Visible-Light-Driven Synthesis of 4-Alkyl/Aryl-2-Aminothiazoles Promoted by In Situ Generated Copper Photocatalyst was written by Lei, Wen-Long;Wang, Tao;Feng, Kai-Wen;Wu, Li-Zhu;Liu, Qiang. And the article was included in ACS Catalysis in 2017.Electric Literature of C15H12N2S This article mentions the following:
Aryl- and alkyl-substituted 2-aminothiazoles were prepared chemoselectively by photochem. cyclocondensation of vinyl azides with ammonium thiocyanate in the presence of Cu(OAc)2 under blue (visible) light LED irradiation at ambient temperature The mechanism of the cyclocondensation was studied; bis(thiocyanato)copper(I) anion generated in situ acted as both a catalyst for photochem. generation of azirines from vinyl azides and for ring opening of the azirines with thiocyanate. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Electric Literature of C15H12N2S).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Electric Literature of C15H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica