Category: 1025700-49-5

1025700-49-5, 2-Amino-5-bromo-4-isopropylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3 5-Bromo-4-isopropyl-thiazole Concentrated nitric acid (4 mL) was slowly added to 5-bromo-4-isopropyl-thiazol-2-ylamine (2.05 g, 9 mmol), and concentrated phosphoric acid (14 mL) was added dropwise over five minutes. The mixture was cooled to -5 C., and a solution of sodium nitrite (0.768 g, 11 mmol) in 5 mL water was added dropwise over a 15 minute period. The reaction mixture was stirred at -5 C. for 30 minutes, and an aqueous solution of H3PO2 (6 mL, 50% weight in water) was slowly added. The reaction mixture was stirred at -5 C. for 2.5 hours, then stirred at room temperature for 18 hours. The reaction mixture was cooled to 0 C. and quenched by addition of aqueous NaOH (30% weight solution). The mixture was extracted with methylene chloride, and the combined organic extracts were washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The resulting oil was chromatographed (10% EtOAc in hexanes) to give 236 mg of 5-bromo-4-isopropyl-thiazole as an oil, MS (M+H)=207., 1025700-49-5

The synthetic route of 1025700-49-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Chen, Li; Dillon, Michael Patrick; Feng, Lichun; Hawley, Ronald Charles; Yang, Minmin; US2012/22067; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1025700-49-5,2-Amino-5-bromo-4-isopropylthiazole,as a common compound, the synthetic route is as follows.,1025700-49-5

Step 3 5-Bromo-4-isopropyl-thiazole; Concentrated nitric acid (4 mL) was slowly added to 5-bromo-4-isopropyl-thiazol-2-yl- amine (2.05 g, 9 mmol), and concentrated phosphoric acid (14 mL) was added dropwise over 5 min. The mixture was cooled to -5C, and a solution of sodium nitrite (0.768 g, 11 mmol) in 5 mL water was added dropwise over a 15 min period. The reaction mixture was stirred at -5C for 30 min, and an aqueous solution of H3PO2 (6 mL, 50% weight in water) was slowly added. The reaction mixture was stirred at -5C for 2.5 h, then stirred at RT for 18 h. The reaction mixture was cooled to 00C and quenched by addition of aqueous NaOH (30% weight solution). The mixture was extracted with methylene chloride, and the combined organic extracts were washed with brine, dried (MgSO/O, filtered and concentrated under reduced pressure. The resulting oil was chromato- graphed (10% EtOAc in hexanes) to give 236 mg of 5-bromo-4-isopropyl-thiazole as an oil, MS (M+H) = 207.

As the paragraph descriping shows that 1025700-49-5 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/55840; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica