Category: 10574-69-3

Nagase, Hiroshi published the artcile< Fungicides. XXII. Reaction of dimethyl acetylenedicarboxylate with dithiocarbamates, thiolcarbamates, thiosemicarbazides, and thiosemicarbazones>, Safety of 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is acetylenedicarboxylate reaction; thiocarbamate reaction acetylenedicarboxylate; thiosemicarbazide reaction acetylenedicarboxylate; thiosemicarbazone reaction acetylenedicarboxylate; thiazolidone.

Dimethyl acetylenedicarboxylate reacted readily with dithiocarbamates, thiolcarbamates, thiosemicarbazides, and thiosemicarbazones to give 4-thiazolidones [I, R = H, alkyl, PhCH2, NH2; X = S (II), O NR1 (R1 = Me, Ph, substituted-methyleneamino)]. The exo double bond of 4-thiazolidones (II) was highly reactive to dithiocarbamates to give 2,2′-dithioxo-5,5′-bi-4-thiazolidones, which were autoxidized to 2,2′-dithioxo-Δ5,5′-bi-4-thiazolidones in the presence of catalytic amount of amines.

Chemical & Pharmaceutical Bulletin published new progress about 10574-69-3. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Safety of 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Devi, N. S.; Devi, Nirada published the artcile< Organocatalytic synthesis of N-substituted 5-arylidene rhodanines>, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is rhodanine aryl aldehyde proline catalyst diastereoselective aldol condensation; arylidenerhodanine preparation green chem.

A simple and efficient synthesis of N-substituted 5-arylidene rhodanines was developed via aldol condensation of N-substituted rhodanines with aromatic aldehydes using L-proline as the catalyst in water at room temperature The attractive features of this protocol were simple exptl. procedures, cleaner reactions, column free, high yield and avoids the use of toxic solvents.

Asian Journal of Chemistry published new progress about Aldol condensation catalysts, stereoselective. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Fahmy, H. T. Y.; Bekhit, A. A. published the artcile< Synthesis of some new bis-thiazoles as possible anticancer agents>, Reference of 10574-69-3, the main research area is rhodanine preparation antitumor agent.

Several new 5-(2,3-dihydrothiazol-2-ylidenyl)rhodanines I (R1 = Ph; R2 = Ph, 4-ClC6H4, 4-MeC6H4; R3 = H) and 5-(4-oxothiazolidinon-2-ylidenyl)rhodanine II were synthesized through the reaction of 5-thiocarbamoyl rhodanine III [R1 = Ph; R4 = C(S)NHPh] with phenacyl bromides or chloroacetic acid, resp. The synthesis of arylidenes IV (R5 = H, Cl, MeO) was also described. The 5-(4-amino-5-cyano-2,3-dihydrothiazol-2-ylidenyl)rhodanines I (R1 = Ph, CH2Ph; R2 = NH2; R3 = CN) were obtained through reaction of rhodanines III (R1 = Ph, CH2Ph; R4 = H) with a thiazolium salt. All the prepared compounds were screened for their anticancer activity using the in vitro anticancer screening program of the NCI. Three compounds showed promising anticancer activity against particular human cell lines used in the assay.

Pharmazie published new progress about Antitumor agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Reference of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Komanova, E.; Knoppova, V.; Koman, V.; Malinova, A. published the artcile< Gas chromatography of isothiocyanates and 3-substituted rhodanines>, SDS of cas: 10574-69-3, the main research area is retention time isothiocyanates; gas chromatog rhodanines.

Retention times in the gas chromatog. separation of 3-substituted alkyl- or arylrhodanines were 5.9 min higher than for the corresponding isothiocyanates, indicating a successful separation of a mixture of these compounds by gas-liquid chromatog. For example, the retention time observed for 4-ethoxyphenyl isothiocyanate was 18.03 min while that of 4-(ethoxyphenyl)-3-rhodanine (I) was 24.02 min. A plot of Hammett constants vs. retention times for 4-substituted isothiocyanates and 3-substituted rhodanines was not linear. Electron-releasing substituents shifted their retention times to lower values while electron-withdrawing substituents had the opposite effect.

Journal of Chromatography published new progress about Linear free energy relationship. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, SDS of cas: 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Demekhin, Oleg D.; Burov, Oleg N.; Kletskii, Mikhail E.; Lisovin, Anton V.; Kurbatov, Sergey V.; Bereznyak, Elena A.; Trishina, Alena V. published the artcile< New 13-vinyl derivatives of berberine: synthesis and characterization>, Safety of 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is electroneutral vinyl berberine preparation antibacterial SAR density functional theory.

The possibility of obtaining electroneutral substituted 13-vinylberberines I [R = H, CH2C(O)CH3; R1 = dicyanomethyl, 1,3-dimethoxy-1,3-dioxopropan-2-yl, 2,4,6-trioxo-1,3-diazinan-5-yl, etc.] was demonstrated exptl. and via quantum-chem. DFT/B3LYP calculations in the 6-31++G(d,p) basis set. The introduction of pharmacophoric fragments conjugated through vinyl moiety opened new possibilities for structural modification of berberine, enabling pronounced changes in tropicity toward supramol. biol. structures. The newly synthesized 13-vinylberberines I were stable in their reduced form due to significant intramol. electron d. transfer from berberine ring system to the vinyl moiety bearing electron-withdrawing groups. It was demonstrated that berberine derivatives I may exist not only in ion pair form consisting of organic cation and inorganic anion, but also as zwitterionic structures featuring significant intramol. charge transfer. The obtained 13-vinylberberines I exhibited biol. activity against the highly pathogenic Vibrio cholerae.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Safety of 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shahwar, Durre; Tahir, M. Nawaz; Raza, Muhammad Asam; Ahmad, Naeem; Aslam, Saherish published the artcile< 3-Benzyl-2-sulfanylidene-1,3-thiazolidin-4-one>, Safety of 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is mol structure benzyl sulfanylidene thiazolidinone; crystal structure benzyl sulfanylidene thiazolidinone.

In the title compound, C10H9NOS2, the five-membered heterocyclic ring and the benzyl moiety are oriented at a dihedral angle of 77.25(4)°. In the crystal, infinite polymeric C(6) chains extending along [001] are formed due to C-H…O H bonds. C-H…π interactions link the chains, building up a three-dimensional network. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Safety of 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

He, Xiao-Yang; Lu, Lu; Qiu, Jiayin; Zou, Peng; Yu, Fei; Jiang, Xing-Kai; Li, Lin; Jiang, Shibo; Liu, Shuwen; Xie, Lan published the artcile< Small molecule fusion inhibitors: Design, synthesis and biological evaluation of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives targeting HIV-1 gp41>, Reference of 10574-69-3, the main research area is benzyloxothioxothiazolidinylidenemethyl carboxyhydroxyphenyl dimethylpyrrole preparation antiaids AIDS HIV fusion inhibitor; 3-Substituted N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrrole derivatives; Anti-HIV agents; HIV-1 gp41; Small-molecule fusion inhibitors.

By a scaffold elongation strategy, a series of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles I [R = Ph, 4-BrC6H4, 4-MeOC6H4, etc.; X = (CH2)n; n = 0-2] and related derivatives with a linear multiarom.-ring skeleton were designed, synthesized, and evaluated in HIV-1 gp41 and cellular assays. the most active compounds I [R = 4-MeO2CC6H4; 4-tBuC6H4; 3-MeO2CC6H4; X = CH2] exhibited very promising inhibitory potency with IC50 values of 1.8-2.6 μM and EC50 values of 0.3-1.5 μM against gp41 6-HB formation and HIV-1 replication in MT-2 cells, resp. Addnl., they were almost equally effective against both T20-sensitive and resistant strains. The related SAR studies and mol. modeling results provided potential for further developing a new class of nonpeptide small mol. fusion inhibitors targeting the HIV-1 gp41.

Bioorganic & Medicinal Chemistry published new progress about AIDS (disease). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Reference of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Augustin, J.; Drobnica, L.; Kristian, P. published the artcile< Antimicrobial activity of dithiocarbamates and other sulfur containing compounds>, HPLC of Formula: 10574-69-3, the main research area is sulfur compound ionization equilibrium microbicide; thiocarbamate ionization equilibrium microbicide.

The rate of decomposition of monothiocabamates, dithiocarbamates and their esters, and 3-substituted rhodanines in acidic, neutral, and alk. solutions was calculated from spectrophotometric measurements in absorption maximum in the UV region. Reactions were pH-dependent; thus, ionization equilibrium is involved in compound stability in solution and in their microbicidal activity, i.e., isothiocyanate formation.

Abhandlungen der Akademie der Wissenschaften der DDR, Abteilung Mathematik, Naturwissenschaften, Technik published new progress about Decomposition. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, HPLC of Formula: 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pil’o, S. G.; Brovarets, V. S.; Romanenko, E. A.; Drach, B. S. published the artcile< Reaction of 3,3-dichloro-2-[(dichloroacetyl)amino]acrylonitrile with amines>, Electric Literature of 10574-69-3, the main research area is oxazolecarbonitrile derivative preparation hydrolysis condensation reaction; polychlorinated enamidonitrile heterocyclization amine.

Polychlorinated enamidonitrile Cl2C:C(CN)NHCOCHCl2 readily reacts with primary aromatic amines, dialkylamines, piperidine, and morpholine. The reaction is accompanied by complete elimination of chlorine atoms as chloride ions with formation of 4-cyanooxazoles having the corresponding amine residue in position 5 of the ring and a CH:N or diaminomethyl moiety in position 2. The structure of 5-arylamino(dialkylamino)-4-cyano-2-formyloxazoles was confirmed by their acid hydrolysis, as well as by condensation with phenylhydrazine, N-alkylrhodanines, and Et acetoacetate in the presence of urea.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Electric Literature of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sinenko, V. O.; Slivchuk, S. R.; Pil’o, S. G.; Raenko, G. F.; Brovarets, V. S. published the artcile< Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes>, Application of C10H9NOS2, the main research area is thiazole preparation; carbaldehyde thiazole acetoacetic ester urea Biginelli; phenylhydrazine isoniazid rhodanine thiazole carbaldehyde condensation.

Reactions of substituted 2-hydroxyalkyl-1,3-thiazole-5-carbaldehydes and 5-hydroxyalkyl-1,3-thiazole-2-carbaldehydes with phenylhydrazine, isoniazid, N-substituted rhodanines were performed as well as Biginelli reaction with acetoacetic ester and urea. As a result, new 1,3-thiazole derivatives were obtained. They are of interest as potential bioactive substances.

Russian Journal of General Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Application of C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica