luis;Liu, Xinyong;Zhan, Peng. And the article was included in Chemical Biology & Drug Design in 2019.Recommanded Product: 69812-29-9 This article mentions the following:

Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated RNase H (RNase H) remains as the only enzyme encoded within the viral genome not targeted by current antiviral drugs. In this work, we report the design, synthesis, and biol. evaluation of a novel series of galloyl derivatives with HIV-1 RNase H inhibitory activity. Most of them showed IC50s at sub- to low-micromolar concentrations in enzymic assays. The most potent compound was II-25 that showed an IC50 of 0.72 ± 0.07 μM in RNase H inhibition assays carried out with the HIV-1BH10 RT. II-25 was 2.8 times more potent than β-thujaplicinol in these assays. Interestingly, II-25 and other galloyl derivatives were also found to inhibit the HIV IN strand transfer activity in vitro. Structure-activity relationships (SAR) studies and mol. modeling anal. predict key interactions with RT residues His539 and Arg557, while providing helpful insight for further optimization of selected compounds In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9Recommanded Product: 69812-29-9).

2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 69812-29-9

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica