Author: tianli

Product class 18: benzothiazoles and related compounds was written by Ulrich, H.. And the article was included in Science of Synthesis in 2002.Electric Literature of C13H10N2S This article mentions the following:

Methods for preparing benzothiazoles and related annulated thiazoles are reviewed. Preparative methods include ring-closure reactions, ring transformations, aromatization and synthesis by substituent modification. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Electric Literature of C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Electric Literature of C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

QSAR study on H₃-receptor affinity of benzothiazole derivatives of thioperamide was written by Bordi, Fabrizio;Mor, Marco;Morini, Giovanni;Plazzi, Pier Vincenzo;Silva, Claudia;Vitali, Tullo;Caretta, Antonio. And the article was included in Farmaco in 1994.Application of 80945-86-4 This article mentions the following:

Starting from the structure of thioperamide, a known H₃-antagonist, a new series of compounds I (R = H, NO₂, Br, etc.) with a benzothiazole nucleus instead of the cyclohexylcarbothioamide moiety was synthesized. Various substituents, selected by exptl. design, were introduced in position 6 of the benzothiazole nucleus, in order to change its physico-chem. characteristics. The lipophilicity of the synthesized compounds was measured by means of RP-HPLC, and their H₃-receptor affinity was evaluated by competitive binding assays on rat cortex synaptosomes, with the labeled ligand N^α-[³H]methylhistamine. A QSAR anal. was performed on the exptl. data, using also substituent constants taken from the literature. The newly synthesized compounds showed lower H₃-affinities than thioperamide; quant. structure-activity relationships, described by models obtained with PLS and MRS techniques, were observed among benzothiazole derivatives According to these relationships, any attempt to improve the potency of these compounds should involve the substitution of the benzothiazole moiety with less bulky and/or more flexible structures, which should also be less lipophilic and allow better electronic interactions with the binding site. 1-(Benzothiazol-2-yl)-4-[(1H)-imidazol-4-yl]piperidine represents a limit structure for H₃-activity, since it seems impossible to improve its affinity by means of substitution in the studied position of the benzothiazole nucleus, as shown by predictions performed by a PLS model. In the experiment, the researchers used many compounds, for example, 6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4Application of 80945-86-4).

6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Application of 80945-86-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis and investigations of the absorption spectra of hetarylazo disperse dyes derived from 2,4-quinolinediol was written by Sener, Izzet;Karci, Fikret;Ertan, Nermin;Kilic, Emine. And the article was included in Dyes and Pigments in 2005.Synthetic Route of C4H6N2S This article mentions the following:

Synthesis of 9 hetarylazoquinoline dyes was achieved by diazotization of nine heterocyclic amines using nitrosyl sulfuric acid and then coupling with 2,4-quinolinediol. These dyes were characterized by UV-visible, FT-IR, and ¹H NMR spectroscopic techniques and elemental anal. Visible absorption spectra of the dyes are discussed in terms of the effects of varying pH and solvent on the absorption ability of azoquinolines. The colors of the dyes were discussed with respect to the nature of the heterocyclic ring and to the substituents thereon. Temperature and concentration effects on the visible absorption maxima of the dyes are also reported. In the experiment, the researchers used many compounds, for example, 2-Methylthiazol-5-amine (cas: 89281-44-7Synthetic Route of C4H6N2S).

2-Methylthiazol-5-amine (cas: 89281-44-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Synthetic Route of C4H6N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Cyclization of 1-arylthiosemicarbazides into benzothiazoles was written by Kost, A. N.;Lebedenko, N. Yu.;Sviridova, L. A.;Torocheshnikov, V. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1978.Product Details of 1843-21-6 This article mentions the following:

Benzothiazoles I (R, R¹, R² = H, Cl, Me, R³ = H, Me, Ph) were obtained by cyclization of RR¹R²C₆H₂NHNHCSNHR³ with polyphosphoric acid. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Product Details of 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Product Details of 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Direct transition metal-free C-S bond formation: synthesis of 2-aminobenzothiazole derivatives via base-mediated approach was written by Wang, Rui;Chen, Zhi;Yue, Liang;Pan, Wei;Zhao, Jun-Jie. And the article was included in Tetrahedron Letters in 2012.Name: N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

A general, efficient, and more practical protocol for the base-mediated intermol. or intramol. S-arylation leading to the 2-aminobenzothiazole derivatives, e.g., I (R¹ = H, Me, Meo, F, Cl; R² = H, Me, Cl, Br, NO₂), is reported. Remarkably, all reactions were carried out under transition-metal-free conditions with good to excellent yields, rendering the methodol. presented herein highly valuable from both environmental and economic points of view. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Name: N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Name: N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A Novel Route to Substituted 2-(N-Arylamino)benzothiazoles via Iron-Promoted C-S Bond Formation was written by Pinapati, Srinivasa Rao;Mandapati, Usha Rani;Tamminana, Ramana;Rudraraju, Ramesh Raju. And the article was included in ChemistrySelect in 2019.Computed Properties of C13H10N2S This article mentions the following:

The synthesis of 2-(N-arylamino)benzothiazoles I (R = Bu, cyclohexyl, 2-nitrophenyl, etc.; R¹ = H, 5-Me, 7-NO₂, etc.) has been demonstrated in the presence of transition metal under mild reaction conditions. In this paper, disubstituted thioureas R²NHC(S)NHR (R² = 2-iodo-4-methylphenyl, 2-iodo-6-nitrophenyl, 4,5-dimethyl-2-iodophenyl, etc.) have also been reported from isothiocyanates R²NCS at room temperature Subsequently, C-S cross-coupling reaction was described for the construction of benzothiazoles I using cheap, readily available and air stable iron catalyst. Moreover, no other byproducts could be observed except target products. Furthermore, control experiments were performed for reveal the mechanism. In addition, a broad range of substrate scope has been explored. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Computed Properties of C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Computed Properties of C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reactions of 2-aminobenzothiazoles with phenyl glycidyl ether was written by Ambartsumova, R. F.;Kosmacheva, L. P.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1991.Recommanded Product: N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

Aminobenzothiazoles I (R = H, Me, Et, Ph, CH₂Ph, COMe, cyclohexyl; R¹ = H) react with Ph glycidyl ether at the ring N atom to form II, while in base the reaction takes place at the amino group to give phenoxypropylamino derivatives, e.g., I [R = CH₂CH(OH)CH₂OPh]. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Recommanded Product: N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Recommanded Product: N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis of Fluorinated and Nonfluorinated Tebufenpyrad Analogues for the Study of Anti-angiogenesis MOA was written by Roman, Raquel;Navarro, Antonio;Wodka, Dariusz;Alvim-Gaston, Maria;Husain, Saba;Franklin, Natalie;Simon-Fuentes, Antonio;Fustero, Santos. And the article was included in Organic Process Research & Development in 2014.Related Products of 55661-33-1 This article mentions the following:

In this contribution we report the synthesis of fluorinated and nonfluorinated tebufenpyrad analogs to explore potential druglike properties through the phenotypic screening as part of the Lilly Open Innovation Drug Discovery (OIDD) program. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Related Products of 55661-33-1).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Related Products of 55661-33-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Novel acyl coenzyme A: diacylglycerol acyltransferase 1 inhibitors-synthesis and biological activities of N-(substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides was written by Nakada, Yoshihisa;Ogino, Masaki;Asano, Kouhei;Aoki, Kazuko;Miki, Hiroshi;Yamamoto, Toshihiro;Kato, Koki;Masago, Minori;Tamura, Norikazu;Shimada, Mitsuyuki. And the article was included in Chemical & Pharmaceutical Bulletin in 2010.Category: thiazole This article mentions the following:

In a program to discover new small mol. diacylglycerol acyltransferase (DGAT)-1 inhibitors, screening of our inhouse chem. library was carried out using recombinant human DGAT-1 enzyme. From this library, the lead compound 1a (I) was identified as a new class of DGAT-1 inhibitor. A series of novel N-(substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides 2 was designed from 1a, synthesized and evaluated for inhibitory activity against DGAT-1 enzyme. Among these compounds, N-(5-benzyl-4-phenyl-1,3-thiazol-2-yl)-4-(4,5-diethoxy-2-methylphenyl)-4-oxobutanamide 9 was found to exhibit potent inhibitory activity and good enzyme selectivities. Following administration in KKA^y mice with 3 mg/kg high fat diet admixture for four weeks, 9 reduced body weight gain and white adipose tissue weight without affecting total food intake. These results suggested that the small mol. DGAT-1 inhibitor might have potential in the treatment of obesity and metabolic syndrome. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Category: thiazole).

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A grand product design model for crystallization solvent design was written by Chai, Shiyang;Liu, Qilei;Liang, Xinyuan;Guo, Yansuo;Zhang, Song;Xu, Chengqiu;Du, Jian;Yuan, Zhihong;Zhang, Lei;Gani, Rafiqul. And the article was included in Computers & Chemical Engineering in 2020.Application of 1843-21-6 This article mentions the following:

Solvents play an important role in crystallization processes. The screening/design of solvents for crystallization (crystallization solvents) is still of great concern in research and development. At present, most of the design/screening methods of crystallization solvents are still based on the trial-and-error approach. In this paper, the Grand Product Design (GPD) model is applied for the screening/design of crystallization solvents. The GPD-model includes process sub-model, property sub-model, quality sub-model, cost sub-model, pricing sub-model, economic sub-model and environmental sub-model as well as other factors such as company strategy, government policies and regulations. Solution strategies are given for three cases: solvent design for a fixed process, process design for a fixed solvent and simultaneous design of solvent and process. Taking 2-Mercapotobenzothiazole (MBT) as an example, the solvent design for a fixed (existing) process design is carried out by using the problem specific GPD-model, in which the GPD-model is formulated as Mixed-Integer Non-Linear Programming (MINLP) model with objective function, process sub-model, property sub-model, quality sub-model, pricing sub-model, cost sub-model, economic sub-model and environmental sub-model. The established MINLP model is then solved by the decomposition-based approach. Experiments are carried out to verify the candidate solvents, which is found to perform better in terms of product purity and recovery than the best-known solvents in use. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Application of 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Application of 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica