Category: 100367-77-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.100367-77-9,Ethyl 2-bromothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Step 3 : (2-bromothiazol-4-yl)methanolA solution of ethyl 2-bromothiazole-4-carboxylate (7.821 g, 33.13 mmol) in THF (100 mL) was cooled in an ice-bath and treated portionwise with lithium borohydride (1.083 g, 49.70 mmol). After 1 hour MeOH (1.614 g, 2.040 mL, 50.36 mmol) was added over a period of half an hour. The reaction was allowed to stir for 3 hours and then the solvent was concentrated in vacuo and the resultant residue was dissolved in EtOAc, washed with HCl (2x), saturated sodium bicarbonate, followed by brine, dried (Na2SO4), concentrated and purified by column chromatography (EtOAc/Petroleum ether 1: 1) to give the required product as a colorless oil (4.3Og, 67percent Yield). 1H NMR (CDCl3, 400 MHz) delta 2.51 (IH, m), 4.75 (2H, m), 7.19 (IH, s); MS (ES+) 195.96, 100367-77-9

100367-77-9 Ethyl 2-bromothiazole-4-carboxylate 353965, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; JIMENEZ, Juan-Miguel; COLLIER, Philip, N.; WO2010/129668; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

100367-77-9, Ethyl 2-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl 2-bromothiazole-4-carboxylate (97 mg, 0.409 mmol) was dissolved in a solvent mixture of ethanol (15 mL) and water (7.5 mL) and treated with aqueous sodium hydroxide (2.50 M, 2.54 mL). The mixture was stirred at 35 C for 30 minutes, and then partitioned between ethyl acetate (100 mL) and HCl (1.0 M, 100 mL). The organic phase was dried (sodium sulfate) and concentrated to afford the carboxylic acid as a white solid. To a solution of this material in pyridine (5 mL) were added 4-aminopyridine (46.1 mg, 0.490 mmol), HOBt (78 mg, 0.511 mmol), DMAP (10.0 mg, 0.082 mmol) and EDAC (117 mg, 0.613 mmol). The reaction mixture was stirred at room temperature for 18 hours then filtered through a frit The filtrate was concentrated in vacuo and purified by preparative HPLC [Waters Nova- Pak HR Cl 8 6mum 60A Prep-Pak cartridge column (40 x 100 mm), 10%-100% gradient of acetonitrile in 10 mM aqueous ammonium acetate over 12 minutes at a flow rate of 70 mL/minute] to provide the titled compound: 1H NMR (400 MHz, methanol-D4) delta ppm 7.83 – 7,90 (m, 2 H), 840 (s, 1 H), 8.43 – 8.46 (m, 2 H). MS (ESI) m/z = 284/286 (M+H)+., 100367-77-9

The synthetic route of 100367-77-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; WO2008/58096; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica