Category: 10574-69-3

Liang, Xiao; Fu, Huansheng; Xiao, Peng; Fang, Hao; Hou, Xuben published the artcile< Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors>, Name: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is thioxothiazolidinone preparation docking lymphoid tyrosine phosphatase inhibitor autoimmunity; imidazolidinedione preparation diastereoselective docking lymphoid tyrosine phosphatase inhibitor autoimmunity; Autoimmune diseases; Inhibitor; Lymphoid-specific tyrosine phosphatase.

Synthesized imidazolidine-2,4-dione derivatives I [R = carboxymethyl, Ph, benzyl, (4-carboxyphenyl)methyl, (4-phenylphenyl)methyl] and 2-thioxothiazolidin-4-one derivatives II (R1 = Bu, cyclohexyl, 2-chlorophenyl, thiazol-2-yl, etc.; R2 = carboxy, 4-carboxyphenyl, 2-carboxyeth-1-en-1-yl, etc.) as new LYP inhibitors were designed. Among them, the cinnamic acids-based inhibitors II [R1 = 2-methoxyphenyl, R2 = ((4-((1E)-2-carboxyeth-1-en-1-yl)phenyl)methyl)oxidanyl; R1 = 4-chlorophenyl, R2 = ((4-((1E)-2-carboxyeth-1-en-1-yl)phenyl)methyl)oxidanyl (III)] displayed good LYP inhibitory activities (IC50 = 2.85-6.95μM). Especially, the most potent inhibitor III was identified as competitive inhibitor (Ki = 1.09μM) and bind LYP reversibly. Meanwhile, III exhibited better selectivity over other phosphatases than known LYP inhibitor A15. Furthermore, compound III could regulate TCR associated signaling pathway in Jurkat T cell.

Bioorganic Chemistry published new progress about Aralkyl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Name: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Roosta, Atefeh; Alizadeh, Abdolali; Rezaiyehraad, Reze; Khanpour, Mojtaba published the artcile< Efficient and Chemoselective Procedure for Conversion of Rhodanine Derivatives into 1,3-Thiazolidine-2,4-diones via 1,3-Dipolar Cycloaddition Reaction and Rearrangement Sequences>, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is thiazolidinedione preparation chemoselective; alkalinity arylidene rhodanine preparation cycloaddition rearrangement.

A chemoselective 1,3-dipolar cycloaddition reaction between 5-alkylidene- or 5-arylidene rhodanine derivatives I (R1 = n-Pr, n-Bu, allyl, Bn; R2 = Ph, COOMe, 4-chloropheny, 4-methylpheny, 4-bromopheny) and nitrile oxide generated in situ from dibromoformaldoxime to construct 1,3-thiazolidine-2,4-diones II scaffold under mild conditions was reported. This strategy exhibits a distinguished manner to afford thiazolidine derivatives II in a simple, rapid and practical route. The results proved that the reaction proceeds through an unpredictable rearrangement and no spirocyclic product is generated. The structures of the target mols. were confirmed by IR, 1H NMR, 13C NMR, mass spectra and unambiguously X-ray crystal structure anal.

ChemistrySelect published new progress about 1,3-Dipolar cycloaddition reaction (chemoselective). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Knoppova, V.; Antos, K.; Drobnica, L.; Kristian, P. published the artcile< Isothiocyanates. XXX. Synthesis, ultraviolet, and infrared spectra of 3-substituted rhodanines>, Application of C10H9NOS2, the main research area is rhodanine derivative IR UV.

Twenty-five rhodanine derivatives I (R = Me, Bu, p-BrC6H4, Ph, p-MeC6H4, 1-naphthyl, etc.) were prepared by treating the appropriate RNHCS2- or RNCS with ClCH2CO2H and HSCH2CO2H, resp. The products were characterized by uv absorptions at ∼250 and ∼290 nm, and an ir signal at 1725-1728 cm-1. The effect of substituents on the spectra was discussed.

Chemicke Zvesti published new progress about IR spectra. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Application of C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

L’abbe, Gerrit; Yu, Chih-Chou published the artcile< Trapping of thiaziridinimines with thiocarbonyl compounds>, Formula: C10H9NOS2, the main research area is thiaziridinimine thiocarbonyl trap; dithiazolidine spirothiazolidine; thiazolidine spirodithiazolidine; thiatriazoline thermolysis; dithiazolidinimine.

Thermolysis of 4-benzyl-5-tosylimino-1,2,3,4-thiatriazoline (I; Ts = 4-MeC6H4SO2) at 60-70° in the presence of representative C=S unsaturated compounds furnished 1,2,4-dithiazolidin-5-imines in moderate yields. An intermediate unstable thiaziridinimine which is trapped by the C=S compound in a regiospecific manner is postulated. Among the thiocarbonyl compounds used are p,p’-dimethoxythiobenzophenone, xanthates and 3-benzylrhodanine, the latter giving a spiro adduct II.

Journal of Heterocyclic Chemistry published new progress about 10574-69-3. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Formula: C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tissaoui, Khalil; Raouafi, Noureddine; Boujlel, Khaled published the artcile< Electrogenerated base-promoted synthesis of N-benzylic rhodanine and carbamodithioate derivatives>, Formula: C10H9NOS2, the main research area is rhodanine carbamodithioate benzylic electrosynthesis.

Electrogenerated magnesium-associated cyanomethyl anions/bases obtained from the electrochem. reduction of acetonitrile and the oxidation of a sacrificial magnesium rod were successfully used to promote the addition of carbon disulfide to primary benzylic amines. Alkylation with Et 3-bromopropionate or with Et 2-bromoacetate yields the corresponding carbamodithioates R1NHC(S)SCH2CH2CO2Et (R1 = PhCH2, 2-ClC6H4CH2, 2-pyridylmethyl, etc.) or cyclic rhodanines I (R2 = PhCH2, 2-ClC6H4CH2, 3-furylmethyl, etc.), resp. The effect of the amount of electrogenerated base on the yield of reaction was also evaluated.

Journal of Sulfur Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Formula: C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kharidia, S. P.; Trivedi, J. J. published the artcile< Synthesis of 3-(substituted benzyl)-5-alkylrhodanines>, Related Products of 10574-69-3, the main research area is .

Preparation of benzylamines and benzylammonium dithiocarbamates (not isolated) and their condensation with α-halo fatty acids were carried out according to Raval and T. (CA 57, 12465h) to give the tabulated I (m.ps. shown). I showed no antifungal, antibacterial, or antiprotozoal activity.

Journal of the Indian Chemical Society published new progress about 10574-69-3. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Related Products of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Martinez, Ana; Alonso, Mercedes; Castro, Ana; Dorronsoro, Isabel; Gelpi, J. Luis; Luque, F. Javier; Perez, Concepcion; Moreno, Francisco J. published the artcile< SAR and 3D-QSAR Studies on Thiadiazolidinone Derivatives: Exploration of Structural Requirements for Glycogen Synthase Kinase 3 Inhibitors>, Safety of 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is thiadiazolidinone derivative preparation QSAR glycogen synthase kinase 3 inhibitor.

The 2,4-disubstituted thiadiazolidinones (TDZD) are described as the first ATP-noncompetitive GSK-3 inhibitors. Following an SAR study about TDZD, different structural modifications in the heterocyclic ring aimed to test the influence of each heteroatom on the biol. study are here reported here. Various compounds such as hydantoins, dithiazolidindiones, rhodanines, maleimides, and triazoles were synthesized and screened as GSK-3 inhibitors. After an extensive SAR study among these different heterocyclic families, TDZDs have been revealed as a privileged scaffold for the selective inhibition of GSK-3. A Co-MFA anal. was also performed highlighting the mol. electrostatic field interaction in the interaction of TDZDs with GSK-3. Moreover, first mapping studies indicate two binding modes which in turn might imply relevant differences in the mechanism that underly the inhibitory activity of TDZDs.

Journal of Medicinal Chemistry published new progress about Conformation. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Safety of 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Drobnica, L.; Knoppova, V.; Komanova, E. published the artcile< Isothiocyanates. XXXII. Microsynthesis of 3-substituted rhodanines>, Related Products of 10574-69-3, the main research area is rhodanine isothiocyanate thioglycolate.

Eleven 3-substituted rhodanines (I, R = Me, allyl, Ph, p-MeOC6H4, PhCH2, etc.) were prepared by addition of RNCS to HSCH2CO2R1(R1 = H, Et) and acid cyclization of the resultant thiocarbamoylmercaptoacetates RNHCS2CH2CO2R1. I were purified by thinlayer chromatog. Kinetic and uv data were given.

Chemicke Zvesti published new progress about 10574-69-3. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Related Products of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Devi, N. S.; Devi, Nirada published the artcile< Catalyst-free aldol reaction of N-substituted rhodanines on aqueous media>, Quality Control of 10574-69-3, the main research area is rhodanine aryl aldehyde aldol reaction green chem water.

Herein, aldol reaction of N-substituted rhodanines and aromatic aldehydes on water is described. The reaction was performed at room temperature affording the products I (R1 = Me, Ph, PhCH2, 4-MeOC6H4CH2; R2 = 4-ClC6H4, 2-O2NC6H4, 3-O2NC6H4, 4-O2NC6H4, 4-NCC6H4) in good to high yields. This synthetic protocol uses simple exptl. procedures, is catalyst-free, and avoids the use of highly toxic solvents.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Aldol addition. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Quality Control of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shvets, A. A.; Nelyubina, Yu. V.; Lyssenko, K. A.; Kurbatov, S. V. published the artcile< Synthesis of bis-spiro-fused thiapyrrolizidinooxindoles by 1,3-dipolar cycloaddition>, Product Details of C10H9NOS2, the main research area is thiaproline azomethine ylide arylidenerhodanine regioselective diastereoselective dipolar cycloaddition; spiro thiapyrrolizidine oxindole regioselective diastereoselective preparation.

The 1,3-dipolar cycloaddition of an unstabilized azomethine ylide, generated in situ from isatin and thiaproline, to arylidene derivatives of rhodanine affords bis-spiro-fused thiapyrrolizidinooxindoles. The 1,3-dipolar addition reactions under consideration are fully regio- and diastereoselective.

Russian Chemical Bulletin published new progress about 1,3-Dipolar cycloaddition reaction (stereoselective). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Product Details of C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica