Author: tianli

3,4,5-Trimethoxy Substitution on an N-DMBI Dopant with New N-Type Polymers: Polymer-Dopant Matching for Improved Conductivity-Seebeck Coefficient Relationship was written by Han, Jinfeng;Chiu, Arlene;Ganley, Connor;McGuiggan, Patty;Thon, Susanna M.;Clancy, Paulette;Katz, Howard E.. And the article was included in Angewandte Chemie, International Edition in 2021.Product Details of 3034-53-5 This article mentions the following:

Achieving high elec. conductivity and thermoelec. power factor simultaneously for n-type organic thermoelecs. is still challenging. By constructing 2 new acceptor-acceptor n-type conjugated polymers with different backbones and introducing the 3,4,5-trimethoxyphenyl group to form the new n-type dopant 1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1H-benzo[d]imidazole (TP-DMBI), high elec. conductivity of 11 S cm^-1 and power factor of 32渭W m^-1 K^-2 are achieved. Calculations using D. Functional Theory show that TP-DMBI presents a higher singly occupied MO (SOMO) energy level of -1.94 eV than that of the common dopant 4-(1, 3-dimethyl-2, 3-dihydro-1H-benzoimidazol-2-yl) Ph dimethylamine (N-DMBI) (-2.36 eV), which can result in a larger offset between the SOMO of dopant and LUMO (LUMO) of n-type polymers, though that effect may not be dominant. The doped polymer films exhibit higher Seebeck coefficient and power factor than films using N-DMBI at the same doping levels or similar elec. conductivity levels. Also, TP-DMBI doped polymer films offer much higher electron mobility of up to 0.53 cm² V^-1 s^-1 than films with N-DMBI doping, demonstrating the potential of TP-DMBI, and 3,4,5-trialkoxy DMBIs more broadly, for high performance n-type organic thermoelecs. In the experiment, the researchers used many compounds, for example, 2-Bromothiazole (cas: 3034-53-5Product Details of 3034-53-5).

2-Bromothiazole (cas: 3034-53-5) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Product Details of 3034-53-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Plasmid-borne AFM alleles in Pseudomonas aeruginosa clinical isolates from China was written by Chen, Minhua;Cai, Heng;Li, Yue;Wang, Nanfei;Zhang, Piaopiao;Hua, Xiaoting;Yu, Yunsong;Sun, Renhua. And the article was included in Microbiology Spectrum in 2022.Related Products of 78110-38-0 This article mentions the following:

Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a pathogen of global concern due to the fact that therapeutic drugs are limited. Metallo-尾-lactamase (MBL)-producing P. aeruginosa has become a critical part of CRPA. Alcaligenes faecalis metallo-尾-lactamase (AFM) is a newly identified subclass B1b MBL. In this study, 487 P. aeruginosa strains isolated from patients and the environment in an intensive care unit were screened for AFM alleles. Five AFM-producing strains were identified, including four AFM-2-producing strains (ST262) and one AFM-4-producing strain (ST671). AFM-2-producing strains were isolated from rectal and throat swabs, and AFM-4-producing strains were isolated from the water sink. The blaAFM-₂ carrying plasmids belonged to the IncP-2 type, while the blaAFM-₄ carrying plasmid pAR19438 was a pSTY-like megaplasmid. Plasmid pAR19438 was acquired blaAFM-₄ by the integration of the Tn1403-like transposon. All blaAFM genes were embedded in an ISCR29-blaAFM unit core module flanked by class 1 integrons. The core module of blaAFM-₂ was ISCR29-螖groL-blaAFM-₂-bleMBL-螖trpF-螖ISCR, while the core module of blaAFM-₄ was ISCR29-螖groL-blaAFM-₂-bleMBL-螖trpF-ISCR-msrB-msrA-yfcG-corA-螖ISCR. The flanking sequences of ISCR29-blaAFM units also differed. The expression of AFM-2 and AFM-4 in DH5伪 and PAO1 illustrated the same effect for the evaluation of the MICs of 尾-lactams, except for aztreonam. Identification of AFM-4 underscores that the quick spread and emerging development of mutants of MBLs require continuous surveillance in P. aeruginosa. IMPORTANCE Acquiring metallo-p尾-lactamase genes is one of the important carbapenem resistance mechanisms of P. aeruginosa. Alcaligenes faecalis metallo-尾-lactamase is a newly identified metallo-尾-lactamase, the prevalence and genetic context of which need to be explored. In this study, we identified AFM-producing P. aeruginosa strains among clin. isolates and found a new mutant of AFM, AFM-4. The blaAFM-₄ carrying plasmid pAR19438 was a pSTY-like megaplasmid, unlike the plasmids encoding other blaAFM alleles. The genetic context of blaAFM-₄ was also different. However, AFM-2 and AFM-4 had the same impacts on antibiotic susceptibility. The presence and transmission of AFM alleles in P. aeruginosa pose a challenge to clin. practice. In the experiment, the researchers used many compounds, for example, 2-((((Z)-1-(2-Aminothiazol-4-yl)-2-(((2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid (cas: 78110-38-0Related Products of 78110-38-0).

2-((((Z)-1-(2-Aminothiazol-4-yl)-2-(((2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid (cas: 78110-38-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Related Products of 78110-38-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In silico study of naphtha [1, 2-d] thiazol-2-amine with adenosine A_2A receptor and its role in antagonism of haloperidol-induced motor impairments in mice was written by Luthra, Pratibha Mehta;Prakash, Amresh;Barodia, Sandeep Kumar;Kumari, Rita;Mishra, Chandra Bhushan;Kumar, J. B. Senthil. And the article was included in Neuroscience Letters in 2009.Safety of Naphtho[1,2-d]thiazol-2-amine This article mentions the following:

Loss of dopaminergic nigrostriatal neurons in the substantia nigra leads to Parkinson’s disease (PD). Adenosine A_2A receptors (A_2ARs) have been anticipated as novel therapeutic target for PD. A_2ARs potentiate locomotor behavior and are predominantly expressed in striatum. Naphtha [1, 2-d] thiazol-2-amine (NATA), a tricyclic thiazole have been studied as new anti-Parkinsonian compound AutoDock anal. and pharmacophore study of NATA with known A_2AR antagonists explicit its efficacy as a possible adenosine receptor antagonist. In vivo pharmacol. of NATA showed reduction of haloperidol (HAL)-induced motor impairments in Swiss albino male mice. Relatively elevated levels of dopamine in NATA pre-treated mice are suggestive of its possible role as neuromodulator in PD. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Safety of Naphtho[1,2-d]thiazol-2-amine).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Safety of Naphtho[1,2-d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Thiazolylalkylamines: synthesis of congeners of imidazolylethylamines and their effects on gastric secretion was written by Vitali, T.;Impicciatore, M.;Plazzi, P. V.;Bordi, F.;Morini, G.. And the article was included in Farmaco, Edizione Scientifica in 1986.Electric Literature of C5H8N2OS This article mentions the following:

Eight 2-aminothiazolylethylamines (I, R = NH₂, NHMe, or NMe₂; R¹ and R² = H, Me; X = Y = N, S), as well as 4 related compounds unsaturated in the ring or side chain, were prepared by 3 different reaction sequences, for which the mechanisms are illustrated. Since these compounds contain the S-aminoalkylisothiourea group which, in other instances stimulates gastric secretion, they were tested for histaminic-H₂ agonist activity in vitro (isolated guinea pig fundus) and in vivo (gastric acid secretion in the cat) and for some other activities. Examination of structure-activity relations excluded the possibility that the juxtanuclear NH₂ group of the compounds interacts with the H₂ receptor; the 2-aminothiazole moiety is not pharmacol. equivalent to the 2-aminoimidazole or isothiourea groups. This strengthens the hypothesis that the flexibility of the mol. is a fundamental requirement for the H₂-stimulant properties of S-(3-dimethylaminopropyl)isothiourea and that the different behavior of 2-aminohistamine relative to 2-methylhistamine is due to the existence of a hydrophilic area in the histaminic-H₂ receptor which is capable of accepting the juxtanuclear NH₂ group of the former. In the experiment, the researchers used many compounds, for example, 2-Amino-5-(2-hydroxyethyl)thiazole (cas: 105773-93-1Electric Literature of C5H8N2OS).

2-Amino-5-(2-hydroxyethyl)thiazole (cas: 105773-93-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Electric Literature of C5H8N2OS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Formation of azomethines from 2-aminothiazoles and (heterocyclic) aromatic aldehydes was written by Hopkinson, Christopher;Meakins, George Denis;Purcell, Roberts James. And the article was included in Synthesis in 1991.HPLC of Formula: 74370-93-7 This article mentions the following:

Reexamination of previous work and new studies show that the reactions of 2-aminothiazoles with (heterocyclic) aromatic aldehydes are not straightforward; there are wide divergencies in behavior between the various amine-aldehyde pairs. Simple efficient procedures for preparing 2-(alkylideneamino)thiazole derivatives I (R¹ = H, R² = 2-thienyl, 2-furyl, Ph, 4-O₂NC₆H₄, 4-MeOC₆H₄; R¹ = Me, CMe₃, Ph, R² = 4-MeOC₆H₄, 4-Me₂NC₆H₄, 4-C₂NC₆H₄) and [bis(thiazol-2-ylamino)methyl]arenes II were developed. In the experiment, the researchers used many compounds, for example, 4-(tert-Butyl)thiazol-2-amine (cas: 74370-93-7HPLC of Formula: 74370-93-7).

4-(tert-Butyl)thiazol-2-amine (cas: 74370-93-7) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.HPLC of Formula: 74370-93-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kinase inhibitor profile for human Nek1, Nek6, and Nek7 and analysis of the structural basis for inhibitor specificity was written by Moraes, Eduardo Cruz;Meirelles, Gabriela Vaz;Honorato, Rodrigo Vargas;Brasil de Souza, Tatiana de Arruda Campos;Elisa de Souza, Edmarcia;Murakami, Mario Tyago;Lopes de Oliveira, Paulo Sergio;Kobarg, Jorg. And the article was included in Molecules in 2015.Application In Synthesis of 1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea This article mentions the following:

Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential drug targets for the treatment of cancer and other pathologies. We screened the activation loop mutant kinases hNek1 and hNek2, wild-type hNek7, and five hNek6 variants in different activation/phosphorylation statesand compared them against 85 compounds using thermal shift denaturation. We identified three compounds with significant Tm shifts: JNK Inhibitor II for hNek1(螖262-1258)-(T162A), Isogranulatimide for hNek6(S206A), andGSK-3 Inhibitor XIII for hNek7wt. Each one of these compounds was also validated by reducing the kinases activity by at least 25%. The binding sites for these compounds were identified by in silico docking at the ATP-binding site of the resp. hNeks. Potential inhibitors were first screened by thermal shift assays, had their efficiency tested by a kinase assay, and were finally analyzed by mol. docking. Our findings corroborate the idea of ATP-competitive inhibition for hNek1 and hNek6 and suggest a novel non-competitive inhibition for hNek7 in regard to GSK-3 Inhibitor XIII. Our results demonstrate that our approach is useful for finding promising general and specific hNekscandidate inhibitors, which may also function as scaffolds to design more potent and selective inhibitors. In the experiment, the researchers used many compounds, for example, 1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea (cas: 487021-52-3Application In Synthesis of 1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea).

1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea (cas: 487021-52-3) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application In Synthesis of 1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Cyclometalated Half-Sandwich Iridium Complex for Catalytic Hydrogenation of Imines and Quinolines was written by Yao, Zi-Jian;Lin, Nan;Qiao, Xin-Chao;Zhu, Jing-Wei;Deng, Wei. And the article was included in Organometallics in 2018.Category: thiazole This article mentions the following:

Several C,N-chelate cyclometalated half-sandwich iridium-based catalysts [Cp*IrCl(2-ArBztz)] (1–5, H-ArBztz = arylbenzothiazole) for imines and quinoline derivatives reduction have been prepared through metal-mediated C-H bond activation based on benzothiazole ligands. These iridium complexes exhibited high catalytic activity for hydrogenation of various types of imines with high yields. The most active catalyst was obtained from methoxy substituted complex [2, HArBztz = 2-(4-methoxyphenyl)benzothiazole] showing the catalytic TOF value of 975 h^-1 for the reduction of N-phenylacetophenoneketimine (6a). Addnl., these half-sandwich complexes also showed high efficiency for the catalytic hydrogenation of N-heterocyclic quinoline derivatives Good catalytic activity was displayed for various kinds of substrates with either electron-donating or electron-withdrawing groups. Complexes 1–5 were fully characterized by NMR, IR, and elemental anal. Mol. structures of complexes 1 (ArH = Ph) and 4 (ArH = 4-ClC₆H₄) were further confirmed by X-ray diffraction anal. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenyl)benzothiazole (cas: 6265-92-5Category: thiazole).

2-(4-Methoxyphenyl)benzothiazole (cas: 6265-92-5) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A highly efficient palladium-catalyzed desulfitative arylation of azoles with sodium arylsulfinates was written by Wang, Min;Li, Dengke;Zhou, Wei;Wang, Lei. And the article was included in Tetrahedron in 2012.Related Products of 2942-06-5 This article mentions the following:

A highly efficient palladium-catalyzed direct desulfitative arylation of azoles at C2-position has been developed using sodium arylsulfinates as aryl sources. Azoles including benzoxazoles, benzothiazoles, oxazoles, thiazoles, and 1,3,4-oxadiazoles reacted with sodium arylsulfinates smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction. In the experiment, the researchers used many compounds, for example, 6-Nitrobenzothiazole (cas: 2942-06-5Related Products of 2942-06-5).

6-Nitrobenzothiazole (cas: 2942-06-5) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Related Products of 2942-06-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis of a new [3-(4-chlorophenyl)-4-oxo-1, 3-thiazolidin-5-ylidene]acetic acid derivative was written by Szczepanski, Jacek;Tuszewska, Helena;Trotsko, Nazar. And the article was included in Molbank in 2020.Related Products of 92972-48-0 This article mentions the following:

The new I was synthesized from II using di-Me acetylenedicarboxylate as thia-Michael reaction acceptor. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorothiazole-5-carbaldehyde (cas: 92972-48-0Related Products of 92972-48-0).

2,4-Dichlorothiazole-5-carbaldehyde (cas: 92972-48-0) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 掳C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Related Products of 92972-48-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Stability study on cefotiam hydrochloride and xylitol injection formulation was written by Hu, Zhong-jie;Zhou, Lei;Miao, Pei-hong. And the article was included in Xibei Yaoxue Zazhi in 2007.Application of 66309-69-1 This article mentions the following:

This paper aims to study the stability of cefotiam hydrochloride and xylitol injection formulation. Cefotiam hydrochloride and xylitol injection formulation was placed at room temperature (25掳) for 8 h, and during this period its content change was determined by UV spectrophotometry. Its appearance, pH and particle changes were observed at the same time. It was found that cefotiam hydrochloride and xylitol injection formulation kept stable within 6 h. In the experiment, the researchers used many compounds, for example, (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1Application of 66309-69-1).

(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (cas: 66309-69-1) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Application of 66309-69-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica