Author: tianli

Sillero, Leyre; Prado, Raquel; Welton, Tom; Labidi, Jalel published their research in Sustainable Chemistry and Pharmacy on December 31 ,2021. The article was titled 《Extraction of flavonoid compounds from bark using sustainable deep eutectic solvents》.Application of 30931-67-0 The article contains the following contents:

The use of green solvents in extraction processes, especially for applications of lignocellulosic biomass, has been extensively studied over the last years. Among the range of different green solvents, deep eutectic solvents (DES) show promising results for extraction processes. Therefore, the aim of this work was the use of DES as additives in aqueous mixtures for the selective extraction of flavonoid compounds from the bark of Larix decidua. For this purpose, bark has been treated using different solvent ratios consisting of a DES/H2O mixture (0, 25, 50 and 75 wt%). Two DES were studied, choline chloride:urea and choline chloride:1,4-butanediol. In order to study the success of the extractions, the extracts and the remaining solid fraction were characterized. From the results, it was concluded that the choline chloride:1,4-butanediol (75 wt%) gave the best results, obtaining the richest extracts in flavonoids (383 mg CE/g dried bark extract), as well as those with the highest antioxidant capacity. These good results confirm the capacity of this DES to obtain active biomols. for further application. In the experiment, the researchers used many compounds, for example, ABTS Diammonium(cas: 30931-67-0Application of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2004,Quelever, Gilles; Burlet, Stephane; Garino, Cedrik; Pietrancosta, Nicolas; Laras, Younes; Kraus, Jean-Louis published 《Simple Coupling Reaction between Amino Acids and Weakly Nucleophilic Heteroaromatic Amines》.Journal of Combinatorial Chemistry published the findings.HPLC of Formula: 3034-22-8 The information in the text is summarized as follows:

Solution-phase amidation of amino acid Boc-Ala-OH by substituted, weakly nucleophilic heterocyclic aromatic amines was studied in presence of coupling reagents using a parallel synthesis procedure. Coupling agents POCl3/pyridine, BOP, DCC/HOBt, and HBTU were examined for this reaction. Thus, Boc-Ala-NHAr [Ar = CH2C6H4NO2-4, CH2Ph, CH2C6H11, 4-(4-nitrophenyl)-2-thiazolyl, 5-bromo-2-thiazolyl, 2-thiazolyl, 5-nitro-2-thiazolyl] were prepared in moderate to high yields. The results showed that when bulky, weakly nucleophilic, heterocyclic aromatic amines are to be coupled, POCl3 in pyridine could be used as a coupling agent in solution-phase automated synthesis for obtaining racemization-free products in reasonable good yields. In the experiment, the researchers used many compounds, for example, 5-Bromothiazol-2-amine(cas: 3034-22-8HPLC of Formula: 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 3034-22-8In 2017 ,《In vitro studies on the inhibition of colon cancer by amino acid derivatives of bromothiazole》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Vale, Nuno; Correia-Branco, Ana; Patricio, Barbara; Duarte, Diana; Martel, Fatima. The article contains the following contents:

The investment in cancer research is critical to find more and better treatments, but essentially to save lives. This paper describes the synthesis and characterization of bromothiazole derivatives with amino acids, e.g., I, and with core of nitazoxanide, an FDA-approved antiprotozoal drug. Using a human adenocarcinoma-derived cell line (the Caco-2 cell line), the antiproliferative (3H-thymidine incorporation) and cytotoxic (extracellular lactate dehydrogenase activity) effect of these derivatives, were investigated. All the derivatives caused a concentration-dependent decrease in cell proliferation and viability. At their highest concentration, all compounds were able to reduce 3H-thymidine incorporation by more than 80%, corresponding to a more marked antiproliferative effect than butyrate. As to their cytotoxic effect, it was comparable to that of butyrate. The ability of bromo substituent in thiazole ring with sequences of amino acids in inducing cell death and apoptosis in Caco-2 cells (and other cell lines) is now being studied. The experimental part of the paper was very detailed, including the reaction process of 5-Bromothiazol-2-amine(cas: 3034-22-8Application of 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Application of 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

SDS of cas: 3034-22-8In 2011 ,《Synthesis and application of a new thiazolylazo reagent for cloud point extraction and determination of cobalt in pharmaceutical preparations》 was published in Journal of AOAC International. The article was written by Yamaki, Regina Terumi; Nunes, Luana Sena; Rodrigues de Oliveira, Hygor; Araujo, Andre S.; Bezerra, Marcos Almeida; Lemos, Valfredo Azevedo. The article contains the following contents:

The synthesis and characterization of the reagent 2-(5-bromothiazolylazo)-4-chlorophenol (I) and its application in the development of a preconcentration procedure for cobalt determination using flame at. absorption spectrometry after cloud point extraction is presented. This procedure is based on cobalt complexing and entrapment of the metal chelates into micelles of a surfactant-rich phase of Triton X-114. The preconcentration procedure was optimized by using a response surface methodol. through the application of the Box-Behnken matrix. Under optimum conditions, the procedure determined the presence of cobalt with an LOD of 2.8 μg/L and LOQ of 9.3 μg/L. The enrichment factor obtained was 25. The precision was evaluated as the RSD, which was 5.5% for 10 μg/L cobalt and 6.9% for 30 μg/L. The accuracy of the procedure was assessed by comparing the results with those found using inductively coupled plasma-optical emission spectrometry. After validation, the procedure was applied to the determination of cobalt in pharmaceutical preparation samples containing cobalamin (vitamin B12). After reading the article, we found that the author used 5-Bromothiazol-2-amine(cas: 3034-22-8SDS of cas: 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.SDS of cas: 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 2-Bromo-6-fluorobenzothiazoleOn October 9, 2003 ,《Design and synthesis of pyrrolidine-5,5′-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability》 was published in Journal of Medicinal Chemistry. The article was written by Borthwick, Alan D.; Davies, Dave E.; Ertl, Peter F.; Exall, Anne M.; Haley, Terry M.; Hart, Graham J.; Jackson, Deborah L.; Parry, Nigel R.; Patikis, Angela; Trivedi, Naimisha; Weingarten, Gordon G.; Woolven, James M.. The article contains the following contents:

A series of chiral, (S)-proline-α-methylpyrrolidine-5,5-trans-lactam serine protease inhibitors has been developed as antivirals of human cytomegalovirus (HCMV). The SAR of the functionality on the proline nitrogen has shown that derivatives of para-substituted Ph ureas > para-substituted Ph sulfonamides > para-substituted Ph carboxamide for activity against HCMV δAla protease, producing para-substituted Ph ureas with single figure nM potency (Ki) against the viral enzyme. The SAR of the functionality on the lactam nitrogen has defined the steric and electronic requirements for high human plasma stability while retaining good activity against HCMV protease. The combination of high potency against HCMV δAla protease and high human plasma stability has produced compounds with significant in vitro antiviral activity against human cytomegalovirus with the 6-hydroxymethyl benzothiazole derivative 72 being equivalent in potency to ganciclovir. The parent benzothiazole 56 had good pharmacokinetics in dogs with 29% bioavailability and good brain and ocular penetration in guinea pigs. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-6-fluorobenzothiazole(cas: 152937-04-7Reference of 2-Bromo-6-fluorobenzothiazole)

2-Bromo-6-fluorobenzothiazole(cas: 152937-04-7) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Reference of 2-Bromo-6-fluorobenzothiazoleTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Recommanded Product: ABTS DiammoniumOn March 4, 2020, Gaikwad, Adwait; Hlushko, Hanna; Karimineghlani, Parvin; Selin, Victor; Sukhishvili, Svetlana A. published an article in ACS Applied Materials & Interfaces. The article was 《Hydrogen-Bonded, Mechanically Strong Nanofibers with Tunable Antioxidant Activity》. The article mentions the following:

We report on mech. strong, water-insoluble hydrogen-bonded nanofiber mats composed of a hydrophilic polymer and a natural polyphenol that exhibit prolonged antioxidant activity. The high performance of fibrous mats resulted from the formation of a network of hydrogen bonds between a low-mol.-weight polyphenol (tannic acid, TA) and a water-soluble polymer (polyvinylpyrrolidone, PVP) and could be precisely controlled by the TA-to-PVP ratio. Dramatic enhancement (5- to 10-fold) in tensile strength, toughness, and Young’s moduli of the PVP/TA fiber mats (as compared to those of pristine PVP fibers) was achieved at the maximum d. of hydrogen bonds, which occurred at ∼0.2-0.4 M fractions of TA. The formation of hydrogen bonds was confirmed by an increase in the glass-transition temperature of the polymer after binding with TA. When exposed to water, the fibers exhibited composition- and pH-dependent stabilities, with the TA-enriched fibers fully preserving their integrity in acidic and neutral media. Importantly, the fiber mats exhibited strong antioxidant activity with dual (burst and prolonged) activity profiles, which could be controlled via fiber composition, a feature useful for controlling radical-scavenging rates in environmental and biol. applications. In addition to this study using ABTS Diammonium, there are many other studies that have used ABTS Diammonium(cas: 30931-67-0Recommanded Product: ABTS Diammonium) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 6-Morpholinobenzo[d]thiazol-2-amineOn October 30, 2014 ,《Design, synthesis, and structure-activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents》 was published in European Journal of Medicinal Chemistry. The article was written by Ma, Junjie; Chen, Dong; Lu, Kuan; Wang, Lihui; Han, Xiaoqi; Zhao, Yanfang; Gong, Ping. The article contains the following contents:

A series of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety were designed and synthesized and their cytotoxic activities against five cancer cell lines (NCI-H226, SK-N-SH, HT29, MKN45, and MDA-MB-231) were screened in vitro. Most of them showed moderate to excellent activity against all the tested cell lines. Two compounds (procaspase-3 EC50 = 1.42 μM and procaspase-3 EC50 = 0.25 μM) exhibited excellent antitumor activity with IC50 values ranging from 0.14 μM to 0.98 μM against all cancer cell lines, which were 1.8-8.7 times more active than the first procaspase activating compound (PAC-1) (procaspase-3 EC50 = 4.08 μM). The structure-activity relationship analyses indicated that the introduction of a lipophilic group (a benzyloxy or heteroaryloxy group) at the 4-position of the 2-hydroxyphenyl ring was beneficial to antitumor activity, and the presence of substituents containing nitrogen that are pos. charged at physiol. pH could also improve antitumor activity. It was also confirmed that the steric effect of the 4-position substituent of the benzyloxy group had a significant influence on cytotoxic activity.6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2Reference of 6-Morpholinobenzo[d]thiazol-2-amine) was used in this study.

6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Reference of 6-Morpholinobenzo[d]thiazol-2-amineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Recommanded Product: 95-24-9On March 15, 2021, Al-Janabi, Ahmed S. M.; Elzupir, Amin O.; Yousef, Tarek A. published an article in Journal of Molecular Structure. The article was 《Synthesis, anti-bacterial evaluation, DFT study and molecular docking as a potential 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2 inhibitors of a novel Schiff bases》. The article mentions the following:

New Schiff bases (L1H) I (I), (L2H) II (II), (L3H) III (III) were synthesized by reaction of 2-benzoylpyridine with different amines (2-amino-6-chlorobenzothiazole, isonicotinohydrazide and N1-(naphthalen-1-yl)ethane-1,2-diamine) and characterized by 1H-NMR, 13C-NMR, IR mass spectroscopy and elemental anal. The compounds (I), (II) and (III) were assayed by the disk diffusion method for anti-bacterial against five pathogenic bacteria species (Staphylococcus aureus, Micrococcus luteus, Staphylococcus pyogenes, Bacillus subtilis, and E. coli). All prepared Schiff bases (I), (II) and (III) showed good activity compared to pos. control (streptomycin). Moreover the L3H showed the highest activity against S. aureus, and M. luteus than the other compounds and streptomycin. In addnl. mol. docking studies with 3-chymotrypsin-like protease (3CLpro), the essential enzyme for SARS-CoV-2 proliferation. The rest of compounds have shown promising results as 3CLpro inhibitors interacting with the active sites of the enzymes. Finally, DFT’s estimated electrostatic mol. potential results were used to illustrate the mol. docking findings. The DFT calculations showed that L3H has the highest dipole moment and electrophilicity index. Interestingly, L2H of the largest energy gap ΔE = 2.49 eV, there are several hydrophilic interactions that could facilitate the binding with the receptors. All of these parameters could be shared to significantly affect the protein sites of binding affinity with different extent. In the experiment, the researchers used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Recommanded Product: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Recommanded Product: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Agarwal, Charu; Hofmann, Tamas; Pasztory, Zoltan published their research in Chemical Engineering and Processing on February 28 ,2021. The article was titled 《Low-frequency, green sonoextraction of antioxidants from tree barks of Hungarian woodlands for potential food applications》.Reference of ABTS Diammonium The article contains the following contents:

The present work evaluates and compares the antioxidant capacities of bioactive constituents in the barks of ten common wood species from Hungary (Quercus rubra, Prunus serotina, Quercus robur, Betula pendula, Fraxinus excelsior, Robinia pseudoacacia, Carpinus betulus, Picea abies, Alnus glutinosa, Pinus sylvestris). Low-frequency ultrasound was used for intensification of extraction from the bark to obtain extracts rich in polyphenolic antioxidants with potential applications in the food industry. The extractions were carried out in different aqueous organic solvents- ethanol 80% and acetone 80% at optimized conditions. The overall antioxidant capacity of the extracts was estimated by the combined evaluation of Folin-Ciocalteu total phenol content (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric reducing ability of plasma (FRAP) assays using a scoring system. Aqueous ethanol had better extraction efficiency than aqueous acetone as a solvent medium. Of all the investigated species, Quercus robur showed the maximum antioxidant capacity with TPC of 105.88 ± 17.75 mg GAE/g dw, DPPH (IC50) of 1.90 ± 0.10μg/mL, ABTS of 437.09 ± 36.22 mg TE/g dw and FRAP of 102.62 ± 8.69 mg AAE/g dw. The polyphenolic characterization of Quercus robur, Robinia pseudoacacia and Fraxinus excelsior was done by liquid chromatog./tandem mass spectrometry. In the part of experimental materials, we found many familiar compounds, such as ABTS Diammonium(cas: 30931-67-0Reference of ABTS Diammonium)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Reference of ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2019,SAR and QSAR in Environmental Research included an article by Geronikaki, A.; Petrou, A.; Kartsev, V.; Eleftheriou, P.; Boga, R.; Bartolo, B.; Crespan, E.; Franco, G.; Maga, G.. Quality Control of 6-Chlorobenzothiazol-2-ylamine. The article was titled 《Molecular docking, design, synthesis and biological evaluation of novel 2,3-aryl-thiazolidin-4-ones as potent NNRTIs》. The information in the text is summarized as follows:

A series of thiazolidinone derivatives I [R1 = 6-Cl, 6-cyano, 6-(adamant-1-yl), 6-CF3, 4-Me-6-(adamant-1-yl), R2 = 4-F, 4-NO2, 2-F-6-Cl, 2,6-Cl2, 2,6-F2] and II [R3 = 4-(pyridin-2-yl)thiazol-2-yl, 5-ethyl-4-methylthiazol-2-yl] was designed based on a butterfly mimicking scaffold consisting of a substituted benzothiazolyl moiety connected with a substituted Ph ring via a thiazolidinone moiety. The most promising derivatives were selected using mol. docking anal. and PASS prediction program, synthesized and evaluated for HIV-1 RT inhibition. Five out of fifteen tested compounds exhibited good inhibitory action. It was observed that the presence of Cl or CN substituents at position 6 of the benzothiazole ring in combination with two fluoro atoms at the ortho-positions or a hydrogen acceptor substituent at the 4-position of the Ph ring were favorable for the HIV RT inhibitory activity. In addition to this study using 6-Chlorobenzothiazol-2-ylamine, there are many other studies that have used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Quality Control of 6-Chlorobenzothiazol-2-ylamine) was used in this study.

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Quality Control of 6-Chlorobenzothiazol-2-ylamineThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica