Author: tianli

Zhu, Yan-Ping; Yuan, Jing-Jing; Zhao, Qin; Lian, Mi; Gao, Qing-He; Liu, Mei-Cai; Yang, Yan; Wu, An-Xin published the artcile< I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiazole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea>, SDS of cas: 57493-24-0, the main research area is aminothiazole preparation thiourea aromatic ketone butenone cyclization.

A concise and efficient one-pot process from easily available Me ketones or unsaturated Me ketones and thiourea was developed for the synthesis of 2-aminothiazoles with I2/CuO as catalyst. The method gave the E-isomers of 4-ethenyl-2-aminothiazoles. All these target mols. were characterized by NMR, HRMS and IR spectra.

Tetrahedronpublished new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Al-Shamkhani, Zeki A. Naser; Al-Hazam, Hanan A. published the artcile< Microwave Assisted Synthesis, Characterizations and Antibacterial Activity of Some of Thiazole Derivatives>, Computed Properties of 57493-24-0, the main research area is thiazole amino preparation antibacterial microwave.

A series of substituted 2-amino thiazole compounds I (R = H, 4-OH, 2-F, etc.) were synthesized by reaction of substituted acetophenone with thiourea and iodine in microwave oven. The biol. screening data of the synthesized compounds I were also studied.

Research Journal of Pharmaceutical, Biological and Chemical Sciencespublished new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Computed Properties of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Feng, Daijun; Barton, George; Scott, Colleen N. published the artcile< Synthesis of 2,5-Dibutyl-3,6-dimethyl-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione: A Diketopyrrolopyrrole Scaffold for the Formation of Alkenyldiketopyrrolopyrrole Compounds>, Product Details of C4H3NOS, the main research area is dibutyldimethylpyrrolopyrrole dione preparation diketopyrrolopyrrole scaffold; divinyl substituted diketopyrrolopyrrole carbon hydrogen functionalization.

This manuscript describes an unprecedented and efficient synthesis of a new DPP scaffold, 2,5-dibutyl-3,6-dimethyl-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione (DMDPP), containing Me groups at the 3,6-positions as a precursor to preparing 3,6-divinyl-substituted DPP compounds Subsequently, following the synthesis of DMDPP, we performed an efficient and mild C-H functionalization of the Me groups with a variety of aromatic aldehydes to synthesize the first examples of 3,6-divinyl-substituted DPP compounds in moderate to good yields.

Organic Letterspublished new progress about Aldol condensation. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Product Details of C4H3NOS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tzani, Marina A.; Gabriel, Catherine; Lykakis, Ioannis N. published the artcile< Selective synthesis of benzimidazoles from o-phenylenediamine and aldehydes promoted by supported gold nanoparticles>, Formula: C4H3NOS, the main research area is benzimidazole preparation; phenylenediamine aldehyde gold nanoparticle supported titanium oxide catalyst; benzimidazoles; cyclization reaction; gold nanoparticles; heterogeneous catalysis; o-phenylenediamine; thiabendazole.

The catalytic efficacy of supported gold nanoparticles (AuNPs) towards the selective reaction between o-phenylenediamine and aldehydes that yielded 2-substituted benzimidazoles I [R = Ph, 4-HOC6H4, 2-furyl, etc.] was investigated. Among several supported gold nanoparticle platforms, the Au/TiO2 provided a series of 2-aryl and 2-alkyl substituted benzimidazoles at ambient conditions, in the absence of additives and in high yields, using the mixture CHCl3:MeOH in ratio 3:1 as the reaction solvent. Among the AuNPs catalysts used herein, the Au/TiO2 containing small-size nanoparticles was found to be the most active towards the present catalytic methodol. The Au/TiO2 could be recovered and reused at least five times without a significant loss of its catalytic efficacy. The present catalytic synthetic protocol applied to a broad substrate scope and represents an efficient method for the formation of a C-N bond under mild reaction conditions. Notably, this catalytic methodol. provided the regio-isomer of the anthelmintic drug, Thiabendazole, in a lab-scale showing its applicability in the efficient synthesis of such N-heterocyclic mols. at industrial levels.

Nanomaterialspublished new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Formula: C4H3NOS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ostrovskii, Vladimir S.; Beletskaya, Irina P.; Titanyuk, Igor D. published the artcile< Trifluoroacetaldehyde N-Tosylhydrazone as a Precursor of Trifluorodiazoethane in Reactions of Insertion into the Heteroatom-Hydrogen Bond>, Safety of 4,5-Dihydrothiazole-2-thiol, the main research area is trifluoroacetaldehyde tosylhydrazone trifluorodiazoethane insertion reaction copper catalyst.

Trifluorodiazoethane is a widely explored trifluoroethylating reagent, which is suitable for the preparation of a large number of fluorine-containing organic mols. Nevertheless, CF3CHN2 has some disadvantages, such as volatility, storage instability, toxicity, and explosiveness. Herein, the application of trifluoroacetaldehyde N-tosylhydrazone as a CF3CHN2 precursor capable of generating in situ trifluorodiazoethane under mild basic conditions is reported. Copper-catalyzed P-H, O-H, S-H, and C-H insertion reactions of trifluoroacetaldehyde N-tosylhydrazone revealed its wide applicability in the synthesis of trifluoroethyl-containing substances.

Organic Letterspublished new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Safety of 4,5-Dihydrothiazole-2-thiol.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Dammann, Allison N.; Chamby, Anna B.; Catomeris, Andrew J.; Davidson, Kyle M.; Tettelin, Herve; van Pijkeren, Jan-Peter; Gopalakrishna, Kathyayini P.; Keith, Mary F.; Elder, Jordan L.; Ratner, Adam J.; Hooven, Thomas A. published the artcile< Genome-Wide fitness analysis of group B Streptococcus in human amniotic fluid reveals a transcription factor that controls multiple virulence traits>, Product Details of C11H8N2O3S2, the main research area is genome fitness analysis Streptococcus human amniotic fluid transcription factor; virulence trait.

Streptococcus agalactiae (group B Streptococcus; GBS) remains a dominant cause of serious neonatal infections. One aspect of GBS that renders it particularly virulent during the perinatal period is its ability to invade the chorioamniotic membranes and persist in amniotic fluid, which is nutritionally deplete and rich in fetal immunol. factors such as antimicrobial peptides. We used next-generation sequencing of transposon-genome junctions (Tn-seq) to identify five GBS genes that promote survival in the presence of human amniotic fluid. We confirmed our Tn-seq findings using a novel CRISPR inhibition (CRISPRi) gene expression knockdown system. This anal. showed that one gene, which encodes a GntR-class transcription factor that we named MrvR, conferred a significant fitness benefit to GBS in amniotic fluid. We generated an isogenic targeted deletion of the mrvR gene, which had a growth defect in amniotic fluid relative to the wild type parent strain. The mrvR deletion strain also showed a significant biofilm defect in vitro. Subsequent in vivo studies showed that while the mutant was able to cause persistent murine vaginal colonization, pregnant mice colonized with the mrvR deletion strain did not develop preterm labor despite consistent GBS invasion of the uterus and the fetoplacental units. In contrast, pregnant mice colonized with wild type GBS consistently deliver prematurely. In a sepsis model the mrvR deletion strain showed significantly decreased lethality. In order to better understand the mechanism by which this newly identified transcription factor controls GBS virulence, we performed RNA-seq on wild type and mrvR deletion GBS strains, which revealed that the transcription factor affects expression of a wide range of genes across the GBS chromosome. Nucleotide biosynthesis and salvage pathways were highly represented among the set of differentially expressed genes, suggesting that MrvR may be involved in regulating nucleotide availability.

PLoS Pathogenspublished new progress about Amniotic fluid. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Product Details of C11H8N2O3S2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Luo, Kai; Chen, Yao-Zhong; Chen, Li-Xian; Wu, Lei published the artcile< Autoxidative C(sp2)-P Formation: Direct Phosphorylation of Heteroarenes under Oxygen, Metal-Free, and Solvent-Free Conditions>, Category: thiazole, the main research area is phosphorylation heteroarene arylphosphine oxide; heteroaryl phosphine oxide preparation.

The authors reveal here a direct autoxidative phosphorylation of heteroarenes induced by O under metal-free and solvent-free conditions. This new methodol. provides an economical, operationally simple, and environmentally friendly approach toward (Het)C(sp2)-P formation with medium to excellent yields. Heteroarenes including thiazole and quinoxaline derivatives are applicable under standard conditions, which is testified via a radical mechanism.

Journal of Organic Chemistrypublished new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroarenes). 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Inouye, Satoshi; Sahara-Miura, Yuiko; Nakamura, Mitsuhiro; Hosoya, Takamitsu published the artcile< Expression, purification, and characterization of recombinant apoPholasin>, COA of Formula: C11H8N2O3S2, the main research area is apoPholasin glutathione transferase coelenterazine reactive oxygen species oxidation; Coelenteramide; Coelenteramine; Dehydrocoelenterazine; Photoproteins; Reactive oxygen.

Pholasin is a reactive oxygen-sensitive photoprotein that consists of an apoprotein (apoPholasin) and an unknown chromophore. The preferred human codon-optimized apoPholasin gene was transiently expressed in mammalian cells and apoPholasin was detected using an anti-recombinant apoPholasin antibody. For the first time, we found that apoPholasin secreted into the culture medium could catalyze the oxidation of coelenterazine (CTZ, a luciferin) to produce continuous luminescence. The fusion protein of apoPholasin and glutathione S-transferase (GST-apoPholasin) was successfully expressed as a soluble form in bacterial cells using the cold induction system. The purified GST-apoPholasin also had luminescence activity with CTZ, showing the bioluminescence emission peak at 461 nm, and the resultant product showed purple blue fluorescence under 365 nm light. Unexpectedly, the main oxidation product of CTZ was identified as coelenteramine (CTM), not coelenteramide (CTMD).

Protein Expression and Purificationpublished new progress about Absorption. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, COA of Formula: C11H8N2O3S2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sun, Wencheng; Teng, Qiaoling; Cheng, Dongping; Li, Xiaonian; Xu, Xiaoliang published the artcile< The hydrodebromination of 1,1-dibromoalkenes via visible light catalysis>, Electric Literature of 1003-32-3, the main research area is dibromoalkene preparation iridium photocatalyst diastereoselective hydrodebromination green chem; bromoalkene preparation.

A hydrodebromination reaction of 1,1-dibromoalkenes was established via visible light catalysis. A variety of structurally different vinyl bromides were obtained in moderate to excellent yields.

Tetrahedron Letterspublished new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Electric Literature of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wu, Yue-Xiao; Peng, Kang; Hu, Zhi-Chao; Fan, Yong-Hao; Shi, Zhen; Hao, Er-Jun; Dong, Zhi-Bing published the artcile< Iodine-Mediated Cross-Dehydrogenative Coupling of Heterocyclic Thiols with Amines: An Easy and Practical Formation of S-N Bond>, Quality Control of 96-53-7, the main research area is amine heteroaryl thiol iodine promoter cross dehydrogenative coupling; heteroaryl sulfenamide preparation.

An efficient iodine-mediated construction of S-N bond was developed. Such a cross-dehydrogenative coupling of heterocyclic thiols with amines proceeded smoothly under metal-free and base-free conditions, and afforded a series of sulfenamides in good to excellent yields. The easily available substrates and convenient synthetic procedure illustrate potential synthetic value of this protocol for the preparation of sulfenamide related biol. or pharmaceutically active compounds

European Journal of Organic Chemistrypublished new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Quality Control of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica