Author: tianli

Liu, Jianhua; Kotrchova, Lenka; Lecuyer, Thomas; Corvis, Yohann; Seguin, Johanne; Mignet, Nathalie; Etrych, Tomas; Scherman, Daniel; Randarova, Eva; Richard, Cyrille published the artcile< Coating persistent luminescence nanoparticles with hydrophilic polymers for in vivo imaging>, Name: 4,5-Dihydrothiazole-2-thiol, the main research area is zinc gallium oxide chromium hydrophilic polymer optical property; HPMA polymer; imaging; in vivo; nanoparticles; persistent luminescence; surface coating.

Persistent luminescence nanoparticles (PLNPs) are innovative nanomaterials highly useful for bioimaging applications. Indeed, due to their particular optical properties, i.e., the ability to store the excitation energy before slowly releasing it for a prolonged period of time, they allow in vivo imaging without auto-fluorescence and with a high target to background ratio. However, as for most nanoparticles (NPs), without any special surface coating, they are rapidly opsonized and captured by the liver after systemic injection into small animals. To overcome this issue and prolong nanoparticle circulation in the bloodstream, a new stealth strategy was developed by covering their surface with poly(N-2-hydroxypropyl)methacrylamide (pHPMA), a highly hydrophilic polymer widely used in nanomedicine. Preliminary in vivo imaging results demonstrated the possibility of pHPMA as an alternative strategy to cover ZnGa2O4:Cr NPs to delay their capture by the liver, thereby providing a new perspective for the formulation of stealth NPs.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Biological imaging. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Name: 4,5-Dihydrothiazole-2-thiol.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lee, Hyojin; Kim, Ki Hun; Lee, Kwan Hyi published the artcile< Non-invasive molecular barcode assay for diagnosis of sex hormones correlated with precocious puberty>, Reference of 96-53-7, the main research area is testosterone estradiol diagnosis noninvasive mol barcode assay precocious puberty.

Precocious puberty treatment in children faces several diagnostic and therapeutic challenges. For an efficient prognosis of the disease, early diagnosis must be accompanied by properly timed treatment. Sex hormones are markers that are used to diagnose precocious puberty. Detection methods usually require multiple blood samples from the patient over a 90-120-min time interval. The test is painful and uncomfortable for children, and is relatively expensive and time-consuming. Herein, we introduce a new bio-barcode method that is a non-invasive, fast, highly-sensitive, and is capable of multiplex detection of steroid sex hormones in urine using gold nanoparticles. We compared three different barcode assay approaches to determine the barcode mols.: gel electrophoresis, fluorescence-based solution assay, and liquid chromatog.-mass spectrometry (LC-MS). The gel electrophoresis approach was cost-effective but could not quantify the absolute levels of hormones. The other methods permitted quant. comparison between samples. LC-MS displayed the highest sensitivity. For the LC-MS anal., we grafted two chem. compounds as surrogate mols. onto the surface of 50-nm gold nanoparticles. Approx. 7-9 million chem. mols. were loaded on each nanoparticle, which amplified the LC-MS signal. The LC-MS could detect hormones levels which were 10,000-fold lower than the levels detected by the conventional method. The barcode assay could determine multiple analytes simultaneously without any sample preparation step. Importantly, this is first finding that uses barcode mols.-conjugated nanoparticles to amplify the mass spectrometer signal. The result is significant as it has implications for its principle and methodol., which utilizes non-invasive procurement protocols, can be applied to not only sex hormones, but other hormones which require will ultrasensitive detection. We anticipate that our research findings, which use a painless and economic detection method, can contribute to the early and accurate diagnosis of precocious puberty.

Sensors and Actuators, B: Chemical published new progress about Diagnosis Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Reference of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ormond, Alexandra B.; Freeman, Harold S. published the artcile< Effects of substituents on the photophysical properties of symmetrical porphyrins>, Product Details of C4H3NOS, the main research area is singlet oxygen generation sym porphyrin photosensitizer; substituent effect photophys sym porphyrin derivative.

Porphyrin compounds having groups that mimic the phenolic moiety of m- and p-isomers of 5,10,15,20-tetrakis(hydroxyphenyl) porphyrin (THPP) have been synthesized along with 5,10,15,20-tetrakis(heteroaryl) porphyrins bearing 2-thienyl and 5-thiazolyl groups. Absorption and fluorescence spectroscopy, including fluorescence lifetime (τf) and quantum yield (Φf) measurements, were employed to characterize the singlet excited state of all compounds, using 5,10,15,20-tetraphenylporphyrin (H2TPP) as a standard (Φf = 0.12 in DMF). The generation of singlet oxygen by each porphyrin photosensitizer was measured as the singlet oxygen quantum yield (ΦΔ), using H2TPP as a standard (ΦΔ = 0.64 in DMF). Partition coefficients were determined using 2-octanol as the organic phase and PBS solution as the aqueous phase. Fluorescence quantum yields ranged from 0.01 to 0.18 for all compounds, with heteroaryl porphyrins having the lowest values. Singlet oxygen quantum yields ranged from 0.40 to 0.65, with heteroaryl porphyrins having the highest values, showing them to be better sensitizers than m- and p-THPP. Log P values were all >1 showing higher solubility in the 2-octanol layer.

Dyes and Pigments published new progress about Excited singlet state. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Product Details of C4H3NOS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Rezania, Jafar; Behzadi, Hadi; Shockravi, Abbas; Ehsani, Morteza; Akbarzadeh, Elahe published the artcile< Corrigendum to ""Synthesis and DFT calculations of some 2-aminothiazoles"" [J. Mol. Struct. 1157 (5) (April 2018) 300-305] [Erratum to document cited in CA168:135942]>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is aminothiazole preparation green chem DFT calculation erratum; ketone aryl thiourea cyclization iodine catalyst erratum.

In the original publication, there are errors in the affiliations section; the correction is provided here.

Journal of Molecular Structure published new progress about Alkyl aryl ketones Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nagase, Hiroshi published the artcile< Fungicides. XXII. Reaction of dimethyl acetylenedicarboxylate with dithiocarbamates, thiolcarbamates, thiosemicarbazides, and thiosemicarbazones>, Safety of 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is acetylenedicarboxylate reaction; thiocarbamate reaction acetylenedicarboxylate; thiosemicarbazide reaction acetylenedicarboxylate; thiosemicarbazone reaction acetylenedicarboxylate; thiazolidone.

Dimethyl acetylenedicarboxylate reacted readily with dithiocarbamates, thiolcarbamates, thiosemicarbazides, and thiosemicarbazones to give 4-thiazolidones [I, R = H, alkyl, PhCH2, NH2; X = S (II), O NR1 (R1 = Me, Ph, substituted-methyleneamino)]. The exo double bond of 4-thiazolidones (II) was highly reactive to dithiocarbamates to give 2,2′-dithioxo-5,5′-bi-4-thiazolidones, which were autoxidized to 2,2′-dithioxo-Δ5,5′-bi-4-thiazolidones in the presence of catalytic amount of amines.

Chemical & Pharmaceutical Bulletin published new progress about 10574-69-3. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Safety of 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Michaelis, Lars; Schinzer, Dieter published the artcile< Studies toward the total synthesis of sorangicins: a shortened synthesis of the dioxabicyclo[3.2.1]octane core>, Application In Synthesis of 171877-39-7, the main research area is sorangicin preparation antibiotic antibacterial agent.

An access to the dioxabicyclo[3.2.1]octane core of 6-methyl-8-(3,3a,8,9,10,11,12,13,14,15,18,19,22,23,25,26,28,34a-octadecahydro-11,14,15-trihydroxy-10,38-dimethyl-28-oxo-9,13-epoxy-23,26-etheno-2,5-methano-2H,5H-furo[2,3-l][1,4,14]trioxacyclotritriacontin-25-yl)-7-nonenoic acid [i.e., (+)-sorangicin A] was developed, using a keto lactone formation, a Mukaiyama-Michael reaction and an epoxide opening as the key steps. The synthesis of the target compound was achieved using (4S)-4-(phenylmethyl)-2-thiazolidinethione as a chiral auxiliary. The title compound thus formed was (8E)-2,5:3,7-dianhydro-4,6,8,9-tetradeoxy-6-methyl-9-phenyl-L-glycero-L-gluco-non-8-enitol, (8E)-2,5:3,7-dianhydro-4,6,8,9-tetradeoxy-6-methyl-9-phenyl-L-glycero-L-gluco-non-8-enose.

Synlett published new progress about Antibacterial agents. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Application In Synthesis of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pena, Stella; Scarone, Laura; Manta, Eduardo; Stewart, Lindsay; Yardley, Vanessa; Croft, Simon; Serra, Gloria published the artcile< Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity>, Category: thiazole, the main research area is peptidomimetic synthesis Microcystis aeruginosa metabolite antimalarial agent; peptide coupling oxazole thiazole macrocyclization.

The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodol. The compound exhibited good in vitro antiplasmodial activity (IC50: 0.18μM, K1, chloroquine-resistant strain).

Bioorganic & Medicinal Chemistry Letters published new progress about Antimalarials. 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nicolaou, K. C.; Leung, Gulice Y. C.; Dethe, Dattatraya H.; Guduru, Ramakrishna; Sun, Ya-Ping; Lim, Chek Shik; Chen, David Y.-K. published the artcile< Chemical Synthesis and Biological Evaluation of Palmerolide A Analogues>, Product Details of C5H6N2OS, the main research area is palmerolide A analog preparation antitumor.

Mol. design and chem. synthesis of several palmerolide A analogs allowed the first structure activity relationships (SARs) of this newly discovered marine antitumor agent. From several analogs synthesized and tested, compounds I (with a Ph substituent on the side chain) and II (lacking the C-7 hydroxyl group) were the most interesting, exhibiting approx. a 10-fold increase in potency and equipotency, resp., to the natural product. These findings point the way to more focused structure activity relationship studies.

Journal of the American Chemical Society published new progress about Antitumor agents. 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Product Details of C5H6N2OS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Crimmins, Michael T.; Azman, Adam M. published the artcile< A modular, stereoselective approach to spiroketal synthesis>, Computed Properties of 171877-39-7, the main research area is modular stereoselective synthesis spiroketal milbemycin fragment.

A highly convergent and flexible synthetic approach to stereochem. defined spiroketals is reported. Substituents can be incorporated at various positions around the spiroketal framework without significant disruption to the synthetic scheme. The approach has been exploited to prepare the spiroketal fragment of milbemycin β14.

Synlett published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Computed Properties of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Okumura, Kazuro; Ito, Akio; Saito, Hiroyuki; Nakamura, Yutaka; Shin, Chung-gi published the artcile< Dehydrooligopeptides. XIV. Syntheses of 2-[(Z)-1-aminoalken-1-yl]oxazole-4-carboxylic acid and the main common skeleton of thiostrepton peptide antibiotics A10255G and A10255J.>, Recommanded Product: Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate, the main research area is dehydrooligopeptide preparation thiostrepton peptide antibiotic intermediate.

Precursor (I) to title cyclopeptide antibiotics (II; R = Q1, Q2) is constructed from novel 2-[(Z)-1-amino-1-propen-1-yl]oxazole-4-carboxylic acids (III; R1 = Me, Me2CH, Ph; R2 = H, Me) and 2-(1-aminomethyl)- and 2[(S)-1-aminoethyl]thiazole-4-carboxylic acid residues.

Bulletin of the Chemical Society of Japan published new progress about Peptide analogs Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Recommanded Product: Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica