Author: tianli

In an article, published in an article, once mentioned the application of 1123-93-9, Name is 1,3-Benzothiazol-5-amine,molecular formula is C7H6N2S, is a conventional compound. this article was the specific content is as follows.name: 1,3-Benzothiazol-5-amine

The invention relates to trifluoromethyl substituted benzamide compounds of the formula I, [image] pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases, especially of ephrin receptor kinases, and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.

The invention relates to trifluoromethyl substituted benzamide compounds of the formula I, [image] pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases, especially of ephrin receptor kinases, and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.

Do you like my blog? If you like, you can also browse other articles about this kind. name: 1,3-Benzothiazol-5-amine. Thanks for taking the time to read the blog about 1123-93-9

Reference£º
Thiazole | C3H282NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 886361-30-4, Name is Methyl 2-amino-5-(4-fluorophenyl)thiazole-4-carboxylate, molecular formula is C11H9FN2O2S. In a Patent£¬once mentioned of 886361-30-4, Formula: C11H9FN2O2S

The invention relates to oxazolidine derivatives of the formula (I) wherein A, B, and R 1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially as orexin receptor antagonists

The invention relates to oxazolidine derivatives of the formula (I) wherein A, B, and R 1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially as orexin receptor antagonists

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C11H9FN2O2S. In my other articles, you can also check out more blogs about 886361-30-4

Reference£º
Thiazole | C3H8408NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 105827-91-6, Name is 2-Chloro-5-(chloromethyl)thiazole, molecular formula is C4H3Cl2NS. In a Patent£¬once mentioned of 105827-91-6, Quality Control of: 2-Chloro-5-(chloromethyl)thiazole

The invention discloses a 2 – chloro – 5 – chloromethyl-thiazole of the preparation method, comprises the following steps: S1, will be 1 – isothiocyanate yl – 2 – chloro – 2 – propylene adding organic solvent, at a temperature of 5 C -20 C to proceed chlorination reaction; S2, recycling the organic solvent, the gas hydrogen chloride derived; S3, organic solvent recovery after the completion of the, heating up and through the distilled under reduced pressure to get the pure product 2 – chloro – 5 – chloromethyl-thiazole. According to the embodiment of the invention of 2 – chloro – 5 – chloromethyl-thiazole of the preparation method using a large amount of hydrochloric acid in the refining process, has simplified the reaction step, mild reaction conditions, there is no three waste, high yield, in line with the direction of development of green chemistry. (by machine translation)

The invention discloses a 2 – chloro – 5 – chloromethyl-thiazole of the preparation method, comprises the following steps: S1, will be 1 – isothiocyanate yl – 2 – chloro – 2 – propylene adding organic solvent, at a temperature of 5 C -20 C to proceed chlorination reaction; S2, recycling the organic solvent, the gas hydrogen chloride derived; S3, organic solvent recovery after the completion of the, heating up and through the distilled under reduced pressure to get the pure product 2 – chloro – 5 – chloromethyl-thiazole. According to the embodiment of the invention of 2 – chloro – 5 – chloromethyl-thiazole of the preparation method using a large amount of hydrochloric acid in the refining process, has simplified the reaction step, mild reaction conditions, there is no three waste, high yield, in line with the direction of development of green chemistry. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 2-Chloro-5-(chloromethyl)thiazole. In my other articles, you can also check out more blogs about 105827-91-6

Reference£º
Thiazole | C3H2915NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.65948-19-8, Name is 6-Phenoxybenzo[d]thiazol-2-amine, molecular formula is C13H10N2OS. In a Article£¬once mentioned of 65948-19-8, Application In Synthesis of 6-Phenoxybenzo[d]thiazol-2-amine

We report the synthesis and biological activity of a low molecular weight non-peptidic mimic of the analgesic peptide omega-conotoxin GVIA. The molecular weight of this compound presents a reduction by 193 g/mol compared to a previously reported lead. This compound exhibits an EC50 of 5.8 muM and is accessible in only six synthetic steps compared to the original lead (13 steps). We also report several improvements to the original synthetic route. Crown Copyright

We report the synthesis and biological activity of a low molecular weight non-peptidic mimic of the analgesic peptide omega-conotoxin GVIA. The molecular weight of this compound presents a reduction by 193 g/mol compared to a previously reported lead. This compound exhibits an EC50 of 5.8 muM and is accessible in only six synthetic steps compared to the original lead (13 steps). We also report several improvements to the original synthetic route. Crown Copyright

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 65948-19-8 is helpful to your research., Application In Synthesis of 6-Phenoxybenzo[d]thiazol-2-amine

Reference£º
Thiazole | C3H7406NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 348-40-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Article£¬once mentioned of 348-40-3

Novel N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)- carbothioamide derivatives were synthesized and evaluation of their anticonvulsant effects was done using various models of experimental epilepsy. Initial anticonvulsant activities of the compounds were investigated using intraperitoneal (i.p.) maximal electroshock shock (MES), subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The quantitative assessment after oral administration in rats showed that the most active was 2-methyl-4-oxo-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylcarbamoyl) quinazoline-3(4H)-carbothioamide (SA 24) with ED50 values of 82.5 mumol/kg (MES) and 510.5 mumol/kg (scPTZ). This molecule was more potent than phenytoin and ethosuximide which were used as reference antiepileptic drugs. To explain the possible mechanism for anticonvulsant action, some of the selected active compounds were subjected to GABA (gamma-amino butyric acid) assay and AMPA ((S)-2-amino-3-(3-hydroxyl-5-methyl-4-isoxazolyl) propionic acid) induced seizure test.

Novel N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)- carbothioamide derivatives were synthesized and evaluation of their anticonvulsant effects was done using various models of experimental epilepsy. Initial anticonvulsant activities of the compounds were investigated using intraperitoneal (i.p.) maximal electroshock shock (MES), subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The quantitative assessment after oral administration in rats showed that the most active was 2-methyl-4-oxo-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylcarbamoyl) quinazoline-3(4H)-carbothioamide (SA 24) with ED50 values of 82.5 mumol/kg (MES) and 510.5 mumol/kg (scPTZ). This molecule was more potent than phenytoin and ethosuximide which were used as reference antiepileptic drugs. To explain the possible mechanism for anticonvulsant action, some of the selected active compounds were subjected to GABA (gamma-amino butyric acid) assay and AMPA ((S)-2-amino-3-(3-hydroxyl-5-methyl-4-isoxazolyl) propionic acid) induced seizure test.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 348-40-3 is helpful to your research., Related Products of 348-40-3

Reference£º
Thiazole | C3H10450NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2516-40-7, Name is 2-Bromobenzothiazole, molecular formula is C7H4BrNS. In a Article£¬once mentioned of 2516-40-7, Recommanded Product: 2-Bromobenzothiazole

A series of Pd(II)-enaminone complexes, termed Pd(eao)2, have been synthesized and characterized. The investigation on the catalytic activities of these new Pd(II)-reagents has proved that the Pd(eao)2-1 possesses excellent catalytic activity for the Suzuki- Miyaura cross coupling reactions of aryl bromides/chlorides with aryl/vinyl boronic acids in the environmentally benign media of aqueous PEG400 at low loading (5 mol?). The superiority of this Pd(II)-reagent to those commercial Pd(II) and Pd(0) catalysts in catalyzing the reactions has been confirmed by parallel experiments. What’s more, Pd(eao)2-2 has been found as a practical catalyst for the homo-coupling reactions of aryl boronic acids.

A series of Pd(II)-enaminone complexes, termed Pd(eao)2, have been synthesized and characterized. The investigation on the catalytic activities of these new Pd(II)-reagents has proved that the Pd(eao)2-1 possesses excellent catalytic activity for the Suzuki- Miyaura cross coupling reactions of aryl bromides/chlorides with aryl/vinyl boronic acids in the environmentally benign media of aqueous PEG400 at low loading (5 mol?). The superiority of this Pd(II)-reagent to those commercial Pd(II) and Pd(0) catalysts in catalyzing the reactions has been confirmed by parallel experiments. What’s more, Pd(eao)2-2 has been found as a practical catalyst for the homo-coupling reactions of aryl boronic acids.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 2-Bromobenzothiazole, you can also check out more blogs about2516-40-7

Reference£º
Thiazole | C3H2745NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 10200-59-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 10200-59-6, Name is 2-Thiazolecarboxaldehyde, molecular formula is C4H3NOS. In a Article£¬once mentioned of 10200-59-6

Reductive alkylation of 3-amino-12-N-methylcytisine by aromatic aldehydes synthesized a series of secondary amines. The nootropic activity of the synthesized compounds was studied in vivo (mnestic and antihypoxic properties) and in vitro (antiradical properties and ability to affect transcription factor HIF-1 DNA-binding activity). The cytotoxicity of the synthesized compounds was assessed. The lead compound was identified.

Reductive alkylation of 3-amino-12-N-methylcytisine by aromatic aldehydes synthesized a series of secondary amines. The nootropic activity of the synthesized compounds was studied in vivo (mnestic and antihypoxic properties) and in vitro (antiradical properties and ability to affect transcription factor HIF-1 DNA-binding activity). The cytotoxicity of the synthesized compounds was assessed. The lead compound was identified.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 10200-59-6 is helpful to your research., Application of 10200-59-6

Reference£º
Thiazole | C3H4270NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole,molecular formula is C14H11NS, is a conventional compound. this article was the specific content is as follows.SDS of cas: 16112-21-3

A new, convenient synthesis of 2-substituted benzimidazoles and benzothiazoles is described. Short reaction time, easy and quick isolation of the products, environmentally friendly procedure, excellent chemoselectivity and excellent yields are main advantages of this procedure. Georg Thieme Verlag Stuttgart.

A new, convenient synthesis of 2-substituted benzimidazoles and benzothiazoles is described. Short reaction time, easy and quick isolation of the products, environmentally friendly procedure, excellent chemoselectivity and excellent yields are main advantages of this procedure. Georg Thieme Verlag Stuttgart.

Do you like my blog? If you like, you can also browse other articles about this kind. SDS of cas: 16112-21-3. Thanks for taking the time to read the blog about 16112-21-3

Reference£º
Thiazole | C3H856NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine,molecular formula is C7H5FN2S, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 6-Fluorobenzo[d]thiazol-2-amine

New fluorinated 2-aryl-benzothiazoles, -benzoxazoles, and -chromen-4-ones have been synthesized and their activity against MCF-7 and MDA 468 breast cancer cell lines compared with the potent antitumor benzothiazole 5. Analogues such as 9a,b and 12a,d yielded submicromolar GI50 values in both cell lines; however, none of the new compounds approached 5 in terms of antitumor potency. For 5, binding to the aryl hydrocarbon receptor appeared to be necessary but not sufficient for growth inhibition.

New fluorinated 2-aryl-benzothiazoles, -benzoxazoles, and -chromen-4-ones have been synthesized and their activity against MCF-7 and MDA 468 breast cancer cell lines compared with the potent antitumor benzothiazole 5. Analogues such as 9a,b and 12a,d yielded submicromolar GI50 values in both cell lines; however, none of the new compounds approached 5 in terms of antitumor potency. For 5, binding to the aryl hydrocarbon receptor appeared to be necessary but not sufficient for growth inhibition.

Do you like my blog? If you like, you can also browse other articles about this kind. Recommanded Product: 6-Fluorobenzo[d]thiazol-2-amine. Thanks for taking the time to read the blog about 348-40-3

Reference£º
Thiazole | C3H10458NS – PubChem,
Thiazole | chemical compound | Britannica

16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 16112-21-3, Quality Control of: 2-(4-Methylphenyl)benzothiazole

An efficient one pot synthesis of 2-arylbenzothiazole derivatives through condensation of aldehydes and 2-aminothiophenol in the presence of catalytic amount of La(NO3)3¡¤6H2O under mild reaction conditions was developed. The key advantages of this protocol are short reaction time, high to excellent yields, simple work up, inexpensive catalyst and simple separation of pure product.

An efficient one pot synthesis of 2-arylbenzothiazole derivatives through condensation of aldehydes and 2-aminothiophenol in the presence of catalytic amount of La(NO3)3¡¤6H2O under mild reaction conditions was developed. The key advantages of this protocol are short reaction time, high to excellent yields, simple work up, inexpensive catalyst and simple separation of pure product.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 2-(4-Methylphenyl)benzothiazole. In my other articles, you can also check out more blogs about 16112-21-3

Reference£º
Thiazole | C3H775NS – PubChem,
Thiazole | chemical compound | Britannica