Category: 10574-69-3

Mandal, Subhankar P.; Mithuna; Garg, Aakriti; Sahetya, Sanjana S.; Nagendra, S. R.; Sripad, H. S.; Manjunath, Mendon Manisha; Sitaram; Soni, Mukesh; Baig, R. Nasir; Kumar, S. Vasanth; Kumar, B. R. Prashantha published the artcile< Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study>, COA of Formula: C10H9NOS2, the main research area is rhodanine anticancer agent breast cancer cell QSAR.

Three different series of some novel N-substituted rhodanines were designed for anticancer activity and prepared from the corresponding dithiocarbamates. The synthesized compounds were analyzed by IR, NMR and MASS to confirm their structures. All the titled compounds were found to be of Z configuration based on NMR spectral anal. All the synthesized rhodanines were screened for in vitro anticancer activity against MCF-7 breast cancer cells at the concentration of 10 μg. The compounds showed moderate to significant cytotoxicity. Amongst them, interestingly, compounds 10, 22 and 33 with cinnamoyl substitution at the 5th position of the thiazolidine ring system showed significant activity. Further, we subjected all these compounds to a CoMSIA study to study their 3D quant. structure activity relationships (3D QSAR). The illustration about the design of novel rhodanines, synthesis, anal., activity against MCF-7 cells and SAR via CoMSIA study are reported here.

RSC Advances published new progress about Antitumor agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, COA of Formula: C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shvets, A. A.; Mikhailovskii, A. G.; Zimakov, D. V.; Kurbatov, S. V.; Surikova, O. V. published the artcile< New ylidene derivatives of pyrrolo[2,1-α]isoquinoline-2,3-dione in the synthesis of dispiropyrrolidines>, COA of Formula: C10H9NOS2, the main research area is ylidene pyrroloisoquinolinone sarcosine paraformaldehyde three component spirocyclization; dispiro pyrrolidine preparation; spiro thiazolidine pyrrolidine pyrroloisoquinolinone preparation.

Condensation of 5,5-dimethylpyrrolo[2,1-α]isoquinoline-2,3-dione with N-benzylrhodanine afforded the corresponding 2-thiazolidin-5-ylidene derivative, which on subsequent treatment with sarcosine and (CH2O)n was converted into the dispiro compound I.

Russian Journal of Organic Chemistry published new progress about Spirocyclization. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, COA of Formula: C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Singh, Sarangthem Joychandra; Devi, Nepram Sushuma published the artcile< Diacetoxyiodobenzene mediated oxidative dethionation of N-substituted 5-arylmethylidene rhodanines: an efficient synthesis of N-substituted 5-arylmethylidene thiazolidine-2,4-diones>, HPLC of Formula: 10574-69-3, the main research area is arylmethylidene thiazolidine dione preparation; rhodanine arylmethylidene oxidative dethionation.

A simple and efficient synthesis of N-substituted-5-arylmethylidene thiazolidine-2,4-diones I (R1 = Ph, 2-fluorophenyl, 4-methoxyphenyl, 2-furyl, etc.; R2 = CH3, C6H5CH2, CH2=CHCH2; X = S) has been developed via oxidative dethionation of N-substituted-5-arylmethylidene rhodanines I (R1 = Ph, 2-fluorophenyl, 4-methoxyphenyl, 2-furyl, etc.; R2 = CH3, C6H5CH2, CH2=CHCH2; X = O) using diacetoxyiodobenzene (DIB) in ethanol at room temperature This protocol is simple, mild and column free, and obviates the need of acids and bases, and offers a broad substrate scope.

ARKIVOC (Gainesville, FL, United States) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, HPLC of Formula: 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Moghimi, S.; Heravi, M. M.; Oskooie, H. A.; Beheshtiha, Y. S. published the artcile< A novel un-catalyzed and solvent-free method for the synthesis of 2-thioxothiazolidin-4-ones>, Category: thiazole, the main research area is rhodanine preparation catalyst solvent free; primary amine carbon disulfide chloroacetyl chloride multicomponent re??action.

An easy and highly efficient one-pot, three-component synthesis of rhodanines was reported. The reaction of primary amines, carbon disulfide and chloroacetyl chloride proceeded in the absence of solvent and catalyst affording 2-thioxothiazolidin-4-ones in good to excellent yields.

Scientia Iranica, Transaction C: Chemistry, Chemical Engineering published new progress about Primary amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tejchman, W.; Korohoda, M. J. published the artcile< Introduction of selenium to heterocyclic compounds. Part VII. Synthesis of 3-alkyl-5-benzylidene- and 3-alkyl-5-cinnamylidene-2-selenorhodanines>, SDS of cas: 10574-69-3, the main research area is selenylation rhodanine benzylidene cinnamylidene.

Five new 3-alkyl-5-benzylidene- and five new 3-alkyl-5-cinnamylidene-2-selenorhodanines I (R = Ph, CH:CHPh; R1 = Et, Pr, Bu, n-pentyl, PhCH2) were obtained by methylation of the corresponding rhodanines and subsequent treatment with H2Se. The stability of 2-thiazolinium salts with SCH3 or RNCH3 group formed during methylation is determined by substituents at C-5 and N-3 atoms.

Polish Journal of Chemistry published new progress about Heterocyclic compounds, selenium Role: SPN (Synthetic Preparation), PREP (Preparation). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, SDS of cas: 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Matsui, Masaki; Asamura, Yoshinori; Kubota, Yasuhiro; Funabiki, Kazumasa; Jin, Jiye; Yoshida, Tsukasa; Miura, Hidetoshi published the artcile< Highly efficient substituted triple rhodanine indoline dyes in zinc oxide dye-sensitized solar cell>, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is rhodanine indoline dye zinc oxide dye sensitized solar cell.

Substituted triple rhodanine indoline dyes showed higher performance than known triple rhodanine derivative (D150). A few triple rhodanine indoline derivatives showed comparable conversion efficiency to D149.

Tetrahedron published new progress about Dye-sensitized solar cells (triple rhodanine indoline dyes-based). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vyzhdak, R. N.; Danielova, A. A.; Kiselev, V. V.; Drach, B. S. published the artcile< Derivatives of 5-(Dimethylamino)-4-tosyl-1,3-oxazole-2-carbaldehyde and Its Analogs>, Category: thiazole, the main research area is oxazolecarbaldehyde amino tosyl preparation condensation.

Treatment of N-(2,2,2-trichloro-1-tosylethyl)dichloroacetamide with excess Me2NH, piperidine, or morpholine gave substituted aminals of the oxazole series, whose facile acid hydrolysis provided 5-(dimethylamino)-4-tosyl-1,3-oxazole-2-carbaldehyde and its analogs having the piperidino and morpholino group in the 5-position of the oxazole ring. The resulting aldehydes and their aminals were condensed with PhN2H3, thiosemicarbazide, N-alkylrhodanines, and 1,3-dimethylbarbituric acid to obtain 2,5-disubstituted 4-tosyl-1,3-oxazoles.

Russian Journal of General Chemistry published new progress about Cyclization. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Li, Xiaokai; Srinivasan, Sharan R.; Connarn, Jamie; Ahmad, Atta; Young, Zapporah T.; Kabza, Adam M.; Zuiderweg, Erik. R. P.; Sun, Duxin; Gestwicki, Jason E. published the artcile< Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents>, Product Details of C10H9NOS2, the main research area is benthiazolyl cationic rhodacyanine preparation allosteric Hsp70 inhibitor antitumor; Hsp90; breast cancer; mortalin; p53; proteostasis.

The rhodacyanine, MKT-077, has antiproliferative activity against cancer cell lines through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of mol. chaperones. However, MKT-077 is rapidly metabolized, which limits its use as either a chem. probe or potential therapeutic. The synthesis and characterization of MKT-077 analogs designed for greater stability is reported. The most potent mols., such as I (JG-98), were at least 3-fold more active than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 values of 0.4 ± 0.03 and 0.7 ± 0.2 μM, resp.). The analogs modestly destabilized the chaperone clients, Akt1 and Raf1, and induced apoptosis in these cells. Further, the microsomal half-life of JG-98 was improved at least 7-fold (t1/2 = 37 min) compared to MKT-077 (t1/2 < 5 min). Finally, NMR titration experiments suggested that these analogs bind an allosteric site that is known to accommodate MKT-077. These studies advance MKT-077 analogs as chem. probes for studying Hsp70s roles in cancer. ACS Medicinal Chemistry Letters published new progress about Antiproliferative agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Product Details of C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pulici, Maurizio; Quartieri, Francesca published the artcile< Traceless solid-phase synthesis of 2-amino-5-alkylidene-thiazol-4-ones>, Name: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is polymer supported rhodanine arylaldehyde Knoevenagel condensation amine resin cleavage; aminoalkyldiene thiazolone stereoselective preparation.

2-Amino-5-alkylidene-thiazol-4-ones, e.g., I, bearing two diversity points were prepared by a solid-phase strategy exploiting rhodanine as the starting material. Rhodanine was first loaded on bromo-Wang resin, subjected to Knoevenagel condensation with aldehydes, and cleaved off the resin in a traceless manner by means of an amine.

Tetrahedron Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Name: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nagase, Hiroshi published the artcile< Fungicides. XXVI. Addition of 2,3-dimethylbutadiene to 5-methoxycarbonylmethylidene-2-thioxo-4-thiazolidones and 5-aroylmethylidene-2-thioxo-4-thiazolidones>, Name: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is thiazolidonespirocyclohexene thioxo; spirothiazolecyclohexenone thioxo; thiazolidone cycloaddition butadiene.

The thiazolidonespirocyclohexenes I (R = MeO, R1 = Me, PhCH2; R = Ph, p-ClC6H4, R1 = PhCH2) were prepared by treating the thiazolone II with CH2:CMeCMe:CH2.

Chemical & Pharmaceutical Bulletin published new progress about Cycloaddition reaction. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Name: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica