Author: tianli

In 2013,Suzuki, Kenji; Hamada, Yoshio; Nguyen, Jeffrey-Tri; Kiso, Yoshiaki published 《Novel BACE1 inhibitors with a non-acidic heterocycle at the P1′ position》.Bioorganic & Medicinal Chemistry published the findings.Name: 5-Bromothiazol-2-amine The information in the text is summarized as follows:

We have reported potent peptidic and non-peptidic BACE1 inhibitors with a hydroxymethylcarbonyl (HMC) isostere as a substrate transition-state mimic. However, our potent inhibitors possess a tetrazole ring at the P1′ position. It is desirable that central nervous system (CNS) drugs do not possess an acidic moiety. In this study, we synthesized non-acidic BACE1 inhibitors with heterocyclic derivatives at the P1′ position. KMI-1764 I exhibited potent inhibitory activity (IC50 = 27 nM). Interestingly, these non-acidic inhibitors tended to follow the quant. structure-activity relationship (QSAR) equation and interacted with BACE1-Arg235 in the binding model. The experimental process involved the reaction of 5-Bromothiazol-2-amine(cas: 3034-22-8Name: 5-Bromothiazol-2-amine)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Name: 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Ferrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity》 was written by Jakopec, Silvio; Pantalon Juraj, Natalija; Brozovic, Anamaria; Jadresko, Dijana; Peric, Berislav; Kirin, Srecko I.; Raic-Malic, Silvana. HPLC of Formula: 95-24-9 And the article was included in Applied Organometallic Chemistry on April 30 ,2022. The article conveys some information:

Ferrocene derivatives with mono- Py2NCH2Trz-1-R (8a-c; Py = 2-pyridyl, Trz = 1,2,3-triazol-5-yl; R = Fc, FcCH2, FcCHMe) and bis-1,2,3-triazolyl fc(CH2-1-TrzCH2NPy2)2(9, fc = 1,1′-ferrocenediyl) and ArN(CH2Trz-1-R)2 (10a-13c; R = Fc, FcCH2, FcCHMe; Ar = Ph, 2-benzothiazolyl, 6-chloro-2-benzothiazolyl, 6-nitro-2-benzothiazolyl) chelating groups were synthesized by regioselective copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes with ferrocene azides. Metal complexes of the ligands were prepared with Cu(II) and Zn(II) salts. Crystal structures of ligands 9 and 11a were determined, as well as the structures of complexes [Cu(8a)2](CF3SO3)2 (8a-Cu) and [Cu(8c)2(MeOH)2](BF4)2 (8c-Cu). In addition to NMR and UV-Vis spectroscopy, the metal complexes were characterized by cyclic voltammetry. The cytotoxic effect of ferrocene conjugates and their Zn(II) and Cu(II) complexes was explored, and cell cycle anal. was performed. The complex [Cu(8c)2](CF3SO3)2 showed the most prominent and selective cytotoxicity on cervical carcinoma (HeLa), ovarian cancer (MES-OV), non-small cell lung cancer (A549) and breast carcinoma (MDA-MB-231) cells. This complex increased cell population in the S and G2/M phase of the cell cycle, which was accompanied by an increase of the cells present in the sub-G0/G1 fraction. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Allylation of 2-Aminothiazoles with Terminal Allenes》 was published in European Journal of Organic Chemistry in 2019. These research results belong to Zheng, Jun; Woerl, Benjamin; Breit, Bernhard. Recommanded Product: 95-24-9 The article mentions the following:

A rhodium-catalyzed chemo-, regio- and enantioselective intermol. coupling reaction of 2-aminobenzothiazoles with terminal allenes is reported. The new reaction displays a wide substrate scope for both reaction partners to deliver the allylation products in good yields, with excellent regio- and enantioselectivity. This novel methodol. was further applied in an efficient synthesis of chiral isothiourea. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Recommanded Product: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Recommanded Product: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Quality Control of ABTS DiammoniumOn November 30, 2021 ,《Effect of ultrasound on mass transfer kinetics and phenolic compounds of apple cubes during osmotic dehydration》 appeared in LWT–Food Science and Technology. The author of the article were Ma, Youchuan; Yi, Jianyong; Bi, Jinfeng; Zhao, Yuanyuan; Li, Xuan; Wu, Xinye; Du, Qianqian. The article conveys some information:

This study investigated the impacts of ultrasound-assisted osmotic dehydration (UOD) with different frequency (40 kHz, 80 kHz, 40 + 80 kHz) and intensity (25 W/L, 50 W/L, 75 W/L) on the kinetics of mass transfer, phenolic losses and the antioxidant properties of apple cubes (8 mm). The mass transfer efficiency of solid gain (SG) was greater under dual-frequency (β = 0.413) than 40 kHz (β = 0.707) and 80 kHz (β = 0.793) under the same intensity. Moreover, the mass transfer efficiency of SG under 75 W/L 40 kHz UOD was higher than that of 25 W/L and 50 W/L UOD based on β values. Notably, the loss of phenolic content under 75 W/L UOD (18.9%) was substantially higher than that of the 25 W/L UOD treatment (1.2-1.8%). A UOD treatment of 50 W/L and 40 + 80 kHz is recommended to optimize mass transfer efficiency and phenolic retention of dehydrated apple cubes.ABTS Diammonium(cas: 30931-67-0Quality Control of ABTS Diammonium) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Quality Control of ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

SDS of cas: 95-24-9On March 1, 2019, Nagaraju, Burri; Kovvuri, Jeshma; Kumar, C. Ganesh; Routhu, Sunitha Rani; Shareef, Adil Md.; Kadagathur, Manasa; Adiyala, Praveen Reddy; Alavala, Sateesh; Nagesh, Narayana; Kamal, Ahmed published an article in Bioorganic & Medicinal Chemistry. The article was 《Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability》. The article mentions the following:

A series of new pyrazole linked benzothiazole-β-naphthol derivatives were designed and synthesized using a simple, efficient and ecofriendly route under catalyst-free conditions in good to excellent yields. These derivatives were evaluated for their cytotoxicity on selected human cancer cell lines. Among those, the derivatives 4j, 4k and 4l exhibited considerable cytotoxicity with IC50 values ranging between 4.63 and 5.54 μM against human cervical cancer cells (HeLa). Structure activity relationship was elucidated by varying different substituents on benzothiazoles and pyrazoles. Further, flow cytometric anal. revealed that these derivatives induced cell cycle arrest in G2/M phase and spectroscopic studies such as UV-visible, fluorescence and CD studies showed that these derivatives exhibited good DNA binding affinity. Addnl., these derivatives can effectively inhibit the topoisomerase I activity. Viscosity studies and mol. docking studies demonstrated that the derivatives bind with the minor groove of the DNA. In the experimental materials used by the author, we found 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9SDS of cas: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.SDS of cas: 95-24-9The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Safety of 6-Chlorobenzothiazol-2-ylamineOn May 15, 2019 ,《Design, synthesis, biological evaluation and computational study of novel triazolo[4,3-a]pyrazine analogues》 appeared in Journal of Molecular Structure. The author of the article were Jethava, Divya J.; Acharya, Prachi T.; Vasava, Mahesh S.; Bhoi, Manoj N.; Bhavsar, Zeel A.; Rathwa, Sanjay K.; Rajani, Dhanji P.; Patel, Hitesh D.. The article conveys some information:

In search of suitable potent drug candidate, the design, synthesis, characterization, biol. activities and computation study of novel triazolo[4,3-a]pyrazine analogs was reported. The newly synthesized compounds were evaluated for their in vitro biol. activities such as anti-malarial, anti-tuberculosis, anti-bacterial and anti-fungal activities against plasmodium falciparum, H37Rv, various bacterial and fungal strains, resp. The mol. docking study was carried out with enzyme aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum to analyze their binding orientation in the active site of the aspartic proteinase enzyme. The best docking complex was subjected to mol. dynamics simulation to illustrate the stability of these complexes and the most prominent interactions during the simulated trajectory. ADMET properties of all the synthesized compounds to predict the pharmacokinetic properties for the selection of the active and bioavailability of compounds has been calculated In the experimental materials used by the author, we found 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Safety of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Safety of 6-Chlorobenzothiazol-2-ylamineThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2018,Turkish Journal of Chemistry included an article by Kayagil, Ismail; Mutlu, Ayse Guel; Bayhan, Ulkue; Yilmaz, Inanc; Demirayak, Seref. Electric Literature of C10H8N2O2S. The article was titled 《Synthesis and characterizations of novel thiazolyl-thiadiazole derivatives as telomerase activators》. The information in the text is summarized as follows:

Pyridine-3/4-thiocarboxamide derivatives were used as starting materials for the synthesis of the target compounds The pyridine-3/4-thiocarboxamide derivatives were reacted with Et 2-chloroacetoacetate in ethanol to give the thiazole derivatives The two Et thiazole-carboxylate derivatives thus obtained were treated with sodium hydroxide solution and ethanol and converted to carboxylic acids. The carboxylic acid derivatives were reacted with thiosemicarbazide in phosphoroxy trichloride and aminothiadiazole rings (5, 6) were formed. Thus, two thiazolyl-thiadiazole amine derivatives were obtained. These two derivatives were converted into two chloroacetamidothiadiazole derivatives by reaction with chloroacetylchloride over the amino group in the presence of triethylamine in acetone. After all these steps, the starting materials needed to reach the target compounds were obtained. With the two derivatives obtained in this last step, phenol and thiophenol derivatives were reacted in acetone in the presence of potassium carbonate. The target compounds, thiazolyl-thiadiazole derivatives (TDA1-6) , are completely unique and their structure has been elucidated by elemental anal., IR, NMR, and MS spectral data. After all these synthesis steps, telomerase activity studies were performed on the target compounds obtained. For this purpose, a PCR ELISA-based TRAP method was used on the heart of zebrafish. According to the enzyme assay results, derivative TDA8 has shown an increase of telomerase enzyme activity. After reading the article, we found that the author used 4-Methyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(cas: 144060-98-0Electric Literature of C10H8N2O2S)

4-Methyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(cas: 144060-98-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Electric Literature of C10H8N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mechri, Sondes; Jaballi, Imen; Ben Taheur, Fadia; Jabeur, Fadoua; Elloumi, Jihen; Bejar, Wacim; Mansour, Chalbia; Hajji, Mohamed; Fetoui, Hamadi; Mzoughi, Ridha; Chaieb, Kamel; Jaouadi, Bassem published an article in Waste and Biomass Valorization. The title of the article was 《Anti-Biofilm, Antioxidant and Cytotoxic Potential of F5, a Peptide Derived from Waste Generated During the Processing of the White Shrimp, Metapenaeus monoceros (Fabricius, 1798)》.Application In Synthesis of ABTS Diammonium The author mentioned the following in the article:

In previous research works, we have described the production of 7 kDa F5 peptide after a hydrolysis of the white shrimp, Metapenaeus monoceros (Fabricius, 1798) byproduct, using a serine alk. protease (SPVP) purified from Aeribacillus pallidus strain VP3. The present study aims to explore the antioxidative potentials of F5 peptide by both in vitro and in vivo assays. The anti-biofilm activity was performed, showing 50% inhibition at 2μg/mL, 3μg/mL, 19μg/mL, and 45μg/mL for Staphylococcus aureus, Escherichia coli, Bacillus cereus, and Pseudomonas aeruginosa, resp. Consistently, the antioxidative capacity was tested in vitro against 2,2′-azino-bis-(3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS) cation radical, β-caroten-linoleic acid bleaching, chelating capacity of ferrous ion, and ferric reducing power assays. The cytotoxic effects of F5 peptide on the Human embryonic kidney HEK293 cells were subsequently tested. Remarkably, the F5 peptide was able to improve significantly HEK293 cell viability. To further assess this bioactivity, an in vivo study was performed on adult mice models. The animals were divided into three groups: controls, 100 mg and 200 mg of F5/kg per bodyweight. Indeed, the F5 peptide could prevent the lipid and protein oxidation damage in kidney cells, improving the antioxidative enzymic and non-enzymic capacities. In the experiment, the researchers used ABTS Diammonium(cas: 30931-67-0Application In Synthesis of ABTS Diammonium)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Application In Synthesis of ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ning, Qiqi; Wang, Yingying; Wang, Yilu; Tu, Fangming; Chen, Xiaodi; Chen, Qiming; Liu, Zhanmin published their research in Sensors and Actuators, B: Chemical on August 15 ,2022. The article was titled 《Development of an enhanced visual signal amplification assay for GSH detection with DNA-cleaving DNAzyme as a trigger》.Electric Literature of C18H24N6O6S4 The article contains the following contents:

Glutathione (GSH) plays a significant role in human health. Considering that dietary intake of GSH is an important way to keep GSH levels in the body, it is particularly essential to quantitate the supplemental content of GSH. In this study, an enhanced visual signal amplification assay for GSH detection in food with DNA-cleaving DNAzyme as a trigger was developed. The trigger contained a Trigger-enzyme strand (Pb2+ dependent DNAzyme sequence) and a Trigger-substrate strand. In the absence of GSH, DNAzyme was formed with Pb2+ induction and Trigger-substrate strand was cleaved to release the initiator sequence. Initiator sequence could initiate RCA reaction and generate abundant G-quadruplex sequences. After G-quadruplex/hemin DNAzyme was formed in the presence of G-quadruplex sequences, a visual signal could be produced by catalyzing ABTS. In the presence of GSH, Pb2+ would combine with GSH and there would not be following visual signal production Thus, GSH could be detected with a “”turn-off”” strategy and GSH concentration was neg. correlated with color change. Besides, Nb. BbvCI nicking endonuclease was introduced to improve the visual effect. The results could be qual. identified by the naked eye and quant. analyzed by spectrophotometry (Linearity range: 10 nM to 1 μM, LOD: 3.99 nM) with good selectivity and reliability. We also developed a smartphone-based visual anal. method to make the quant. anal. independent on a spectrophotometer (Linearity range: 10 nM to 0.5 μM, LOD: 8.17 nM). We believe that this assay showed a good potential for rapid and sensitive detection of GSH in food. The experimental process involved the reaction of ABTS Diammonium(cas: 30931-67-0Electric Literature of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Silica-Supported P2O5 as an Efficient Heterogeneous Catalyst for the One Pot Synthesis of 3-Amino-imidazo[2,1-b](1,3)benzothiazole under Green Conditions》 were Khan, Takallum; Yadav, Ritu. And the article was published in Journal of Heterocyclic Chemistry in 2019. Quality Control of 6-Chlorobenzothiazol-2-ylamine The author mentioned the following in the article:

The new approach involving the solid supported catalyst for the formation of C-N bond followed by cyclization has been reported. In this work we have reported a facile, efficient, and environment-friendly protocol for the synthesis of some new 3-amino-imidazo[2,1-b](1,3)benzothiazole derivatives by one-pot condensation of 2-aminobenzothiazole, indole-3-carbaldehyde, and aryl isocyanide in the presence of silica-supported P2O5 as a heterogeneous solid acid catalyst. The reaction was performed using conventional method under green conditions. The present approach offers the advantages of simple methodol., inexpensive acid catalyst, short reaction time, easy work up with excellent yield, simple purification and use of green solvent. All the newly synthesized compounds were characterized in details using phys. and chem. techniques such as m.p., 1H NMR, 13C NMR, and FTIR spectroscopy. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Quality Control of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Quality Control of 6-Chlorobenzothiazol-2-ylamineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica