Author: tianli

COA of Formula: C18H24N6O6S4On October 31, 2020 ,《Synthesis of selenium-containing galactomannan-stabilized nanocomposites with particle size-sensitive antiradical activity》 appeared in Russian Chemical Bulletin. The author of the article were Lesnichaya, M. V.; Sapozhnikov, A. N.; Sukhov, B. G.. The article conveys some information:

Water-soluble hybrid nanocomposites were synthesized for the first time with the use of industrial crystalline selenium (gray powder selenium) activated in a hydrazine hydrate-alkali base-recovery system. The obtained nanocomposites consist of the selenium nanoparticles 13.0-24.0 nm in size stabilized by biocompatible natural polysaccharide galactomannan. The structures of the nanocomposites were characterized by a complex of physicochem. methods (X-ray diffraction anal., transmission electron microscopy, and IR spectroscopy). The pronounced antioxidant activity of the prepared nanocomposites against free radicals of 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt was found, and its value correlates with the particle size of selenium. The results came from multiple reactions, including the reaction of ABTS Diammonium(cas: 30931-67-0COA of Formula: C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.COA of Formula: C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Recommanded Product: ABTS DiammoniumOn March 31, 2019, Ates, Fadime; Sahin, Selin; Ilbay, Zeynep; Kirbaslar, S. I. published an article in Waste and Biomass Valorization. The article was 《A Green Valorisation Approach Using Microwaves and Supercritical CO2 for High-Added Value Ingredients from Mandarin (Citrus deliciosa Tenore) Leaf Waste》. The article mentions the following:

The present study aims to increase the efficiency of a resource from waste to health by valorization of it through cleaner, eco-friendly and less energy-consuming tech. processes such as microwave-asissted (MAE) and supercritical fluid (SFE) extractions On the other hand, optimization of the processes have been applied utilizing multivariate statistic technique such as Response surface Methodol. (RSM) in order to consider any possible interaction between variables with less number of experiments as well as to model a response affected by several variables. The outcome of the present study indicates that the optimum conditions for MAE were 275 W of microwave power together with 2 g mandarin leaf for 45 s; regarding SFE, 50 °C, 200 bar and 0.39 mL/min was found as the optimal condition to obtain the maximum yields of each dependent variable such as total phenolic material (TPM) and total flavonoid material (TFM), resp. Addnl., antioxidant activity values measured by several methods such as cupric ion reducing antioxidant capacity (CUPRAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) were correlated pos. with both TPM and TFM in the leaf extracts Furthermore, scanning electron microscope (SEM) images indicated cell wall disruption in all the treatment groups compared to untreated samples. In the experiment, the researchers used ABTS Diammonium(cas: 30931-67-0Recommanded Product: ABTS Diammonium)

ABTS Diammonium(cas: 30931-67-0) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2020,Catalysis Science & Technology included an article by Koohgard, Mehdi; Hosseinpour, Zeinab; Sarvestani, Abdollah Masoudi; Hosseini-Sarvari, Mona. Reference of 6-Chlorobenzothiazol-2-ylamine. The article was titled 《ARS-TiO2 photocatalyzed direct functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions under visible light》. The information in the text is summarized as follows:

An ARS-TiO2 photocatalyst has been prepared by a simple method through stirring a mixture of ARS and TiO2 at room temperature in the dark to extend the photocatalytic response of titanium dioxide toward the visible light spectrum. The synergic effect of ARS and TiO2 in the photocatalyst system has catalyzed direct C-H functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions. Several aromatic and heteroaromatic scaffolds (2-phenylamino-thiazoles I (R = H, 2-Cl, 4-Ph, etc.), phenols R1OH (R1 = Ph, 3-ethylphenyl, 2-formylphenyl, etc.), anilines R2C6H4N(R3)(R4) (R2 = 2-Me, 3-Cl, 3-OMe, etc.; R3 = H, Me, Et, Ph; R4 = H, Me, Et), indoles II (R5 = H, Me; R6 = H, Me; R7 = H, 5-MeO, 6-methoxycarbonyl, 5-Br, 5-Me) and pyrroles such as 1H-pyrrole and 1-methyl-1H-pyrrole) were treated with the ammonium thiocyanate at room temperature Thiocyanation of phenol and synthesis of 2-aminobenzothiazole derivatives III (R8 = Me, I, prop-1-en-2-yl, etc.) under visible light are presented.6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Reference of 6-Chlorobenzothiazol-2-ylamine) was used in this study.

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Reference of 6-Chlorobenzothiazol-2-ylamineThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Copper-catalyzed one-pot coupling reactions of aldehydes (ketones), tosylhydrazide and 2-amino(benzo)thiazoles: An efficient strategy for the synthesis of N-alkylated (benzo)thiazoles》 were Xie, Zengyang; Chen, Ruijiao; Ma, Mingfang; Kong, Lingdong; Liu, Jun; Wang, Cunde. And the article was published in Applied Organometallic Chemistry in 2019. Computed Properties of C7H5ClN2S The author mentioned the following in the article:

An efficient and practical C-N bond formation methodol. for the synthesis of N-(alkyl)benzothiazoles I [R = H, 4-Me, 6-Br, etc.; R1 = n-Pr, Ph, 4-MeOC6H4, etc.] and N-(alkyl)thiazoles II [R2 = H, Me; R3 = Ph, 2-MeC6H4, 2-naphthyl, etc.; R2R3 = (CH2)5; R4 = H, 4-Me, 5-Me] was developed via Cu-catalyzed one-pot two-step cross-coupling of 2-aminobenzothiazoles/2-aminothiazoles and aldehydes/ketones with tosylhydrazide. This cross-coupling reaction proceeded smoothly and tolerated a broad range of functional groups. A variety of functionalized benzothiazoles/thiazoles were obtained in moderate to high yields. Notably, gram-scale synthesis of fanetizole (anti-inflammatory drug) was also realized through this protocol. In the experimental materials used by the author, we found 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Computed Properties of C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Computed Properties of C7H5ClN2SThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2018,Liu, Juan-Juan; Lu, Yan-Ju; Zhao, Zhen-Dong; Xu, Shi-Chao; Bi, Liang-Wu published 《Synthesis and Cytotoxic Activity of Amides from Isopimaric Acid》.Chemistry of Natural Compounds published the findings.Name: 5-Bromothiazol-2-amine The information in the text is summarized as follows:

The amide derivatives were synthesized from isopimaric acid and characterized by spectroscopy. These amides were examined in vitro for their cytotoxic activity against four cancer cell lines. The majority of the screened compounds displayed better inhibitory activity than isopimaric acid, and many amides displayed promising cytotoxic activity against hepatocarcinoma (HepG-2), breast carcinoma (MDA-MB-231), and prostate adenocarcinoma (PC-3). The substituent type, number, and position in the benzene and heterocyclic rings have an important influence on cytotoxicity against the three tested cancer cell lines. In the experimental materials used by the author, we found 5-Bromothiazol-2-amine(cas: 3034-22-8Name: 5-Bromothiazol-2-amine)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

COA of Formula: C7H5ClN2SOn November 27, 2019 ,《Chagas Disease Drug Discovery: Multiparametric Lead Optimization against Trypanosoma cruzi in Acylaminobenzothiazole Series》 appeared in Journal of Medicinal Chemistry. The author of the article were Fleau, Charlotte; Padilla, Angel; Miguel-Siles, Juan; Quesada-Campos, Maria T.; Saiz-Nicolas, Isabel; Cotillo, Ignacio; Cantizani Perez, Juan; Tarleton, Rick L.; Marco, Maria; Courtemanche, Gilles. The article conveys some information:

Acylaminobenzothiazole hits were identified as potential inhibitors of T. cruzi replication, a parasite responsible for Chagas Disease. We selected compound 1, N-(6-chlorobenzo[d]thiazol-2-yl)cyclopropanecarboxamide, for lead optimization, aiming to improve in parallel its anti-T. cruzi activity (IC50 = 0.630μM) and its human metabolic stability (human clearance = 9.57mL/min/g). A total of 39 analogs of 1 were synthesized and tested in vitro. We established a multiparametric structure activity relationship, allowing optimization of both anti-parasite activity, physicochem. parameters and ADME properties. We identified compound 50, N-(5-Fluoro-6-(trifluoromethyl)benzothiazol-2-yl)cyclopropanecarboxamide, as an advanced lead with an improved anti-T. cruzi activity in vitro (IC50 = 0.079μM), an enhanced metabolic stability (Human Clearance = 0.413mL/min/g) and opportunity for oral route of administration. After tolerability assessment, compound 50 demonstrated a promising in vivo efficacy. In the experiment, the researchers used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gong, Xiaobei; Luo, Hao; Wu, Xing; Liu, Hao; Sun, Chengwu; Chen, Shicheng published an article in Indian Journal of Microbiology. The title of the article was 《Production of Red Pigments by a Newly Isolated Talaromyces aurantiacus Strain with LED Stimulation for Screen Printing》.Related Products of 30931-67-0 The author mentioned the following in the article:

Microbial pigments have been widely applied to printing in food, textile, and paper industries as a sustainable alternative to synthetic dyes. Herein, we isolated a novel Talaromyces aurantiacus strain with a strong ability to produce red pigments. We further studied pigment production conditions, stability, screen printing application, and bioactivities. Our results showed that sucrose was a favorable carbon source and the addition of L-histidine significantly enhanced the production of red pigments. Pigment production was strictly photo-regulated with effective wavelengths around 450 nm (blue light). We mixed the red pigments with cellulosic materials and explored their application potentials for screen printing on paper, cotton fabrics, and polymeric carriers. The printing d. was significantly improved from 0.3 to 0.7 by overlay printing. T. aurantiacus pigments could be stably stored at pH 5-11, temperature – 10 to 70°C, and redox potential – 200 to 300 mV. Moreover, the stable ranges were extended to pH 1-11 and temperature over 100°C after screen-printed on paper. The red pigments exhibited antioxidant activity toward 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulfonate) (IC50 10.4 mg L-1 in solution). Our results further indicated the red pigments by T. aurantiacus was environmentally friendly based on acetylcholinesterase activity assay. In addition to this study using ABTS Diammonium, there are many other studies that have used ABTS Diammonium(cas: 30931-67-0Related Products of 30931-67-0) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Related Products of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jing, Yingjun; Diao, Yujia; Yu, Xueqing published an article on February 28 ,2019. The article was titled 《Free radical-mediated conjugation of chitosan with tannic acid: Characterization and antioxidant capacity》, and you may find the article in Reactive & Functional Polymers.Related Products of 30931-67-0 The information in the text is summarized as follows:

Chitosan (CS) is a natural biopolymer with versatile applications. In this work, CS was functionalized with tannic acid (TA) by a free radical grafting procedure to improve its antioxidant capacity. The resulting TA-conjugated CS (TA-CS) showed a high TA equivalent content of 267.1 ± 5.4 mg TAE/g. The formation of TA-CS was verified by UV-vis, FTIR, and 1H NMR analyses. Moreover, TA-CS showed a lower thermal stability and crystallinity than CS and exhibited a good water-solubility of 15.0 ± 0.3 mg/mL. The DPPH radical scavenging activity of TA-CS reached a maximum of 91.6%, which was 6.4-fold higher than that of CS. Similar results were also observed in ABTS and hydroxyl radical scavenging assays. Moreover, TA-CS showed a higher superoxide radical scavenging activity and ferrous ion chelating activity than both TA and CS. These results suggest that conjugating with TA is an available way to enhance the antioxidant capacity of CS. In the experimental materials used by the author, we found ABTS Diammonium(cas: 30931-67-0Related Products of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Related Products of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lin, Zhi-Qi; Shao, Wei; Xu, Juan; Sheng, Guo-Ping published an article in Science of the Total Environment. The title of the article was 《Accurately quantifying the reductive capacity of microbial extracellular polymeric substance by mediated electrochemical oxidation method》.Recommanded Product: 30931-67-0 The author mentioned the following in the article:

The reductive capacity of microbial extracellular polymeric substances (EPS) plays important roles in environmental processes involved in heavy metal detoxification and organic contaminant degradation However, the crucial parameter to evaluate the reductive capacity of EPS, electron donating capacity (EDC) lacks a quant. approach. In this study, a novel mediated electrochem. oxidation (MEO) method was developed to investigate the EDCs of microbial EPS extracted from Shewanella oneidensis MR-1 (S. oneidensis MR-1), Escherichia coli (E. coli) and activated sludge. The results indicate that the MEO approach rapidly and accurately quantifies the EDCs of microbial EPS. S. oneidensis MR-1 EPS possessed the highest EDC value ascribed to their specific redox proteins components. EDCs of S. oneidensis MR-1 EPS were dependent on measurement conditions and increased with growing solution pH and applied potential. EDCs of S. oneidensis MR-1 EPS were depleted gradually during the redox reaction with irreversible oxidation of EPS. The reductive property of microbial EPS was accurately evaluated by quantifying the EDCs of EPS using the MEO approach, as well as their potential in environmental remediation.ABTS Diammonium(cas: 30931-67-0Recommanded Product: 30931-67-0) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Maliyappa, M. R.; Keshavayya, J.; Mahanthappa, Mallappa; Shivaraj, Y.; Basavarajappa, K. V. published an article on January 5 ,2020. The article was titled 《6-Substituted benzothiazole based dispersed azo dyes having pyrazole moiety: Synthesis, characterization, electrochemical and DFT studies》, and you may find the article in Journal of Molecular Structure.Computed Properties of C7H5ClN2S The information in the text is summarized as follows:

In the present work discusses synthesis, structural characterization and electrochem. investigation on some azo dyes derived from substituted benzothiazoles. The conventional diazo-coupling method was adopted to afford the heterocyclic azo dyes of benzothiazoles having pyrazole moiety. The obtained azo dyes were characterized by FT-IR, UV-visible, fluorescence, 1HNMR and, mass spectrometric techniques. The quantum chem. studies (DFT) was also used to interpret the structural properties of the compounds by using B3LYP program at 6-311++ (d, p) basis set. Further, the cyclic voltammetry was used to study the electrochem. behavior of the synthesized azo dyes in 0.1 M H2SO4 solution on a glassy carbon electrode at different scan rates. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Computed Properties of C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Computed Properties of C7H5ClN2SThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica