Author: tianli

Zhang, Kaiyue; Li, Zongjin published the artcile< Molecular Imaging of Therapeutic Effect of Mesenchymal Stem Cell-Derived Exosomes for Hindlimb Ischemia Treatment>, Safety of (S)-2-(6-Hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid, the main research area is exosome mesenchymal stem cell mol imaging hindlimb ischemia; Bioluminescent imaging; Exosome; Firefly luciferase; Hindlimb ischemia; Luciferin; MSC.

Critical limb ischemia is a major cause of morbidity and mortality worldwide. Recently, many studies confirmed that MSC-derived exosomes (MSC-exosomes) had potential therapeutic effect to treat hindlimb ischemia through pro-angiogenesis. The therapeutic angiogenesis is a critical measurement to judge the beneficial effect of MSC-exosomes treatment. Formerly, the therapeutic effect of MSC-exosomes was usually evaluated through clin. assessment and histopathol. examination Here, we describe a strategy to evaluate the therapeutic effect of MSC-exosomes by monitoring the therapeutic angiogenesis with bioluminescent imaging in hindlimb ischemia mice models.

Methods in Molecular Biology (New York, NY, United States) published new progress about Angiogenesis. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Safety of (S)-2-(6-Hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Healy, Alan R.; Wernke, Kevin M.; Kim, Chung Sub; Lees, Nicholas R.; Crawford, Jason M.; Herzon, Seth B. published the artcile< Synthesis and reactivity of precolibactin 886>, COA of Formula: C12H18N2O4S, the main research area is synthesis precolibactin 886 nucleophilic cleavage.

The clb gene cluster encodes the biosynthesis of metabolites known as precolibactins and colibactins. The clb pathway is found in gut commensal Escherichia coli, and clb metabolites are thought to initiate colorectal cancer via DNA crosslinking. Here we report confirmation of the structural assignment of the complex clb product precolibactin 886 via a biomimetic synthetic pathway. We show that an α-ketoimine linear precursor undergoes spontaneous cyclization to precolibactin 886 on HPLC purification Studies of this α-ketoimine and the related α-dicarbonyl revealed that these compounds are unexpectedly susceptible to nucleophilic cleavage under mildly basic conditions. This cleavage pathway forms other known clb metabolites or biosynthetic intermediates and explains the difficulties in isolating fully mature biosynthetic products. This cleavage also accounts for a recently identified colibactin-adenine adduct. The colibactin peptidase ClbP deacylates synthetic precolibactin 886 to form a non-genotoxic pyridone, which suggests precolibactin 886 lies off the path of the major biosynthetic route.

Nature Chemistry published new progress about Biomimetic synthesis. 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, COA of Formula: C12H18N2O4S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Al-Shamkhani, Zeki A. Naser; Al-Hazam, Hanan A. published the artcile< Microwave Assisted Synthesis, Characterizations and Antibacterial Activity of Some of Thiazole Derivatives>, Quality Control of 57493-24-0, the main research area is thiazole amino preparation antibacterial microwave.

A series of substituted 2-amino thiazole compounds I (R = H, 4-OH, 2-F, etc.) were synthesized by reaction of substituted acetophenone with thiourea and iodine in microwave oven. The biol. screening data of the synthesized compounds I were also studied.

Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Quality Control of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ho, Ginny D.; Michael Seganish, W.; Bercovici, Ana; Tulshian, Deen; Greenlee, William J.; Van Rijn, Rachel; Hruza, Alan; Xiao, Li; Rindgen, Diane; Mullins, Deborra; Guzzi, Mario; Zhang, Xiaoping; Bleickardt, Carina; Hodgson, Robert published the artcile< The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia>, Quality Control of 1003-32-3, the main research area is phosphodiesterase inhibitor schizophrenia dihydroimidazoisoquinoline derivative preparation SAR.

The identification of potent and orally active dihydroimidazoisoquinolines as PDE 10A inhibitors is reported. The SAR development led to the discovery of compound 35 (I) as a potent, selective, and orally active PDE10A inhibitor. Compound 35 inhibited MK-801-induced hyperactivity at 3 mg/kg and displayed a 10-fold separation between the minimal EDs for inhibition of MK-801-induced hyperactivity and hypolocomotion in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Antipsychotics. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Quality Control of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mitiouchkina, Tatiana; Mishin, Alexander S.; Somermeyer, Louisa Gonzalez; Markina, Nadezhda M.; Chepurnyh, Tatiana V.; Guglya, Elena B.; Karataeva, Tatiana A.; Palkina, Kseniia A.; Shakhova, Ekaterina S.; Fakhranurova, Liliia I.; Chekova, Sofia V.; Tsarkova, Aleksandra S.; Golubev, Yaroslav V.; Negrebetsky, Vadim V.; Dolgushin, Sergey A.; Shalaev, Pavel V.; Shlykov, Dmitry; Melnik, Olesya A.; Shipunova, Victoria O.; Deyev, Sergey M.; Bubyrev, Andrey I.; Pushin, Alexander S.; Choob, Vladimir V.; Dolgov, Sergey V.; Kondrashov, Fyodor A.; Yampolsky, Ilia V.; Sarkisyan, Karen S. published the artcile< Plants with genetically encoded autoluminescence>, Product Details of C11H8N2O3S2, the main research area is Nicotiana leaf caffeic acid hispidin synthase signaling bioluminescence imaging.

Abstract: Autoluminescent plants engineered to express a bacterial bioluminescence gene cluster in plastids have not been widely adopted because of low light output. We engineered tobacco plants with a fungal bioluminescence system that converts caffeic acid (present in all plants) into luciferin and report self-sustained luminescence that is visible to the naked eye. Our findings could underpin development of a suite of imaging tools for plants.

Nature Biotechnology published new progress about Bioluminescent imaging. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Product Details of C11H8N2O3S2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Rezania, Jafar; Behzadi, Hadi; Shockravi, Abbas; Ehsani, Morteza; Akbarzadeh, Elahe published the artcile< Synthesis and DFT calculations of some 2-aminothiazoles>, Name: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is aminothiazole preparation green chem DFT calculation; ketone aryl thiourea cyclization iodine catalyst.

A series of 2-aminothiazole derivatives I (R = C6H5, 3-pyridyl, 3-O2NC6H4, etc.) has been synthesized by the reaction of acetyl compounds RC(O)CH3 with thiourea and iodine as catalyst under solvent-free condition, a green chem. method. The quantum chem. calculations at the DFT/B3LYP level of theory in gas phase were carried out for starting acetyl derivatives The HOMO and LUMO and related reactivity descriptor of acetyl derivatives, as well as, enthalpy of reactions are calculated in order to investigate the reaction properties of acetyl compounds and yields of the reactions. The calculated reactivity descriptors are well correlated to activity of different acetyl derivatives

Journal of Molecular Structure published new progress about Alkyl aryl ketones Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Name: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Uppal, Archana; Kothiyal, Preeti; Singh, Anita published the artcile< Hybrid Class Phenylthiazole and 1,2,3,4-Tetrahydronaphthalene Target Sertraline Transporter for Antidepressant Action Revealed by Molecular Docking Studies>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is phenylthiazolyltetrahydronaphthalene derivative preparation antidepressant activity; epoxytetrahydronaphthalene preparation amine addition.

Phenylthiazolyl-substituted 1,2,3,4-tetrahydronaphthalene derivatives e. g., I, were synthesized, and their chem. structures were elucidated by Fourier transform IR, 1H-NMR, 13C-NMR spectral data and elemental analyses. Antidepressant-like activities of these compounds were screened using both Porsolt’s behavioral despair on albino mice and tail suspension tests. Open field test was also performed for the examination of probable neurol. deficits, which may interfere with the test results. The test compounds exhibited different levels of antidepressant activities. Addnl., the key ligand was further substantiated by docking experiment to explore plausible mode of binding in mol. dynamics overflow. The studies elucidates role of a hydrophilic H-bonding region and pi-cation binding as a major driving force for biol. activity.

Journal of Heterocyclic Chemistry published new progress about Addition reaction. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jiang, Xingyu; Beiger, Jason J.; Hartwig, John F. published the artcile< Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis>, HPLC of Formula: 1003-32-3, the main research area is stereodivergent allylic substitution iridium Lewis base; chiral allyl arylacetic ester preparation mol crystal structure; iridium Lewis base stereodivergent allylic substitution synergistic catalyst.

The preparation of all possible stereoisomers of a given chiral mol. bearing multiple stereocenters by a simple and unified method is a significant challenge in asym. catalysis. We report stereodivergent allylic substitutions with aryl acetic acid esters catalyzed synergistically by a metallacyclic iridium complex and benzotetramisole. Through permutations of the enantiomers of the two chiral catalysts, all four stereoisomers of the products bearing two adjacent stereocenters, e.g., I, are accessible with high diastereoselectivity and enantioselectivity. The resulting chiral activated ester products can be converted readily to enantioenriched amides, unactivated esters, and carboxylic acids in a one-pot manner.

Journal of the American Chemical Society published new progress about Allylic substitution reaction (stereoselective). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, HPLC of Formula: 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ogawa, Haruhisa; Ono, Ryohei; Noguchi, Yoshifumi; Kitada, Nobuo; Saito-Moriya, Ryohei; Maki, Shojiro A.; Akiyama, Hidefumi; Itabashi, Hideyuki; Hiyama, Miyabi published the artcile< Absorption Spectra for Firefly Bioluminescence Substrate Analog: TokeOni in Various pH Solutions>, Reference of 2591-17-5, the main research area is AkaLumine TokeOni protonation dissociation constant UV spectrum.

AkaLumine hydrochloride, named TokeOni, is one of the firefly luciferin analogs, and its reaction with firefly luciferase produces near-IR (NIR) bioluminescence. Prior to studying the bioluminescence mechanism, basic knowledge about the chem. structures, electronic states, and absorption properties of TokeOni at various pH values of solution has to be acquired. In this paper, the absorption spectra for TokeOni and AkaLumine at pH 2-10 were measured. D. functional theory (DFT) calculations, time-dependent DFT calculations, and the vibrational analyses were carried out. The absorption spectra indicate that the chem. forms of TokeOni in solutions are same as those of AkaLumine. The peaks at pH 7-10 in the absorption spectra correspond to the excitation from the ground state of a carboxylate anion of AkaLumine, the peak at pH 2 corresponds to the excitation from the ground state of a carboxylate anion with an N-protonated thiazoline ring and N-protonated dimethylamino group of AkaLumine, and the peak at pH 4 corresponds to the excitation from the ground state of a carboxylate anion with an N-protonated thiazoline ring of AkaLumine.

Photochemistry and Photobiology published new progress about Bioluminescence. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Reference of 2591-17-5.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kikelj, D.; Urleb, U. published the artcile< Product class 17: thiazoles>, Application of C4H3NOS, the main research area is review thiazole preparation.

A review of synthetic methods to prepare thiazoles as well as reactive modifications of thiazole moieties.

Science of Synthesis published new progress about Cyclization. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Application of C4H3NOS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica