Category: 103878-58-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103878-58-6,5-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

(b) 5-bromo-N-cyclopropyl- 1, 3-thiazole-4-carboxam ide To a solution of 5-bromo-1,3-thiazole-4-carboxylic acid (3.09 g, 14.85 mmol) in DCM (75 mL) was added DIPEA (5.17 mL, 29.71 mmol) followed by cyclopropylamine (1.18 mL, 17.08 mmol) and HATU (6.21 g, 16.34 mmol). The reaction mixture was allowed to stir at room temperature for 6 h. The mixture was then diluted with H20 (50 mL) and the layers were separated. The aqueous layer was further extracted with DCM (3 x 25 mL) and the combined organics dried over MgSO4, filtered and concentrated under reduced pressure. The crude reaction product was purified by flash chromatography eluting with a gradient system of 0-50% EtOAc in Petroleum ether (40-60) to give 5-bromo-N-cyclopropyl-1,3- thiazole-4-carboxamide (2.88 g, 78 % yield) as a white solid. LC-MS (Method D) 247.2/249.2 [M+H] RT 1.82 mm

103878-58-6, The synthetic route of 103878-58-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; REDX PHARMA PLC; RATCLIFFE, Andrew; HUXLEY, Anthony; LYTH, David; NOONAN, Gary; KIRK, Ralph; UOSIS-MARTIN, Mario; STOKES, Neil; WO2015/155549; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of compound LXXX 2 (0.7 g, 3.37 mmol), compound LXXX-2A (0.53 g, 4.36 mmol), TEA (677 mg, 6.7 mmol) in toluene (10 mL) was added DPPA (1.2 g, 4.36 mmol) under nitrogen. After the addition, the solution was heated to reflux under nitrogen over night. The solution was concentrated. The residue was purified by column chromatography on silica gel (Petroleum ether:EtOAc = 3: 1) to afford compound LXXX-3 (0.76 g, yield 69%). MS (ESI) m/z (M+Na)+ 350.9., 103878-58-6

103878-58-6 5-Bromothiazole-4-carboxylic acid 21297375, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.; WO2013/25733; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-1 ,3-thiazole-4-carboxylic acid (3.09 g, 14.85 mmol) in DCM (75 mL) was added DIPEA (5.17 mL, 29.71 mmol) followed by cyclopropylamine (1.18 mL, 17.08 mmol) and HATU (6.21 g, 16.34 mmol). The reaction mixture was allowed to stir at room temperature for 6 h. The mixture was then diluted with H2O (50 mL) and the layers were separated. The aqueous layer was further extracted with DCM (3 chi 25 mL) and the combined organics dried over MgSCU, filtered and concentrated under reduced pressure. The crude reaction product was purified by flash chromatography eluting with a gradient system of 0-50% EtOAc in Petroleum ether (40-60) to give 5-bromo-N-cyclopropyl-1 ,3- thiazole-4-carboxamide (2.88 g, 78 % yield) as a white solid.LC-MS (Method D) 247.2/249.2 [M+H]+; RT 1.82 min, 103878-58-6

103878-58-6 5-Bromothiazole-4-carboxylic acid 21297375, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; REDX PHARMA PLC; STOKES, Neil; (163 pag.)WO2017/46603; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

150 mg (0.43 mmol) of 5-bromo-thiazole-4-carboxylic acid and 81.4 mg (0.87 mmol) of pyridin-3-yl-amine were dissolved in 6 ml dimethyl formamide. 0.09 mL (0.65 mmol) of triethyl amine followed by 225 mg (0.43 mmol) of 1H-benzotriazol-1-yloxytri-pyrrolidinophosphonium hexafluorophosphate (PyBOP) were added and the reaction mixture was stirred at room temperature for 16 h. Brine was added and the reaction mixture was extracted two times with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered and the solvent was removed under reduced pressure. The obtained residue was purified by flash column chromatography (silica, gradient elution cyclohexane?ethyl acetate?methanol) to give 90 mg (66%, 90% purity) of the title compound

103878-58-6, As the paragraph descriping shows that 103878-58-6 is playing an increasingly important role.

Reference：
Patent; BASF SE; Le Vezouet, Ronan; Soergel, Sebastian; Defieber, Christian; Gross, Steffen; Koerber, Karsten; Culbertson, Deborah L.; Anspaugh, Douglas D.; US9125414; (2015); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103878-58-6,5-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Intermediate 12 5-Bromothiazole-4-carboxylic acid (2.17g, 10.4mmol) was dissolved in dry dioxan (170ml_) and heated at 100C. To this, Lambda/,/V-dimethyl-formamide di-tert-butyl acetal (13.68g, 67.28mmol) was added drop wise and the mixture stirred at 100C for 1 hour. The mixture was cooled to room temperature and stirred for 18 hours. The volatile solvents were removed in vacuo and the residue partitioned between water and diethyl ether. The organic layer was washed with saturated NaHC03, dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-20% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 12 (2.8g) as a yellow solid. 1 H NMR (CDCIs) delta: 8.76 (1 H, s), 1 .63 (9H, s) LCMS (Method 2) Rt 3.23 min; m/z(M+H)+ 265

103878-58-6, 103878-58-6 5-Bromothiazole-4-carboxylic acid 21297375, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 12-(5-Bromo-thiazol-4-yl)-5-methyl- 1 H-benzoimidazole A solution of 5-bromo-thiazole-4-carboxylic acid (1.37 g, 6.59 mmol, commercially available from Combi-blocks), diisopropylethylamine (1.49 mL, 8.57 mmol), 4-methyl-beiizene-1,2- diamine (0.88 g, 7.25 mmol) in DMF (11 mL) at room temperature was treated with TBTU (2.75 g, 8.57 mmol) and the mixture stirred at room temperature for 18 h. The solvents were thenevaporated under vacuum and the residue partitioned between ethyl acetate and saturated solution of sodium bicarbonate, the organics were collected and dried with magnesium sulfate and then concentrated under vacuum. The crude mixture was dissolved in acetic acid (12 mL), transferred to microwave vial and the mixture was heated at 150 C in a microwave reactor for 1.5 h. After solvent evaporation, the residue was dissolved in dichioromethane, washed with saturated solution of sodium bicarbonate, dried with magnesium sulfate and concentrated under vacuum to yield 2-(5-bromo-thiazol-4-yl)-5-methyl-1H-benzoimidazole (1.93 g, crude,quantitative yield for two steps) as a beige solid that was used into the next step without further purification. ?H NMR (CHLOROFORM-d) 3: 8.82 (s, 1H), 7.64 (d, J = 7.9 Hz, iH), 7.47 (s, 1H), 7.15 (d, J = 8.3 Hz, 1H), 2.50 (s, 3H); LCMS (El/Cl) m/z: 293.9, 295.9 [M + H]., 103878-58-6

The synthetic route of 103878-58-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BHAGIRATH, Niala; DOMINIQUE, Romyr; KENNEDY-SMITH, Joshua; LUCAS, Matthew C.; PADILLA, Fernando; WO2014/64134; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica