Author: tianli

In 2011,Hebeisen, Paul; Haap, Wolfgang; Kuhn, Bernd; Mohr, Peter; Wessel, Hans Peter; Zutter, Ulrich; Kirchner, Stephan; Ruf, Armin; Benz, Joerg; Joseph, Catherine; Alvarez-Sanchez, Ruben; Gubler, Marcel; Schott, Brigitte; Benardeau, Agnes; Tozzo, Effie; Kitas, Eric published 《Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase》.Bioorganic & Medicinal Chemistry Letters published the findings.Product Details of 3034-22-8 The information in the text is summarized as follows:

A novel sulfonylureido pyridine series exemplified by compound 19 (I) yielded potent inhibitors of FBPase showing significant glucose reduction and modest glycogen lowering in the acute db/db mouse model for Type-2 diabetes. Our inhibitors occupy the allosteric binding site and also extend into the dyad interface region of tetrameric FBPase. The experimental part of the paper was very detailed, including the reaction process of 5-Bromothiazol-2-amine(cas: 3034-22-8Product Details of 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Product Details of 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Name: ABTS DiammoniumOn November 30, 2021 ,《Extraction optimization of polysaccharides from Gougunao tea and assessment of the antioxidant and hypoglycemic activities of its fractions in vitro》 appeared in Bioactive Carbohydrates and Dietary Fibre. The author of the article were Deng, Qihuan; Wang, Wenjun; Zhang, Qingfeng; Chen, Jiguang; Zhou, Huan; Meng, Wenya; Li, Jingen. The article conveys some information:

The extraction optimization, characterization, antioxidant activities and hypoglycemic in vitro of polysaccharides from Gougunao tea (GTP) were investigated in this study. The extraction conditions were optimized as extraction time of 3.2 h, solid-liquid ratio of 1:30 (g/mL) and extraction temperature of 95 °C, reaching a maximum yield of 10.78 0.21%. Three new fractions (GTP40, GTP60 and GTP80) were separated from GTP by gradient concentrations of ethanol. Their weight-average mol. weight, number-average mol. weight and polydispersity index were determined to be 48286-195451 Da, 33946-118948 Da, 1.422-1.643 by the high-performance gel permeation chromatog. (HPGPC). Chem. anal. revealed that they were all composed of arabinose, galactose, ribose, glucose, rhamnose, manose, xylose, glucuronic acid, and galacturonic acid with different molar ratios, as well as a small amount of proteins. What′s remarkable is that the antioxidant and hypoglycemic activities in vitro of them were all in the order of GTP40>GTP60>GTP80 in a concentration-dependent manner. The half inhibition concentrations (IC50) of GTP40 for 2,2-Diphenyl-1-picrylhydrazyl radical, 2,2′-Azino-bis (3-ethylbenzothiazoline- 6-sulfonic acid) radical, hydroxyl radical were 0.066 mg/mL, 0.255 mg/mL and 3.610 mg/mL, and for a-amylase and a-glucosidase were 1.271 mg/mL and 0.013 mg/mL, resp. It will provide a theor. basis for the further utilization of polysaccharides from Gougunao tea. In the experiment, the researchers used many compounds, for example, ABTS Diammonium(cas: 30931-67-0Name: ABTS Diammonium)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Name: ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Application In Synthesis of 6-Chlorobenzothiazol-2-ylamineOn May 1, 2020 ,《Discovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Huddar, Srigouri; Park, Chul Min; Kim, Hyung Jun; Jang, Soojin; Lee, Sunkyung. The article conveys some information:

New therapies for treating drug-resistant pneumococcal infections are urgently needed. The novel scaffold 6-hydroxy-4-oxo-1,2-dihydro-4H-quinoline was shown to have similar efficacies against all three different serotypes of S. pneumoniae, ATCC 49617 (19F), ATCC BAA-1663 (15B), and ATCC 700904 (19A), in a resazurin-based high-throughput screen using the Korea Chem. Bank library. Further studies to identify a new lead with this scaffold, including tricyclic pyrrolo[3,2,1-ij]quinolone and pyrido[3,2,1-ij]quinolone derivatives, led to the identification of 6d, 7d and 12a. Compound 6d (IC50 = 0.92, 0.75, and 0.77μM), 7d (IC50 = 0.57, 0.66, and 0.38μM) and 12a() (IC50 = 0.27, 1.03, and 0.62μM) showed submicromolar IC50 values against 19F, 15B, and 19A, resp., and thus serve as a starting point for further optimization. While some of compounds in this series exhibited acceptable pharmacokinetic profiles in preliminary in vivo rat experiments, the most active compound 12a showed poor solubility and high plasma protein binding. Our current research efforts are focused on optimizing compounds to improve physicochem. properties as well as potency. The results came from multiple reactions, including the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Application In Synthesis of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application In Synthesis of 6-Chlorobenzothiazol-2-ylamineThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

HajKacem, Sihem; Galai, Said; Hernandez Fernandez, Francisco Jose; Perez de los Rios, Antonia; Smaali, Issam; Quesada Medina, Joaquin published an article on January 31 ,2020. The article was titled 《Bioreactor Membranes for Laccase Immobilization Optimized by Ionic Liquids and Crosslinking Agents》, and you may find the article in Applied Biochemistry and Biotechnology.HPLC of Formula: 30931-67-0 The information in the text is summarized as follows:

A novel concept of membrane bioreactor based on polymeric ionic liquids laccase membrane has been implemented in batch process for decolorization of the anthraquinonic dye Remazol Brillant Blue R (RBBR). New laccase immobilization strategy has been optimized by casting the enzyme into a polymeric inclusion membrane (PIM) using ionic liquids (ILs) and polyvinyl chloride (PVC) leading to laccase polymeric IL membrane (PILM). Four different ILs (1-octyl-3-metylimidazolium bis(trifluoromethylsulfonyl)imide, [OMIM][NTF2]; cholinium bis(trifluoromethylsulfonyl)imide, [Ch ol][NTF2]; cholinium dihydrogenphosphate, [Chol][H2PO4] and hydroxyethylammonium formate, [HEA][Fo]) have been screened and mixed to constitute the active phase of the support of PIM. This strategy has been fully succeeded since high laccase immobilization rates were recorded (about 98%) when using the optimal mixture containing three ILs (45% [OMIM][NTf2]/5% [Chol][NTf2]/2.5% [HEA][Fo]) and supplemented by 0.5% glutaraldehyde. It was found that such mixture contributes to increase the stability and reusability of laccase-PILM during eight successive assays in a batch discontinued stirred reactor. Decolorization rate of 75% has been reached in the batch decolorization process of RBBR with high reusability yield. In the part of experimental materials, we found many familiar compounds, such as ABTS Diammonium(cas: 30931-67-0HPLC of Formula: 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.HPLC of Formula: 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Dan; Lou, Jiangfei; Xu, Jin; Yuan, Jiugang; Wang, Qiang; Wang, Ping; Fan, Xuerong published an article in Environmental Science and Pollution Research. The title of the article was 《Degradation of octylphenol polyethoxylates with a long ethoxylate chain using the laccase-mediated systems》.Reference of ABTS Diammonium The author mentioned the following in the article:

Alkylphenol polyethoxylates (APEOn) are the second-largest category of com. nonionic surfactants, which are difficult to degrade naturally in the environment. This study examined the degradation of octylphenol polyethoxylate (OPEOn) by laccase and its laccase-mediated systems. The results showed that OPEOn was poorly degraded by laccase alone. 2, 2′-azino-bis [3-ethylbenzothiazoline-6-sulfonic acid] (ABTS), 1-hydroxybenzotriazole (HBT), and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) were selected as the redox mediators. Exptl. results also indicated that 52.4% of the initial OPEOn amount was degraded by laccase in the presence of TEMPO. The degradation efficiency was analyzed using high-performance liquid chromatog. Furthermore, the structural characteristics of the degradation products were measured using matrix-assisted laser desorption/ionization-time of flight mass spectrometry and NMR spectroscopy, and it could be found that the laccase-TEMPO system could gradually shorten the ethoxylate chain by oxidizing the primary hydroxyl group of OPEOn, thereby degrading the OPEOn of the macromol. into small mols. The maximum of the ion peak distributions of OPEOn decreased from n = 8 finally down to 3. The novel enzymic system introduced by this study will become a promising alternative method for high-efficiency APEOn conversion and had great potential value in wastewater treatment. The results came from multiple reactions, including the reaction of ABTS Diammonium(cas: 30931-67-0Reference of ABTS Diammonium)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Reference of ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2006,Vulpetti, Anna; Casale, Elena; Roletto, Fulvia; Amici, Raffaella; Villa, Manuela; Pevarello, Paolo published 《Structure-based drug design to the discovery of new 2-aminothiazole CDK2 inhibitors》.Journal of Molecular Graphics & Modelling published the findings.SDS of cas: 3034-22-8 The information in the text is summarized as follows:

N-(5-Bromo-1,3-thiazol-2-yl)butanamide (compound 1) was found active (IC50 = 808 nM) in a high throughput screening (HTS) for CDK2 inhibitors. By exploiting crystal structures of several complexes between CDK2 and inhibitors and applying structure-based drug design (SBDD), we rapidly discovered a very potent and selective CDK2 inhibitor 4-[(5-isopropyl-1,3-thiazol-2-yl)amino] benzenesulfonamide (compound 4, IC50 = 20 nM). The syntheses, structure-based analog design, kinases inhibition data and x-ray crystallog. structures of CDK2/inhibitor complexes are reported. The results came from multiple reactions, including the reaction of 5-Bromothiazol-2-amine(cas: 3034-22-8SDS of cas: 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.SDS of cas: 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2016,Li, Hongshuang; Wang, Xinran; Duan, Guiyun; Xia, Chengcai; Xiao, Yuliang; Li, Furong; Ge, Yanqing; You, Guirong; Han, Junfen; Fu, Xiaopan; Tan, Shanhui; Wang, Rongwei published 《Synthesis, antitumor activity and preliminary structure-activity relationship of 2-aminothiazole derivatives》.Chemical Research in Chinese Universities published the findings.Computed Properties of C3H3BrN2S The information in the text is summarized as follows:

In this paper, we described the synthesis of 2-aminothiazole sublibrary containing Me, bromo, Ph or butylidene at 4- or/and 5-position of its core. All target compounds were evaluated for their antitumor activities against human lung cancer cell line H1299 and human glioma cell line SHG-44. Among the compounds screened, 4,5,6,7-tetrahydrobenzo[d]thiazole(26b) exhibited the most potent antitumor activities with IC50 values of 4.89 and 4.03 μmol/L against the two tested cell lines, resp. Preliminary structure-activity relationship(SAR) studies of these compound were subsequently investigated. In the experiment, the researchers used 5-Bromothiazol-2-amine(cas: 3034-22-8Computed Properties of C3H3BrN2S)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Computed Properties of C3H3BrN2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 3034-22-8In 2006 ,《Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Das, Jagabandhu; Furch, Joseph A.; Liu, Chunjian; Moquin, Robert V.; Lin, James; Spergel, Steven H.; McIntyre, Kim W.; Shuster, David J.; O’Day, Kathleen D.; Penhallow, Becky; Hung, Chen-Yi; Doweyko, Arthur M.; Kamath, Amrita; Zhang, Hongjian; Marathe, Punit; Kanner, Steven B.; Lin, Tai-An; Dodd, John H.; Barrish, Joel C.; Wityak, John. The article contains the following contents:

A series of structurally novel aminothiazole-based inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity, and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound I is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo and was previously reported to reduce lung inflammation in a mouse model of ovalbumin induced allergy/asthma. After reading the article, we found that the author used 5-Bromothiazol-2-amine(cas: 3034-22-8Related Products of 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Related Products of 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Zeolite/Chitosan/Gelatin Films: Preparation, Supercritical CO2 Processing, Characterization, and Bioactivity》 was written by Pajnik, Jelena; Dikic, Jelena; Milovanovic, Stoja; Milosevic, Milena; Jevtic, Sanja; Lukic, Ivana. Computed Properties of C18H24N6O6S4 And the article was included in Macromolecular Materials and Engineering on August 31 ,2022. The article conveys some information:

Chitosan/gelatin and chitosan/gelatin/zeolite films prepared by solvent casting method are impregnated with a mixture of thymol and carvacrol using a green solvent, supercritical carbon dioxide at 35°C and 30 MPa, during 18 h. Proposed method enables preparation of biocompatible and biodegradable blends with strong antioxidant and antibacterial activity, whereby amounts of loaded thymol/carvacrol (TC) mixture are in the range from 3.3% to 6%. After initial burst release, both types of films exhibit gradual release of bioactive compounds, with around 72% and 96% of impregnated TC mixture released in water and phosphate buffered saline solution (pH 7.4) during tested period of 10 days, resp. Results of water vapor transmission rate (>76 g m-2 day-1) confirm that prepared composites are suitable for wound dressing application. Thermal anal. shows superior properties of prepared TC loaded films compared to control samples. In addition, mech. and structural properties, as well as solubility and swelling behavior of the obtained films are investigated in detail.ABTS Diammonium(cas: 30931-67-0Computed Properties of C18H24N6O6S4) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

HPLC of Formula: 30931-67-0On October 31, 2020 ,《Enzymatic depolymerization of industrial lignins by laccase-mediator systems in 1,4-dioxane/water》 appeared in Biotechnology and Applied Biochemistry. The author of the article were Dillies, Justine; Vivien, Celine; Chevalier, Mickael; Rulence, Alexandre; Chataigne, Gabrielle; Flahaut, Christophe; Senez, Vincent; Froidevaux, Renato. The article conveys some information:

Lignin is the second most abundant polymer after cellulose in lignocellulosic biomass. Its aromatic composition and recalcitrant nature make its valorization a major challenge for obtaining low mol. weight aromatics compounds with high value-added from the enzymic depolymerization of industrial lignins. The oxidation reaction of lignin polymer using laccases alone remains inefficient. Therefore, researches are focused on the use of a laccase-mediator system (LMS) to facilitate enzymic depolymerization Until today, the LMS system was studied using water-soluble lignin only (com. lignins, modified lignins, or lignin model compounds). This work reports a study of three LMS systems to depolymerize the three major industrial lignins (organosolv lignin, Kraft lignin, and sodium lignosulfonate). We show that an enzymic depolymerization of these lignins can be achieved by LMS using laccase from Trametes versicolor, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt as mediator and a cosolvent (25% of 1,4-dioxane) to enhance the solubilization of lignins. In the part of experimental materials, we found many familiar compounds, such as ABTS Diammonium(cas: 30931-67-0HPLC of Formula: 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.HPLC of Formula: 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica